pFIB scores for paediatric MASLD fibrosis are associated with risk of youth-onset type 2 diabetes in children with obesity [0.03%]
肥胖儿童中Pfib评分与青少年2型糖尿病风险相关性研究
Sander Lefere,Resthie R Putri,Pernilla Danielsson et al.
Sander Lefere et al.
Aims/hypothesis: Youth-onset type 2 diabetes is an aggressive phenotype of metabolic disease, yet tools to identify children with obesity at highest short-term risk are limited. We evaluated whether the paediatric liver f...
Acute mild cold exposure with shivering reduces 24 h glucose levels in individuals with type 2 diabetes but not prediabetes [0.03%]
短期冷暴露引发寒战可降低2型糖尿病患者的血糖水平，但对糖耐量受损患者无效
Dzhansel Hashim,Johanna A Jörgensen,Tineke van de Weijer et al.
Dzhansel Hashim et al.
Aims/hypothesis: Repeated cold exposure with shivering has been proposed as a potential strategy to enhance glucose metabolism by increasing energy expenditure and substrate utilisation. However, acute effects/benefits of...
Norbert Stefan,Giovanni Targher
Norbert Stefan
Metabolic dysfunction-associated steatotic liver disease (MASLD) includes a spectrum of progressive liver conditions ranging from isolated steatosis to metabolic dysfunction-associated steatohepatitis (MASH), advanced fibrosis and cirrhosis...
Relationship between participant-reported outcomes, residual beta cell function and metabolic parameters in youth with newly diagnosed type 1 diabetes [0.03%]
新诊断1型糖尿病青少年患者报告结果、残存胰岛β细胞功能与代谢参数之间的关系
Peter N Taylor,Wai-Yee Cheung,Joe Lagorio Price et al.
Peter N Taylor et al.
Aims/hypothesis: Clinical trials of interventions to preserve beta cell function in new-onset type 1 diabetes frequently employ participant-reported outcome measures (PROMs). However, the expected changes in PROMs scores ...
Dapagliflozin does not impair LDL catabolism and induces a shift towards a closer to normal VLDL1/VLDL2 catabolism in individuals with type 2 diabetes: a randomised in vivo kinetic study [0.03%]
达格列净不影响2型糖尿病患者的LDL清除，并可使更接近正常人的VLDL1/VLDL2代谢模式：一项随机体内动力学研究
Bruno Vergès,Alexia Rouland,Benjamin Bouillet et al.
Bruno Vergès et al.
Aims/hypothesis: SGLT2 inhibitors reduce atherosclerosis, but their effect on lipid metabolism remains unclear. Animal studies have suggested that SGLT2 inhibitors may decrease LDL catabolism by reducing the hepatic expre...
Tissue origins of the plasma proteomic response to glucose ingestion in humans [0.03%]
人类口服葡萄糖后血浆蛋白质组响应的组织来源
Burulça Uluvar,Alice Williamson,Kristoffer J Kolnes et al.
Burulça Uluvar et al.
Aims/hypothesis: Circulating proteins act as important hormonal signals of nutrient intake. We aimed to systematically characterise the time-resolved proteomic response to glucose ingestion in humans, and to assess its ro...
Liver-to-kidney apolipoprotein J trans-accumulation exacerbates diabetic renal injury by disrupting TFEB-mediated lipid homeostasis [0.03%]
肝源性神经生长因子运载蛋白J通过干扰TFEB介导的脂质稳态向肾脏积累加重糖尿病肾损伤
Shuangdi Duan,Nong Qin,Jiayi Pi et al.
Shuangdi Duan et al.
Aims/hypothesis: Ectopic lipid accumulation in renal tubules induces lipotoxicity and contributes to the progression of diabetic kidney disease (DKD). Apolipoprotein J (ApoJ), a glucose-regulated, liver-derived molecular ...
Marc Jonuscheit,Vera B Schrauwen-Hinderling
Marc Jonuscheit
Non-invasive imaging is central to the diagnosis and staging of metabolic dysfunction-associated steatotic liver disease (MASLD). Various non-invasive means are used to reliably diagnose steatosis, whereas liver biopsy remains the gold stan...
Dementia in type 2 diabetes: risk factors, disease processes and opportunities for prevention across the lifespan [0.03%]
2型糖尿病患者的痴呆症：一生中影响发病的风险因素、疾病进程及预防机会
Jan F de Leijer,Geert Jan Biessels,Frank L J Visseren et al.
Jan F de Leijer et al.
People with type 2 diabetes have a 60-70% higher risk of developing dementia than those without diabetes. Given the increasing number of older people living with diabetes, preventing dementia in this population is becoming increasingly impo...
Premeal insulin administration lowers postprandial blood glucose and increases myocardial microvascular blood flow in people with type 1 diabetes: a randomised, crossover clinical trial [0.03%]
餐前注射胰岛素可降低1型糖尿病患者的餐后血糖并增加心肌微血管血流：随机交叉临床试验
William B Horton,Kara C Anderson,Kaitlin M Love et al.
William B Horton et al.
Aims/hypothesis: We aimed to evaluate whether prandial insulin timing affects vascular function in people with type 1 diabetes. Our hypothesis was that premeal insulin administration would lead to greater myocardial micro...