Induction of oocyte-like cells from mouse embryonic stem cells by co-culture with ovarian granulosa cells [0.03%]
卵泡颗粒细胞共培养诱导小鼠胚胎干细胞向类似卵母细胞的细胞分化
Tingting Qing,Yan Shi,Han Qin et al.
Tingting Qing et al.
In vitro derivation of oocytes from embryonic stem (ES) cells has the potential to be an important tool for studying oogenesis as well as advancing the field of therapeutic cloning by providing an alternative source of oocytes. Here, we dem...
Gonadal expression of Sf1 and aromatase during sex determination in the red-eared slider turtle (Trachemys scripta), a reptile with temperature-dependent sex determination [0.03%]
红耳滑龟（一种性别由温度决定的爬行动物）在性别决定期间性腺Sf1和芳香化酶的表达
Mary Ramsey,Christina Shoemaker,David Crews
Mary Ramsey
Many egg-laying reptiles have temperature-dependent sex determination (TSD), where the offspring sex is determined by incubation temperature during a temperature-sensitive period (TSP) in the middle third of development. The underlying mech...
Terminal differentiation of nail matrix keratinocytes involves up-regulation of DNase1L2 but is independent of caspase-14 expression [0.03%]
指甲母质角质形成细胞终末分化的机制研究及DNase1L2的上调与caspase-14无关
Karin Jäger,Heinz Fischer,Erwin Tschachler et al.
Karin Jäger et al.
Terminal differentiation of keratinocytes in the epidermis and in epidermal appendages results in specialized forms of cell death. Keratinocytes of the nail matrix differentiate into nail corneocytes, the building blocks of the nail plate. ...
Potential treatment of liver-related disorders with in vitro expanded human liver precursors [0.03%]
体外扩增的人肝前体细胞在治疗肝脏相关性疾病中的潜在作用
Ying Yang,Junke Zheng,Xiaofei Zhou et al.
Ying Yang et al.
Inherited deficiencies in critical components of metabolic pathways are the primary cause of many liver and lysosomal disorders, most of which are incurable. Stem cell transplantation may offer a new type of treatment for these diseases. We...
Dkk3 is required for TGF-beta signaling during Xenopus mesoderm induction [0.03%]
Dkk3在斑马鱼中胚层诱导过程中参与TGF-β信号转导路径
Sonia Pinho,Christof Niehrs
Sonia Pinho
The Dickkopf (Dkk) family is composed of four main members (Dkk1-4), which typically regulate Wnt/beta-catenin signaling. An exception is Dkk3, which does not affect Wnt/beta-catenin signaling and whose function is poorly characterized. Her...
Urothelial sonic hedgehog signaling plays an important role in bladder smooth muscle formation [0.03%]
尿上皮细胞 sonic hedgehog 信号传导在膀胱平滑肌形成中起重要作用
Yoshiyuki Shiroyanagi,Benchun Liu,Mei Cao et al.
Yoshiyuki Shiroyanagi et al.
During bladder development, primitive mesenchyme differentiates into smooth muscle (SM) under the influence of urothelium. The gene(s) responsible for this process have not been elucidated. We propose that the Sonic hedgehog (Shh) signaling...
Disruption of the dynamic sub-cellular localization of the Xenopus tumorhead protein causes embryonic lethality at the early gastrula transition [0.03%]
两栖类肿瘤头部蛋白动态亚细胞定位的中断会引起原肠胚形成早期胚胎致死性异常
Edwin E Traverso,Min-Soon Cho,Chuan-Fen Wu et al.
Edwin E Traverso et al.
The Xenopus laevis tumorhead (TH) protein, a positive regulator of cell proliferation during embryogenesis, shuttles from the cell periphery into the nucleus during embryogenesis. In these studies, we performed a detailed analysis of TH's s...
NOTCH1, 2, and 3 receptors enhance osteoblastogenesis of mesenchymal C3H10T1/2 cells and inhibit this process in preosteoblastic MC3T3-E1 cells [0.03%]
notch1、notch2和notch3受体促进成脂细胞前体c3h10t1/2细胞的成骨分化并抑制成骨前体mc3t3-e1细胞的成骨分化
Osteoblastogenesis is governed by complex interplays among signaling pathways, which modulate the expression of specific markers at each differentiation stage. This process enables osteoblast precursor cells to adopt the morphological and b...
Human wingless-type MMTV integration site family member 10A (WNT10A) is a secreted glycoprotein that is involved in signaling pathways essential to ectodermal organogenesis and tissue regeneration. WNT10A was first linked to human disorders...