Guillaume J Trusz
Guillaume J Trusz
Fibroblast growth factor 21 (FGF21) belongs to the FGF19 subfamily and acts systemically, playing a key role in inter-organ crosstalk. Ranging from metabolism, reproduction, and immunity, FGF21 is a pleiotropic hormone which contributes to ...
In vivo movement of retinoblastoma-related protein (RBR) towards cytoplasm during mitosis in Arabidopsisthaliana [0.03%]
拟南芥细胞有丝分裂过程中视网膜母细胞瘤相关蛋白(RBR)向细胞质运动的活体观察
Sergio Miguel-Hernández,Estephania Zluhan-Martínez,Adriana Garay-Arroyo et al.
Sergio Miguel-Hernández et al.
Retinoblastoma protein is central in signaling networks of fundamental cell decisions such as proliferation and differentiation in all metazoans and cancer development. Immunostaining and biochemical evidence demonstrated that during interp...
Generation of a Wt1 conditional deletion, nuclear red fluorescent protein reporter allele in the mouse [0.03%]
生成携带WT1 条件性敲除和核红荧光报告标记的小鼠品系
Jace A Aloway,E Cristy Ruteshouser,Vicki Huff et al.
Jace A Aloway et al.
A Wt1 conditional deletion, nuclear red fluorescent protein (RFP) reporter allele was generated in the mouse by gene targeting in embryonic stem cells. Upon Cre-mediated recombination, a deletion allele is generated that expresses RFP in a ...
Lens placode modulates extracellular matrix formation during early eye development [0.03%]
晶状体原始芽调节早期眼发育中的细胞外基质形成
Cecília G De Magalhães,Ales Cvekl,Ruy G Jaeger et al.
Cecília G De Magalhães et al.
The role extracellular matrix (ECM) in multiple events of morphogenesis has been well described, little is known about its specific role in early eye development. One of the first morphogenic events in lens development is placodal thickenin...
Characterization of the zebrafish gabra1sa43718/sa43718 germline loss of function allele confirms a function for Gabra1 in motility and nervous system development [0.03%]
斑马鱼gabra1sa43718/sa43718基因组功能丧失型等位基因的鉴定证实了Gabra1在运动和神经系统发育中的作用
Nayeli G Reyes-Nava,David Paz,Briana E Pinales et al.
Nayeli G Reyes-Nava et al.
Mutation of the GABRA1 gene is associated with neurodevelopmental defects and epilepsy. GABRA1 encodes for the α1 subunit of the γ-aminobutyric acid type A receptor (GABAAR), which regulates the fast inhibitory impulses of the nervous sys...
Exploring the impact of osteoprotegerin on osteoclast and precursor fusion: Mechanisms and modulation by ATP [0.03%]
探讨骨保护素对破骨细胞和前体融合的影响：机制及ATP的调节作用
Yunwen Peng,Hongyan Zhao,Sinan Hu et al.
Yunwen Peng et al.
Osteoclast (OC) differentiation, vital for bone resorption, depends on osteoclast and precursor fusion. Osteoprotegerin (OPG) inhibits osteoclast differentiation. OPG's influence on fusion and mechanisms is unclear. Osteoclasts and precurso...
The ciliary protein C2cd3 is required for mandibular musculoskeletal tissue patterning [0.03%]
睫状蛋白C2cd3是下颌肌肉骨骼组织模式形成的必要条件
Evan C Brooks,Simon J Y Han,Christian Louis Bonatto Paese et al.
Evan C Brooks et al.
The mandible is composed of several musculoskeletal tissues including bone, cartilage, and tendon that require precise patterning to ensure structural and functional integrity. Interestingly, most of these tissues are derived from one multi...
Pax6 isoforms shape eye development: Insights from developmental stages and organoid models [0.03%]
Pax6不同剪接变异体通过调控视杯起始和视网膜发育塑造眼睛形态：从发育阶段到类器官模型的启示
Shih-Shun Hung,Po-Sung Tsai,Ching-Wen Po et al.
Shih-Shun Hung et al.
Pax6 is a critical transcription factor involved in the development of the central nervous system. However, in humans, mutations in Pax6 predominantly result in iris deficiency rather than neurological phenotypes. This may be attributed to ...
Fibroblast Growth Factor 6 [0.03%]
成纤维细胞生长因子6
Jennelle Smith,Loydie A Jerome-Majewska
Jennelle Smith
Fibroblast Growth Factor 6 (FGF6), also referred to as HST2 or HBGF6, is a member of the Fibroblast Growth Factor (FGF), the Heparin Binding Growth Factor (HBGF) and the Heparin Binding Secretory Transforming Gene (HST) families. The genomi...
Cell cycle perturbation uncouples mitotic progression and invasive behavior in a post-mitotic cell [0.03%]
细胞周期扰动使有丝分裂进程与后有丝分裂细胞的侵袭行为脱钩
Michael A Q Martinez,Chris Z Zhao,Frances E Q Moore et al.
Michael A Q Martinez et al.
The acquisition of the post-mitotic state is crucial for the execution of many terminally differentiated cell behaviors during organismal development. However, the mechanisms that maintain the post-mitotic state in this context remain poorl...