Metabolic drivers of MASLD and MASH: from hormonal imbalance to fibrosis [0.03%]
MASLD和MASH的代谢驱动因素：从激素失衡到纤维化
Amalia Gastaldelli,Egeria Scoditti,Maria Paula Macedo
Amalia Gastaldelli
Metabolic dysfunction-associated steatotic liver disease (MASLD) and its more severe and aggressive form, metabolic dysfunction-associated steatohepatitis (MASH), represent liver-specific consequences of systemic metabolic dysfunction. This...
Somatostatin receptors shape insulin and glucagon output within the pancreatic islet in mice through direct and paracrine effects [0.03%]
生长抑素受体通过直接和旁分泌效应塑造小鼠胰岛中胰岛素和胰高血糖素的释放
Ryan G Hart,Jordan J Lee,Karen Zhai et al.
Ryan G Hart et al.
Aims/hypothesis: Pancreatic delta cells secrete somatostatin (SST), which can inhibit both alpha cells and beta cells of the pancreatic islet. By controlling insulin and glucagon release, delta cells play an important rol...
Gender differences in hypoglycaemia in type 1 and insulin-treated type 2 diabetes: the Hypo-METRICS study [0.03%]
Hypo-METRICS研究中的1型和接受胰岛素治疗的2型糖尿病患者的低血糖性别差异
Aisling McCarthy,Gráinne Kent,Jonah Thomas et al.
Aisling McCarthy et al.
Aims/hypothesis: The aim of this study was to explore associations between gender and hypoglycaemia experience among people with type 1 diabetes or insulin-treated type 2 diabetes in a free-living environment in the Hypo-...
Pharmacological inhibition of perforin dampens CD8+ T cell-mediated beta cell destruction in autoimmune diabetes in mice [0.03%]
药理学抑制穿孔素可减弱小鼠自身免疫糖尿病中CD8+t细胞介导的β细胞破坏作用
Prerak M Trivedi,Tara Catterall,Vivien R Sutton et al.
Prerak M Trivedi et al.
Aims/hypothesis: CD8⁺ T cells are key mediators of beta cell destruction in type 1 diabetes, employing the perforin/granzyme and Fas/Fas ligand pathways. Evidence from our studies and others indicates that perforin plays...
Gardnerella enrichment in the vaginal microbiome of women with gestational diabetes mellitus is associated with lower fetal birthweight percentiles [0.03%]
加德纳菌在妊娠糖尿病妇女阴道微生物群中的富集与胎儿体重百分位数较低有关
Yilin Fu,Nary Long,Phannaroat Sourn et al.
Yilin Fu et al.
Aims/hypothesis: We aimed to characterise alterations in the late-pregnancy vaginal microbiota in women with gestational diabetes mellitus (GDM), and to examine their associations with maternal glycaemic status and fetal ...
Fetal growth is driven by a bimodal fetal beta cell response and reshaped by a ketogenic diet in a mouse model of maternal diabetes [0.03%]
小鼠母亲糖尿病模型中的胎儿生长由胎盘β细胞的双峰反应驱动并被生酮饮食重塑
Omer Cohenshtam,Amnon Zung,Amy Yu et al.
Omer Cohenshtam et al.
Aims/hypothesis: Maternal diabetes confers two opposing risks to fetal growth, resulting in macrosomia in mild cases and intrauterine growth restriction (IUGR) in severe cases. The mechanisms governing these divergent res...
The protective effect of high-intensity interval exercise compared with continuous moderate exercise on glycaemic decline is more pronounced in the postabsorptive vs postprandial state in adults with type 1 diabetes: a randomised crossover trial [0.03%]
与持续中等强度运动相比，高强度间歇运动对1型糖尿病成人吸收后血糖下降的保护作用比餐后更明显：一项随机交叉试验
Angéline Melin,Elodie Lespagnol,Adrien Combes et al.
Angéline Melin et al.
Aims/hypothesis: The objective of this randomised crossover study was to determine, in adults with type 1 diabetes, whether the glycaemic effects of high-intensity interval exercise (HIIE) vs moderate-intensity continuous...
Unravelling the developmental origins of cystic fibrosis-related diabetes [0.03%]
解开囊性纤维化相关糖尿病的发病机制谜团
Alex Cho,Maria Cristina Nostro
Alex Cho
Cystic fibrosis (CF)-related diabetes (CFRD) is a growing and evolving concern for people living with cystic fibrosis. As its own unique clinical entity, there is an urgent need to better understand this complex health challenge to improve ...
Josh Bilson,Hanieh Yaghootkar
Josh Bilson
Metabolic dysfunction-associated steatotic liver disease (MASLD) is highly prevalent in people with type 2 diabetes and represents a major contributor to liver-related and extrahepatic morbidity and mortality. Despite this strong epidemiolo...
SARS-CoV-2 infection and COVID-19 vaccination and the risk for new-onset type 1 diabetes: a register-based population study in Sweden [0.03%]
SARS-CoV-2感染和COVID-19疫苗接种与新发1型糖尿病风险：瑞典注册人群研究
Huiqi Li,Lisa Morris,Maria Bygdell et al.
Huiqi Li et al.
Aims/hypothesis: Reports from several countries suggested increased incidence of type 1 diabetes during the COVID-19 pandemic, but causality has remained unclear. We investigated incident type 1 diabetes related to SARS-C...