Development and application of type 1 diabetes polygenic scores across diverse populations [0.03%]
跨不同人群的1型糖尿病多基因评分的发展和应用
Despoina Manousaki,Dominika A Michalek,Hui-Qi Qu et al.
Despoina Manousaki et al.
Type 1 diabetes is highly influenced by genetic risk factors, especially variation in the HLA genes. Polygenic scores can strongly predict type 1 diabetes risk by integrating variants across the genome. Most polygenic scores perform best in...
High prevalence of low faecal elastase levels in individuals with type 1 diabetes is associated with diabetes duration but not with marked alterations in food intake or clinical symptoms [0.03%]
I型糖尿病患者粪便弹性蛋白酶水平低的高流行率与病程有关，但与饮食摄入或临床症状的变化无关
Douwe F de Wit,Coco M Fuhri Snethlage,Johannes H M Levels et al.
Douwe F de Wit et al.
Aims/hypothesis: Although exocrine pancreatic insufficiency (EPI) is thought to be common in type 1 diabetes, little is known about the relationship of EPI with type 1 diabetes parameters or food intake and abdominal comp...
A GLP-1 receptor agonist enhances islet microvascular flow through nitric oxide-dependent mechanisms in a diabetic mouse model: investigation using intravital two-photon imaging [0.03%]
利拉鲁肽通过依赖一氧化氮的机制增强糖尿病小鼠胰岛微血管血流：运用在体双光子成像技术研究
Tomohiko Kimura,Kengo Kidokoro,Yuichiro Iwamoto et al.
Tomohiko Kimura et al.
Aims/hypothesis: Impaired regulation of islet microvascular blood flow has been implicated in beta cell dysfunction in diabetes; this dysregulation is linked to endothelial dysfunction with reduced nitric oxide bioavailab...
Screening and diagnosis of liver disease in diabetes: a guide and evidence-based assessment [0.03%]
糖尿病患者的肝脏疾病筛查与诊断指南及循证评估
Sami F Qadri
Sami F Qadri
Most people with type 2 diabetes have metabolic dysfunction-associated steatotic liver disease (MASLD), yet fewer than 2% experience major adverse liver outcomes within 10 years. Because progression to end-stage liver disease is uncommon, i...
Endometriosis subtypes and risk of type 2 diabetes: the Advancing Research on Cardiovascular Health and Endometriosis Study (ARCHES) retrospective cohort study [0.03%]
子宫内膜异位症亚型与2型糖尿病风险的关系：ARCHES回顾性队列研究
Maggie Fuzak Nunziato,Bin Yan,Karen C Schliep et al.
Maggie Fuzak Nunziato et al.
Aims/hypothesis: Endometriosis is a heterogeneous inflammatory condition that may influence long-term metabolic health. Prior studies have reported largely null associations with type 2 diabetes, potentially missing subty...
Concurrent training is associated with enhanced post-exercise ceramide clearance and fat oxidation capacity in individuals with type 2 diabetes following lifestyle intervention [0.03%]
生活方式干预后并发训练与2型糖尿病患者运动后丝氨酸清除能力和脂肪氧化能力增强有关
Mikael Flockhart,Michael Svensson,Emad Ehtesham et al.
Mikael Flockhart et al.
Aim/hypothesis: This study aimed to investigate whether concurrent training, when added to a palaeolithic-type diet-induced weight loss intervention, is associated with altered physiological responses and circulating lipi...
Predicting future risk of type 1 and type 2 diabetes after gestational diabetes mellitus using polygenic scores: a cohort study [0.03%]
基于多基因评分预测妊娠期糖尿病后1型和2型糖尿病的未来风险：队列研究
Isabella L Jørgensen,Peter Damm,Mette K Andersen et al.
Isabella L Jørgensen et al.
Aims/hypothesis: Women with previous gestational diabetes mellitus (GDM) have an increased risk of developing both type 1 and type 2 diabetes. However, predicting the risk on a personal level is challenging. Polygenic sco...
Incidence and independent risk factors for heart failure in a population-based cohort of 19,892 individuals with newly diagnosed diabetes [0.03%]
基于人群的糖尿病患者心力衰竭的发病率及独立危险因素——19892例新诊断糖尿病患者的队列研究
Carl Lejonberg,Tomasz Czuba,Louise Bennet et al.
Carl Lejonberg et al.
Aims/hypothesis: Heart failure (HF) is a common complication of diabetes, associated with a high mortality rate and a substantial healthcare burden. Residual HF risk persists despite achieving current treatment targets, s...
Metformin protects podocytes by inhibiting the MAPK14-SLC7A11-GPX4 axis and dysregulation of fatty acid metabolism [0.03%]
二甲双胍通过抑制MAPK14-SLC7A11-GPX4轴及脂代谢紊乱发挥保护足细胞的作用
Shi Qiu,Dandan Xie,Sifan Guo et al.
Shi Qiu et al.
Aims/hypothesis: Diabetic nephropathy is a leading cause of end-stage renal disease, with podocyte loss being a critical event in its progression. However, the dominant molecular mechanism driving podocyte loss remains el...
Metabolic implications of hepatic, pancreatic and abdominal adipose tissue depots in Asian Indians across normoglycaemia, prediabetes and type 2 diabetes [0.03%]
亚洲印度人在正常血糖、糖尿病前期和2型糖尿病中肝脏、胰腺和腹部脂肪组织的代谢意义
Amerta Ghosh,Koel Dutta,Surya Prakash Bhatt et al.
Amerta Ghosh et al.
Aims/hypothesis: The aim of this study was to evaluate hepatic, pancreatic and abdominal fat depots across glycaemic categories in Asian Indians with matched BMI, and to identify predictors of dysglycaemia. ...