Sing-Young Chen,Christiana Lekka,Jonas Lemvig et al.
Sing-Young Chen et al.
Pancreatic islets of Langerhans are central to the pathogenesis of all major forms of diabetes. The ability to study human islets ex vivo has advanced our understanding of diabetes and aided in the development of novel therapeutics. However...
Psychosocial implications, acceptability and ethics of screening for paediatric type 1 diabetes: a systematic review and mixed methods evidence synthesis [0.03%]
儿童1型糖尿病筛查的心理社会影响、可接受性和伦理问题：系统评价和混合方法证据合成
Lauren M Quinn,David Stanley,Francesca Milano et al.
Lauren M Quinn et al.
Aims/hypothesis: Paediatric population screening for type 1 diabetes is emerging internationally. It is critically important to understand the acceptability of screening to inform these initiatives. In this systematic rev...
Gestational diabetes and risk of type 2 diabetes: exploring the role of the gut microbiome in the Hispanic Community Health Study/Study of Latinos (HCHS/SOL) [0.03%]
妊娠期糖尿病与2型糖尿病风险的关系：在Hispanic社区健康研究/拉丁裔研究(HCHS/SOL)中探讨肠道微生物组的作用
Yi Wang,Carmen R Isasi,Alison M Stuebe et al.
Yi Wang et al.
Aims/hypothesis: Women with a history of gestational diabetes mellitus (GDM) have an elevated risk of type 2 diabetes in their later life, yet the underlying mechanisms of this remain unclear. We aimed to investigate the ...
SGLT2 inhibitor use and disparities in all-cause mortality in type 2 diabetes: insights from a multi-ethnic population [0.03%]
钠葡萄糖协同转运蛋白2抑制剂的使用以及2型糖尿病患者全因死亡率的族裔差异：多族裔人群研究启示
Lynne Chepulis,Han Gan,David Simmons et al.
Lynne Chepulis et al.
Aims/hypothesis: Sodium-glucose cotransporter 2 inhibitors (SGLT2i) are known to reduce cardiovascular and all-cause mortality in people with type 2 diabetes, but there are limited data regarding mortality outcomes in dif...
Causal relationship between epigenetic markers and type 2 diabetes in West African populations: a Mendelian randomisation analysis [0.03%]
西非人群中表观遗传标记与2型糖尿病的因果关系：孟德尔随机化分析
Karlijn A C Meeks,Eva L van der Linden,Amy R Bentley et al.
Karlijn A C Meeks et al.
Aims/hypothesis: Evidence for a causal role of DNA methylation sites (CpGs) in type 2 diabetes and glycaemic traits is limited due to the cross-sectional nature of many epigenome-wide association studies (EWAS). In additi...
Updated glucose management indicator (GMI) better aligns with HbA1c than current GMI: implications for clinical practice and reporting [0.03%]
更新后的血糖管理指标(GMI)比当前的GMI更符合HbA1c：对临床实践和报告的影响
Richard M Bergenstal,Yongjin Xu,Timothy C Dunn et al.
Richard M Bergenstal et al.
Aims/hypothesis: The continuous glucose monitoring (CGM)-derived glucose management indicator (GMI) is valuable to people with diabetes, and healthcare professionals and organisations for assessing overall glucose levels,...
Perspectives on human adipose tissue: from cellular mechanisms to clinical complications [0.03%]
人类脂肪组织的研究视角：从细胞机制到临床并发症
Mikael Rydén
Mikael Rydén
White adipose tissue (WAT) is a remarkably plastic organ integrating metabolic, endocrine and immune functions. In humans, perturbations in adipocyte turnover, size regulation and cellular heterogeneity underpin the transition from metaboli...
Bmal1 overexpression in suprachiasmatic nucleus protects from retinal neurovascular deficits in a mouse model of diabetes [0.03%]
BMAL1在视交叉上核过表达可保护糖尿病小鼠模型免受视网膜神经血管缺陷的影响
Neha Mahajan,Qianyi Luo,Jodi Lukkes et al.
Neha Mahajan et al.
Aims/hypothesis: The suprachiasmatic nucleus regulates circadian rhythms and influences physiological and behavioural functions. Clock genes not only play a critical role in orchestrating circadian rhythms, but also regul...
Exercise snacks performed in real-world settings reduce postprandial hyperglycaemia and glycaemic variability in individuals living with type 2 diabetes: a randomised crossover study [0.03%]
在现实环境中进行的锻炼“零食”可降低2型糖尿病患者餐后高血糖和血糖波动：一项随机交叉研究
Fiona J Babir,Alexis Marcotte-Chénard,Roderick E Sandilands et al.
Fiona J Babir et al.
Aims/hypothesis: Using a randomised, crossover design, we investigated whether exercise snacks could improve indices of glucose regulation assessed by continuous glucose monitoring, compared with an equivalent no-exercise...
Time delays between fingerstick glucose measurements and correctional insulin administration in the hospital: do they really matter? [0.03%]
血糖检测与医院中糖尿病患者胰岛素治疗之间的时间延迟有意义吗？
Kristen L Flint,Alana Fahey,Rebecca Longo et al.
Kristen L Flint et al.
Aims/hypothesis: Time delays exist between inpatient blood glucose measurements, insulin administration and meal timing. The clinical impacts of time delay on insulin dosing and hypoglycaemia risk have not been fully eval...