The mechanism of EGF in promoting skeletal muscle post-injury regeneration [0.03%]
EGF促进骨骼肌损伤后再生的机制研究
Huaixin Teng,Yongze Liu,Ruotong Hao et al.
Huaixin Teng et al.
Epidermal Growth Factor (EGF) is a multifunctional cytokine that plays an important role in the growth and development of skeletal muscle. In this study, a mouse skeletal muscle post-injury regeneration model and the C2C12 myoblasts cell li...
Chondrocalcin: Insights into its regulation and multi-function in cartilage and bone [0.03%]
软骨钙蛋白：对其在软骨和骨骼中调节与多功能性的见解
Wensha Zhu,Zilong Zhao,Weigang Yuwen et al.
Wensha Zhu et al.
Type Ⅱ collagen (COLⅡ) is the primary constituent of the cartilage matrix, specifically present in vitreous bodies, cartilage, bone, and other skeletal elements. Therefore, the normal expression of COLⅡ is crucial for the normal developm...
NSAID-mediated cyclooxygenase inhibition disrupts ectodermal derivative formation in axolotl embryos [0.03%]
NSAID介导的环氧化酶抑制干扰了火蜥蜴胚胎外胚层衍生形成的形成
Emma J Marshall,Raneesh Ramarapu,Tess A Leathers et al.
Emma J Marshall et al.
Embryonic exposures to non-steroidal anti-inflammatory drugs (NSAIDs) have been linked to preterm birth, neural tube closure defects, abnormal enteric innervation, and craniofacial malformations, potentially due to disrupted neural tube or ...
Fibroblast growth factor 22 [0.03%]
纤维生长因子22
Rise Furuta,Ayumi Miyake
Rise Furuta
Fibroblast growth factor 22 (FGF22) is a member of the FGF7 subfamily that functions as a paracrine factor and was identified in the human placenta in 2001. The FGF22 gene is located on human chromosome 19p13.3, mouse chromosome 10, and zeb...
Immune Cell-NSPC interactions: Friend or foe in CNS injury and repair? [0.03%]
免疫细胞-NSPC相互作用：在中枢神经系统损伤和修复中是朋友还是敌人？
Chih-Wei Zeng
Chih-Wei Zeng
Neural stem/progenitor cells (NSPCs) play a crucial role in central nervous system (CNS) development, regeneration, and repair. However, their functionality and therapeutic potential are intricately modulated by interactions with immune cel...
FGFR3 signaling is essential for gastric cancer cell triggering the transition of BM-MSCs into tumor-associated MSCs [0.03%]
FGFR3信号对胃癌细胞触发BM-MSCs向肿瘤相关MSCs转换是必不可少的
Xiang Wang,Xiaoli Cao,Baocheng Zhou et al.
Xiang Wang et al.
Bone marrow-derived mesenchymal stem cells (BM-MSCs) tend to migrate towards tumor sites and interact with tumor cells, thus incorporating into tumor microenvironment by transition into various stromal cells, particularly tumor-associated M...
Targeting the reorganization of F-actin for cell-based implantation cartilage repair therapies [0.03%]
针对细胞基植入软骨修复疗法中F肌动蛋白的重新构架过程进行靶向处理
Alissa T Rzepski,Mandy M Schofield,Stephanie Richardson-Solorzano et al.
Alissa T Rzepski et al.
Articular cartilage is an avascular tissue that allows for frictionless mobility of joints. Unfortunately, cartilage is incapable of self-repair and any damage leads to degradation in osteoarthritis (OA). Autologous chondrocyte implantation...
Joshua A Moore,Loydie A Jerome-Majewska
Joshua A Moore
Splicing factors required for mRNA maturation have emerged as important contributors to neural crest development in the craniofacial region. Less is known of the role of these proteins in vagal neural crest cells that contribute to the outf...
Regulation of trophectoderm morphogenesis by small GTPase RHOA through HIPPO signaling-dependent and -independent mechanisms in mouse preimplantation development [0.03%]
小G蛋白RHOA通过Hippo信号依赖和非依赖机制调节小鼠早期胚胎滋养层发生发育
Yusuke Marikawa,Vernadeth B Alarcon
Yusuke Marikawa
The trophectoderm (TE) is the first tissue to differentiate during the preimplantation development of the mammalian embryo. It forms the outer layer of the blastocyst and is responsible for generating the blastocoel, a fluid-filled cavity w...
Delamination of chick cephalic neural crest cells requires an MMP14-dependent downregulation of Cadherin-6B [0.03%]
MMP14依赖的Cadherin-6B下调在鸡头神经嵴细胞的层离中起作用
Cyril Andrieu,Cathy Danesin,Audrey Montigny et al.
Cyril Andrieu et al.
Matrix Metalloproteinases (MMPs) are known for their role in matrix remodeling via their catalytic activities in the extracellular space. Interestingly, these enzymes can also play less expected roles in cell survival, polarity and motility...