Critical Appraisal of "Osteocyte-like differentiation of osteosarcoma by inorganic phosphate" [0.03%]
论“无机磷诱导成骨肉瘤细胞向类osteocyte表型分化”一文的评价研究
Parth Aphale,Himanshu Shekhar,Shashank Dokania
Parth Aphale
fam20b-dependent proteoglycans do not affect dermal bone formation and fin regeneration, but Bmp signalling promotes fin regenerate outgrowth [0.03%]
FAM20B依赖的蛋白聚糖不影响真皮骨形成和鳍再生，但BMP信号促进鳍再生的生长发育
Elham Koosha,Qian Ma,Laura Romo Dorantes et al.
Elham Koosha et al.
The role of proteoglycans (PGs) in regulating growth factor signalling during endochondral ossification, or formation of bone around a cartilage template, is established. However, whether PGs regulate other skeletal processes, like intramem...
Mirco Galiè
Mirco Galiè
The mesenchymal phenotype has long been related to either the structural support or the transition between two subsequent epithelial stages. Although this view is generally correct in certain contexts of embryonic development as well as of ...
Osteocyte-like differentiation of osteosarcoma by inorganic phosphate [0.03%]
无机磷酸盐诱导骨肉瘤细胞向成骨细胞样细胞分化的研究
Yuya Suzuki,Makoto Takeuchi,Sumie Koike et al.
Yuya Suzuki et al.
Osteosarcoma (OS) cells that deviate from the normal osteogenic differentiation pathway from mesenchymal stem cells (MSCs) to less migratory osteocytes are in an undifferentiated and highly malignant state. β-glycerophosphate (β-gp) is co...
Regenerative medicine and tissue engineering potential of mesenchymal stem cells exosomes-derived microRNAs [0.03%]
间充质干细胞外泌体衍生的微小RNA在再生医学和组织工程中的潜力
Navidreza Shayan,Negin Ghiyasimoghaddam,Nima Ameli et al.
Navidreza Shayan et al.
Mesenchymal stem cells (MSCs) have been revealed as an appropriate candidate for cell-based therapies by isolation from a different range of sources such as bone marrow, umbilical cord, adipose, liver, and orofacial tissues. MSCs showed low...
EMT: from embryogenesis, through cancer progression, to the development of carcinosarcoma [0.03%]
EMT：从胚胎发生到癌症进展再到癌肉瘤的发展
Marcello Guarino
Marcello Guarino
Epithelial cells are tightly connected to one another by intercellular junctions which prevent much of their motility, and have distinct apical-basal cell polarity, with their basal pole facing the basement membrane; they form mono- or mult...
Inhibition of Atg13-mediated autophagy enhances the anti-osteoclastogenic effect of sirolimus by counteracting its pro-autophagic activity [0.03%]
通过对抗其促自噬活性来增强西罗莫司的抗破骨细胞生成作用：抑制Atg13介导的自噬
Tingwei Gao,Jiankun Wang,Jiajia Wang et al.
Tingwei Gao et al.
Sirolimus can inhibit osteoclastogenesis. But sirolimus-activated autophagy is a favorable factor for osteoclastogenesis. This study aimed to explore the significance of autophagy in sirolimus-regulated osteoclastogenesis. Our results confi...
NONO regulates monocyte-macrophage lineage differentiation through a potential PI3K/AKT-dependent mechanism [0.03%]
NONO通过潜在的PI3K/AKT依赖机制调节单核细胞-巨噬细胞系分化
Xiu-Rong Wei,Dan Hu,Zi-Jiang Yang et al.
Xiu-Rong Wei et al.
Non-POU domain containing octamer binding protein (NONO) is a multifunctional nuclear protein which plays important roles in regulating nuclear processes such as transcription and splicing. We aimed to delineate the effects and the underlyi...
Emerging role of alternative splicing in oral and maxillofacial development [0.03%]
口腔和颌面部发育中可变剪接作用的新角色
Yinyu Fu,Bo Yang,Ling Lai et al.
Yinyu Fu et al.
The excision of introns and subsequent ligation of exons in precursor messenger RNA (pre-mRNA) is a fundamental mechanism requisite for the expression of eukaryotic genes. Alternative splicing (AS) serves as a potent amplifying factor, augm...
Naomi M Calhoun,Richard R Behringer
Naomi M Calhoun
WNT7A regulates numerous developmental processes. It can activate canonical and non-canonical signaling depending on context. It is expressed in the developing central nervous system, limb buds, reproductive organs, and other tissues. Spont...