Sarah H Wild,Jeffrey V Lazarus,C Wendy Spearman et al.
Sarah H Wild et al.
Over the last decade it has become clear that obesity and type 2 diabetes are key to the aetiology, pathogenesis and outcomes of metabolic dysfunction-associated steatotic liver disease (MASLD). The considerable current and potential burden...
Human islet amyloid polypeptide aggregation upregulates the mitochondrial cholesterol transport protein StAR and induces mitochondrial dysfunction in beta cells [0.03%]
人胰岛淀粉样多肽聚集上调β细胞中的胆固醇转运蛋白StAR并诱导线粒体功能障碍
Meghan F Hogan,Rehana Akter,Alfred C Aplin et al.
Meghan F Hogan et al.
Aims/hypothesis: Loss of islet beta cell function and mass are critical in the pathogenesis of type 2 diabetes, a disease in which ~90% of individuals exhibit islet amyloid deposition. Amyloid deposits comprise the normal...
Reappraising gestational hyperglycaemia: a manifestation of lifelong glycaemia or a correlation of glycaemic indices across life stages. Reply to Joshi SR, Samajdar SS, Mohan V [letter] [0.03%]
重新评估妊娠期高血糖：一生中的血糖表现还是生命不同阶段糖代谢指标的相关性？对乔希S R、萨马贾达尔S S、莫汗V的来信答复
Chittaranjan S Yajnik,Souvik Bandopadhyay,Rashmi B Prasad et al.
Chittaranjan S Yajnik et al.
Reappraising gestational hyperglycaemia: a manifestation of lifelong glycaemia or a correlation of glycaemic indices across life stages [0.03%]
重新评估妊娠期高血糖：一生中的血糖表现还是生命不同阶段血糖指标的相关性？
Shashank R Joshi,Shambo S Samajdar,Viswanathan Mohan
Shashank R Joshi
GLP1-E2 therapy delays autoimmune diabetes in late-stage prediabetic NOD mice and potentiates low-dose anti-CD3 therapy for enhanced disease protection [0.03%]
GLP1-E2疗法可延缓NOD糖尿病前期小鼠向糖尿病的进展并增强低剂量抗-CD3治疗以提高保护效果
Laure Degroote,Jędrzej Chrzanowski,Pierre Lemaitre et al.
Laure Degroote et al.
Aims/hypothesis: Anti-CD3 monoclonal antibody (aCD3) delays progression to stage 3 type 1 diabetes in high-risk individuals by modulating autoimmune activity. Nevertheless, responses remain variable and transient, with th...
Staging intermediate hyperglycaemia for type 2 diabetes prevention: the ELSA-Brasil study [0.03%]
巴西流行病学研究：用于预防2型糖尿病的中间糖化血红蛋白水平：ELSA-Brazil研究
Paula A Bracco,Maria I Schmidt,Danilo de Paula et al.
Paula A Bracco et al.
Aims/hypothesis: We aimed to evaluate stages in the development of type 2 diabetes by combining fasting plasma glucose (FPG) with 1 h plasma glucose (PG) or HbA1c levels. ...
Integrating immune-cell transcriptomic data with Mendelian randomisation reveals novel causal genes for type 2 diabetes and its complications [0.03%]
整合免疫细胞转录组数据与孟德尔随机化分析揭示新的2型糖尿病及其并发症的致病基因
Yilan Ding,Haoyu Liu,Lei Jiang et al.
Yilan Ding et al.
Aims/hypothesis: The aim of this study was to facilitate the fine classification of diabetic complications and the prioritisation of drug targets via immune-cell-related gene expression data, distinguishing cell-type-rela...
Nocturnal fat oxidation is lower in older individuals with overweight/obesity, including those with type 2 diabetes, and is associated with fasting triglyceride levels [0.03%]
超重或肥胖的老年人（包括2型糖尿病患者）夜间脂肪氧化降低并与空腹甘油三酯水平相关
Soraya S de Kam,Jeroen H P M van der Velde,Anna Veelen et al.
Soraya S de Kam et al.
Aims/hypothesis: We previously showed that nocturnal fat oxidation is reduced in older individuals with overweight/obesity and impaired glucose tolerance and insulin sensitivity compared with young lean individuals. Here,...
Sian L Grace,Elinor Balch,Vito Lampasona et al.
Sian L Grace et al.
The impact of automated insulin delivery on glucose management in people with diabetes and advanced chronic kidney disease [0.03%]
自动化胰岛素输注对糖尿病合并慢性肾脏病患者血糖管理的影响
Jean C Lu,Christine L Meyer-Olesen,Bella Halim et al.
Jean C Lu et al.
Aims/hypothesis: Chronic kidney disease (CKD) complicates insulin dosing and increases glycaemic instability in diabetes. We aimed to compare feasibility, safety and efficacy of automated insulin delivery (AID) with usual...