Oxidative-stress induced Bmp2-Smad1/5/8 signaling dependent differentiation of early cardiomyocytes from embryonic and adult epicardial cells [0.03%]
氧化应激诱导的Bmp2-Smad1/5/8信号依赖性胚胎和成年心外膜细胞早期心肌细胞分化
Madhurima Ghosh,Riffat Khanam,Arunima Sengupta et al.
Madhurima Ghosh et al.
Heart failure has become a major life-threatening cause affecting millions globally, characterized by the permanent loss of adult functional cardiomyocytes leading to fibrosis which ultimately deprives the heart of its functional efficacy. ...
Type 1 collagen: Synthesis, structure and key functions in bone mineralization [0.03%]
第一型胶原蛋白：合成，结构及其在骨矿物化中的关键作用
Vimalraj Selvaraj,Saravanan Sekaran,Anuradha Dhanasekaran et al.
Vimalraj Selvaraj et al.
Collagen is a highly abundant protein in the extracellular matrix of humans and mammals, and it plays a critical role in maintaining the body's structural integrity. Type I collagen is the most prevalent collagen type and is essential for t...
The road to gene manipulation in the mouse: Jean Brachet Memorial Lecture of the International Society of Differentiation (delivered June 21, 2023 at Cold Spring Harbor Laboratory) [0.03%]
在小鼠中操纵基因的道路：国际分化学会为纪念Jean Brachet而举行的讲座（于2023年6月21日在冷泉港实验室举行）
Virginia Papaioannou
Virginia Papaioannou
Genetic manipulation in mammals has progressed rapidly in the past decade with the advent of CRISPR-Cas gene editing tools, promising profound impacts on the understanding of human development, health and disease. However, many years of res...
Yuanxiang Zhao,Zachary Skovgaard,Qinyi Wang
Yuanxiang Zhao
Epigenetic regulation is a critical component of lineage determination. Adipogenesis is the process through which uncommitted stem cells or adipogenic precursor cells differentiate into adipocytes, the most abundant cell type of the adipose...
BBS genes are involved in accelerated proliferation and early differentiation of BBS-related tissues [0.03%]
BBS基因与相关组织的加速增殖和早期分化有关
Avital Horwitz,Noa Levi-Carmel,Olga Shnaider et al.
Avital Horwitz et al.
Bardet-Biedl syndrome (BBS) is an inherited disorder primarily ciliopathy with pleiotropic multi-systemic phenotypic involvement, including adipose, nerve, retinal, kidney, Etc. Consequently, it is characterized by obesity, cognitive impair...
Expression patterns of CYP26A1, FGF8, CDKN1A, and NPVF in the developing rhesus monkey retina [0.03%]
发育中的恒河猴视网膜中CYP26A1、FGF8、CDKN1A和NPVF的表达模式
Miranda R Krueger,Elizabeth Fishman-Williams,Sergi Simó et al.
Miranda R Krueger et al.
The fovea centralis (fovea) is a specialized region of the primate retina that plays crucial roles in high-resolution visual acuity and color perception. The fovea is characterized by a high density of cone photoreceptors and no rods, and u...
Differentiation of Uc-MSCs into insulin secreting islet-like clusters by trypsin through TGF-beta signaling pathway [0.03%]
胰蛋白酶通过TGF-β信号通路分化UC-MSC为分泌胰岛素的类胰岛细胞簇
Feirong Huang,Jiashuang Lai,Lixia Qian et al.
Feirong Huang et al.
Differentiation of human umbilical cord mesenchymal stem cells (Uc-MSCs) into islet-like clusters which are capable of synthesizing and secreting insulin can potentially serve as donors for islet transplantation in the patient deficiency in...
Zhe-Long Jin,KangHe Xu,Jonghun Kim et al.
Zhe-Long Jin et al.
Hepatic organoids might provide a golden opportunity for realizing precision medicine in various hepatic diseases. Previously described hepatic organoid protocols from pluripotent stem cells rely on complicated multiple differentiation step...
Martyna Biadun,Radoslaw Karelus,Daniel Krowarsch et al.
Martyna Biadun et al.
Fibroblast growth factor 12 (FGF12) belongs to the fibroblast growth factor homologous factors (FHF) subfamily, which is also known as the FGF11 subfamily. The human FGF12 gene is located on chromosome 3 and consists of four introns and fiv...
Francesca Rochais,Robert G Kelly
Francesca Rochais
Fibroblast growth factor 10 (FGF10) is a major morphoregulatory factor that plays essential signaling roles during vertebrate multiorgan development and homeostasis. FGF10 is predominantly expressed in mesenchymal cells and signals though F...