Development and validation of a trans-ancestry polygenic risk score for type 1 diabetes [0.03%]
一种用于1型糖尿病的跨祖先多基因风险评分的研发与验证
Basile Jumentier,Hui-Qi Qu,Tianyuan Lu et al.
Basile Jumentier et al.
Aims/hypothesis: The high heritability of type 1 diabetes has enabled the development of polygenic risk scores (PRSs) as disease risk screening tools. PRSs can identify individuals at the highest genetic risk in a populat...
The microbial tryptophan metabolite indole acts on the gastrointestinal tract to improve glucose homeostasis in a mouse model of diabetes by enhancing GLP-1 secretion and L cell differentiation [0.03%]
糖尿病小鼠模型中的肠道微生物代谢产物吲哚通过促进GLP-1的释放和L细胞分化来改善葡萄糖稳态
Phyllis Phuah,Mariana Norton,Sijing Cheng et al.
Phyllis Phuah et al.
Aims/hypothesis: Growing evidence implicates gut microbiota-derived metabolites in metabolic homeostasis. Indole, a microbial tryptophan metabolite, has been reported to enhance glucagon-like peptide-1 (GLP-1) secretion i...
Systematic analysis of loss-of-function variants across MODY genes demonstrates gene-specific effects and expands the spectrum of INS variants causing MODY [0.03%]
系统分析MODY基因的丧失功能突变体，展示出特定基因的效果，并且在INS变异体导致糖尿病方面的光谱扩展了研究结果
Thomas W Laver,Aparajita Sriram,Matthew N Wakeling et al.
Thomas W Laver et al.
Aims/hypothesis: Accurate interpretation of loss-of-function (LOF) variants in MODY genes is essential for diagnosis but remains challenging, particularly for variants that are predicted to escape nonsense-mediated decay ...
A diabetes-induced change of MDM2 SNP309T→G contributes to aberrant retinal angiogenesis [0.03%]
糖尿病引起的SNP309T→G突变会导致视网膜异常血管生成
Gaoen Ma,Wenyi Wu,Yajian Duan et al.
Gaoen Ma et al.
Aims/hypothesis: The 309G SNP in the second promoter of the gene encoding mouse double minute 2 (MDM2) has been implicated in multiple human diseases. The aims of this study were to determine whether MDM2 SNP309G is assoc...
Jean Claude Katte,Charlotte Bavuma,Sarah H Wild et al.
Jean Claude Katte et al.
Atypical diabetes subtypes and presentations are disproportionately prevalent in populations of African and Asian ancestry. This review discusses the epidemiology, clinical presentation, aetiopathogenesis and management of four atypical dia...
Beyond BMI: the need for improved adiposity assessment in studying subclinical cardiovascular autonomic neuropathy in children with type 1 diabetes. Reply to Risi R, Buzzetti R, Maddaloni E [letter] [0.03%]
超越体重指数:BMI在儿童1型糖尿病亚临床心血管自主神经病变研究中的局限及改善脂肪评估方法的必要性回信答复Risi R、Buzzetti R、Maddaloni E等人的来信
Frida Dangardt,Gun Forsander,Ebba Bergdahl
Frida Dangardt
Beyond BMI: the need for improved adiposity assessment in studying subclinical cardiovascular autonomic neuropathy in children with type 1 diabetes [0.03%]
超越BMI：在儿童1型糖尿病亚临床心血管自主神经病变研究中改善肥胖评估的必要性
Renata Risi,Raffaella Buzzetti,Ernesto Maddaloni
Renata Risi
GlucoseGo: a simple tool to predict hypoglycaemia during exercise in type 1 diabetes [0.03%]
glucosego：一个工具，用于在1型糖尿病运动过程中预测低血糖风险
Catherine L Russon,Michael J Allen,Emma Cockcroft et al.
Catherine L Russon et al.
Aims/hypothesis: This study aimed to develop an accessible tool, derived using machine learning, to predict hypoglycaemia risk at the start of exercise and to provide clear, rapid risk assessment to support safer particip...
The diabetes-associated K+ channel TALK-2 controls human beta cell endoplasmic reticulum Ca2+ handling, which promotes basal insulin release and limits glucose-stimulated insulin secretion [0.03%]
糖尿病相关的钾通道TALK-2控制人类β细胞内质网Ca2+的处理，从而促进基础胰岛素释放并限制葡萄糖刺激的胰岛素分泌
Jordyn R Dobson,Prasanna K Dadi,Matthew T Dickerson et al.
Jordyn R Dobson et al.
Aims/hypothesis: The two-pore domain K+ channel TWIK1-related alkalinisation-activated K+ channel 2 (TALK-2) is encoded by KCNK17, which is one of the most abundant beta cell K+ channel transcripts that also shows high is...
Canagliflozin attenuates CMR-quantified myocardial fibrosis in individuals with type 2 diabetes mellitus at high cardiovascular risk: a randomised open-label controlled trial [0.03%]
卡格列净可减轻心血管疾病高危2型糖尿病患者的定量磁共振成像心肌纤维化：一项随机、开放标签的对照试验
Hongmei Yan,Jiaojiao Liu,Zhitian Zhang et al.
Hongmei Yan et al.
Aims/hypothesis: We aimed to investigate canagliflozin's effects on myocardial fibrosis, cardiac structure and function, and microcirculation in high-cardiovascular-risk type 2 diabetes mellitus through cardiac magnetic r...