Alice L J Carr,Hannah Sutton,Rikke M Agesen et al.
Alice L J Carr et al.
Continuous glucose monitoring (CGM) has transformed diabetes management by providing continuous, real-time insights into glucose dynamics, while enhancing the lived experience of individuals with type 1 diabetes. In established type 1 diabe...
Early meal timing improves nocturnal glucose in pregnancies complicated by gestational diabetes [0.03%]
早孕期时间的进餐改善妊娠糖尿病患者的夜间血糖水平
Hannah A Cunningham,Lucy Ward,Matthew P Butler et al.
Hannah A Cunningham et al.
Aims/hypothesis: Gestational diabetes (GDM) results in adverse outcomes for the pregnant individual and neonate. Lifestyle modifications are first-line interventions used to achieve pregnancy-specific glucose targets. We ...
Mitochondrial cristae density is increased following high-intensity interval training in men with type 2 diabetes [0.03%]
高强度间歇训练可增加2型糖尿病男性的线粒体嵴密度
Martin E de Almeida,Niels Ørtenblad,Amalie B Platz et al.
Martin E de Almeida et al.
Aims/hypothesis: Mitochondrial cristae architecture is a key determinant of oxidative capacity in skeletal muscle. While mitochondrial dysfunction is common in type 2 diabetes, it remains unclear whether cristae density i...
Endoplasmic reticulum-mitochondria contact sites are signalling hubs connecting nutrient sensing and GLP-1 secretion in L cells of the mouse gut: from physiology to obesity and type 2 diabetes [0.03%]
内质网-线粒体接触位点是小肠L细胞中连接营养感应和GLP-1分泌的信号中心：从生理学到肥胖症和2型糖尿病
Alexandre Humbert,Margaux Nawrot,Nadia Bendridi et al.
Alexandre Humbert et al.
Aims/hypothesis: Postprandial glucagon-like peptide-1 (GLP-1) secretion by enteroendocrine L cells of the gut plays an important role in glucose homeostasis, thus representing a therapeutic option of ever-growing signific...
Development and validation of a trans-ancestry polygenic risk score for type 1 diabetes [0.03%]
一种用于1型糖尿病的跨祖先多基因风险评分的研发与验证
Basile Jumentier,Hui-Qi Qu,Tianyuan Lu et al.
Basile Jumentier et al.
Aims/hypothesis: The high heritability of type 1 diabetes has enabled the development of polygenic risk scores (PRSs) as disease risk screening tools. PRSs can identify individuals at the highest genetic risk in a populat...
The microbial tryptophan metabolite indole acts on the gastrointestinal tract to improve glucose homeostasis in a mouse model of diabetes by enhancing GLP-1 secretion and L cell differentiation [0.03%]
糖尿病小鼠模型中的肠道微生物代谢产物吲哚通过促进GLP-1的释放和L细胞分化来改善葡萄糖稳态
Phyllis Phuah,Mariana Norton,Sijing Cheng et al.
Phyllis Phuah et al.
Aims/hypothesis: Growing evidence implicates gut microbiota-derived metabolites in metabolic homeostasis. Indole, a microbial tryptophan metabolite, has been reported to enhance glucagon-like peptide-1 (GLP-1) secretion i...
Systematic analysis of loss-of-function variants across MODY genes demonstrates gene-specific effects and expands the spectrum of INS variants causing MODY [0.03%]
系统分析MODY基因的丧失功能突变体，展示出特定基因的效果，并且在INS变异体导致糖尿病方面的光谱扩展了研究结果
Thomas W Laver,Aparajita Sriram,Matthew N Wakeling et al.
Thomas W Laver et al.
Aims/hypothesis: Accurate interpretation of loss-of-function (LOF) variants in MODY genes is essential for diagnosis but remains challenging, particularly for variants that are predicted to escape nonsense-mediated decay ...
A diabetes-induced change of MDM2 SNP309T→G contributes to aberrant retinal angiogenesis [0.03%]
糖尿病引起的SNP309T→G突变会导致视网膜异常血管生成
Gaoen Ma,Wenyi Wu,Yajian Duan et al.
Gaoen Ma et al.
Aims/hypothesis: The 309G SNP in the second promoter of the gene encoding mouse double minute 2 (MDM2) has been implicated in multiple human diseases. The aims of this study were to determine whether MDM2 SNP309G is assoc...
Jean Claude Katte,Charlotte Bavuma,Sarah H Wild et al.
Jean Claude Katte et al.
Atypical diabetes subtypes and presentations are disproportionately prevalent in populations of African and Asian ancestry. This review discusses the epidemiology, clinical presentation, aetiopathogenesis and management of four atypical dia...
Beyond BMI: the need for improved adiposity assessment in studying subclinical cardiovascular autonomic neuropathy in children with type 1 diabetes. Reply to Risi R, Buzzetti R, Maddaloni E [letter] [0.03%]
超越体重指数:BMI在儿童1型糖尿病亚临床心血管自主神经病变研究中的局限及改善脂肪评估方法的必要性回信答复Risi R、Buzzetti R、Maddaloni E等人的来信
Frida Dangardt,Gun Forsander,Ebba Bergdahl
Frida Dangardt