A primer on the pleiotropic endocrine fibroblast growth factor FGF19/FGF15 [0.03%]
FGF19/FGF15 pleiotropic内分泌纤维细胞生长因子的作用机制及生理功能研究进展
Agathe Bouju,Roel Nusse,Peng V Wu
Agathe Bouju
Fibroblast Growth Factor 19 (FGF19) is a member of the Fibroblast Growth Factor (FGF) family, known for its role in various cellular processes including embryonic development and metabolic regulation. FGF19 functions as an endocrine factor,...
The primary cilia: Orchestrating cranial neural crest cell development [0.03%]
原基纤毛：调控颅神经 crest 细胞发育
Hiroyuki Yamaguchi,Matthew D Meyer,William B Barrell et al.
Hiroyuki Yamaguchi et al.
Primary cilia (hereafter "cilia") are microtubule-based antenna-like organelles projecting from the surface of vertebrate cells. Cilia can serve as cellular antennae controlling cell growth and differentiation. Absent or dysfunctional cilia...
Monoallelic loss of RB1 enhances osteogenic differentiation and delays DNA repair without inducing tumorigenicity [0.03%]
RB1单等位基因丢失增强成骨分化并延迟DNA修复而不会诱导肿瘤发生
Ambily Vincent,Subramanian Krishnakumar,Sowmya Parameswaran
Ambily Vincent
The Retinoblastoma (RB1) gene plays a pivotal role in osteogenic differentiation. Our previous study, employing temporal gene expression analysis using quantitative reverse transcriptase polymerase chain reaction (qRT-PCR), revealed the der...
Lucia J Rivas,Rosa A Uribe
Lucia J Rivas
Fibroblast Growth Factor (FGF) 13, also referred to as FGF homologous factor (FHF) 2, is a member of the FGF11 subfamily that is characterized as having sequence similarities to classical FGF receptor (FGFR)-binding FGFs, but functionally d...
Zane Oberholzer,Chiron Loubser,Natalya V Nikitina
Zane Oberholzer
The Fibroblast growth factor (FGFs) family consists of at least 22 members that exert their function by binding and activating fibroblast growth factor receptors (FGFRs). The Fgf8/FgfD subfamily member, Fgf17, is located on human chromosome...
Jennelle Smith,Loydie A Jerome-Majewska
Jennelle Smith
Fibroblast Growth Factor 6 (FGF6), also referred to as HST2 or HBGF6, is a member of the Fibroblast Growth Factor (FGF), the Heparin Binding Growth Factor (HBGF) and the Heparin Binding Secretory Transforming Gene (HST) families. The genomi...
Jennifer L Fish
Jennifer L Fish
RUNX2 regulation in osteoblast differentiation: A possible therapeutic function of the lncRNA and miRNA-mediated network [0.03%]
RUNX2在成骨细胞分化中的调控：长非编码RNA和微小RNA网络的可能治疗功能研究
Pakkath Narayanan Arya,Iyyappan Saranya,Nagarajan Selvamurugan
Pakkath Narayanan Arya
Osteogenic differentiation is a crucial process in the formation of the skeleton and the remodeling of bones. It relies on a complex system of signaling pathways and transcription factors, including Runt-related transcription factor 2 (RUNX...
Sahar B Jamal,Dorit Hockman
Sahar B Jamal
Fibroblast Growth Factor 1 (Fgf1), also known as acidic FGF (aFGF), is involved in the regulation of various biological processes, ranging from development to disease pathogenesis. It is a single chain polypeptide and is highly expressed in...
Yangxi Zheng,Wei-Hsin Liu,Boxuan Yang et al.
Yangxi Zheng et al.
Fibroblast growth factor 7 (FGF7), also known as keratinocyte growth factor (KGF), is an important member of the FGF family that is mainly expressed by cells of mesenchymal origin while affecting specifically epithelial cells. Thus, FGF7 is...