Updated glucose management indicator (GMI) better aligns with HbA1c than current GMI: implications for clinical practice and reporting [0.03%]
Richard M Bergenstal,Yongjin Xu,Timothy C Dunn et al.
Richard M Bergenstal et al.
Aims/hypothesis: The continuous glucose monitoring (CGM)-derived glucose management indicator (GMI) is valuable to people with diabetes, and healthcare professionals and organisations for assessing overall glucose levels,...
Mikael Rydén
Mikael Rydén
White adipose tissue (WAT) is a remarkably plastic organ integrating metabolic, endocrine and immune functions. In humans, perturbations in adipocyte turnover, size regulation and cellular heterogeneity underpin the transition from metaboli...
Bmal1 overexpression in suprachiasmatic nucleus protects from retinal neurovascular deficits in a mouse model of diabetes [0.03%]
Neha Mahajan,Qianyi Luo,Jodi Lukkes et al.
Neha Mahajan et al.
Aims/hypothesis: The suprachiasmatic nucleus regulates circadian rhythms and influences physiological and behavioural functions. Clock genes not only play a critical role in orchestrating circadian rhythms, but also regul...
Exercise snacks performed in real-world settings reduce postprandial hyperglycaemia and glycaemic variability in individuals living with type 2 diabetes: a randomised crossover study [0.03%]
Fiona J Babir,Alexis Marcotte-Chénard,Roderick E Sandilands et al.
Fiona J Babir et al.
Aims/hypothesis: Using a randomised, crossover design, we investigated whether exercise snacks could improve indices of glucose regulation assessed by continuous glucose monitoring, compared with an equivalent no-exercise...
Time delays between fingerstick glucose measurements and correctional insulin administration in the hospital: do they really matter? [0.03%]
Kristen L Flint,Alana Fahey,Rebecca Longo et al.
Kristen L Flint et al.
Aims/hypothesis: Time delays exist between inpatient blood glucose measurements, insulin administration and meal timing. The clinical impacts of time delay on insulin dosing and hypoglycaemia risk have not been fully eval...
Inequalities in type 2 diabetes incidence in a multiethnic population: a cohort study investigating the impact of ethnicity, migration and mental health comorbidities [0.03%]
Diana Shamsutdinova,Daniel Stahl,Jayati Das-Munshi
Diana Shamsutdinova
Aims/hypothesis: Ethnic disparities in the incidence of type 2 diabetes mellitus are well documented in multiethnic urban populations, but the contributions of migration status and mental health are less well understood. ...
Age- and sex-specific trends in dementia mortality among people with and without diabetes: a multi-country population-based analysis [0.03%]
Kanika Mehta,Jedidiah I Morton,Lei Chen et al.
Kanika Mehta et al.
Aims/hypothesis: Large-scale data on age- and sex-specific dementia mortality trends among people with diabetes remain limited, as most previous studies have been restricted to single countries or have not distinguished m...
Beta cell microRNAs function as molecular hubs of type 1 diabetes pathogenesis and as biomarkers of diabetes risk [0.03%]
Farooq Syed,Preethi Krishnan,Garrick Chang et al.
Farooq Syed et al.
Aims/hypothesis: Clinically actionable biomarkers that accurately reflect the health status of the beta cell are needed to improve risk stratification and optimise the timing of interventions in type 1 diabetes. We hypoth...
Oral glucose absorption is enhanced in early metabolic dysfunction-associated steatotic liver disease [0.03%]
Domenico Tricò,Tongzhi Wu,Noemi Cimbalo et al.
Domenico Tricò et al.
Aims/hypothesis: Hepatic glucose flux plays a crucial role in the progression of metabolic dysfunction-associated steatotic liver disease (MASLD), promoting de novo lipogenesis, inflammation and fibrosis. This study aimed...