The diabetes-associated K+ channel TALK-2 controls human beta cell endoplasmic reticulum Ca2+ handling, which promotes basal insulin release and limits glucose-stimulated insulin secretion [0.03%]
糖尿病相关的钾通道TALK-2控制人类β细胞内质网Ca2+的处理，从而促进基础胰岛素释放并限制葡萄糖刺激的胰岛素分泌
Jordyn R Dobson,Prasanna K Dadi,Matthew T Dickerson et al.
Jordyn R Dobson et al.
Aims/hypothesis: The two-pore domain K+ channel TWIK1-related alkalinisation-activated K+ channel 2 (TALK-2) is encoded by KCNK17, which is one of the most abundant beta cell K+ channel transcripts that also shows high is...
Canagliflozin attenuates CMR-quantified myocardial fibrosis in individuals with type 2 diabetes mellitus at high cardiovascular risk: a randomised open-label controlled trial [0.03%]
卡格列净可减轻心血管疾病高危2型糖尿病患者的定量磁共振成像心肌纤维化：一项随机、开放标签的对照试验
Hongmei Yan,Jiaojiao Liu,Zhitian Zhang et al.
Hongmei Yan et al.
Aims/hypothesis: We aimed to investigate canagliflozin's effects on myocardial fibrosis, cardiac structure and function, and microcirculation in high-cardiovascular-risk type 2 diabetes mellitus through cardiac magnetic r...
Maternal pre-pregnancy BMI differentially regulates intracellular pH in human umbilical vein endothelium from gestational diabetes mellitus pregnancies, with alkalinisation-associated reduction of adenosine transport in normal weight pregnancies [0.03%]
母体孕前体重指数通过不同调节人脐静脉内皮细胞pH值来影响妊娠糖尿病，正常体重产妇表现出与细胞碱化相关的腺苷转运降低
Gonzalo Fuentes,Paola Valero,Marcelo Cornejo et al.
Gonzalo Fuentes et al.
Aims/hypothesis: Gestational diabetes mellitus (GDM) is associated with fetoplacental endothelial dysfunction, including impaired extracellular clearance of adenosine, a vasodilator, in HUVECs. This study investigated the...
Subtypes of newly diagnosed type 2 diabetes and risk of complications: analysis of electronic health records in the USA [0.03%]
美国电子健康记录中新诊断的2型糖尿病亚型与并发症风险的分析
Zhongyu Li,Star Liu,Joyce C Ho et al.
Zhongyu Li et al.
Aims/hypothesis: Data-driven subtyping of type 2 diabetes has not been translated into clinical practice due to the lack of routine fasting glucose and insulin measurements. We aimed to identify type 2 diabetes subtypes i...
Thromboxane signalling links immune activation to enhanced glucose uptake in skeletal muscle [0.03%]
血小板衍生四烷二醇信号通过免疫细胞活化促进骨骼肌葡萄糖摄取
Ahmed M Abdelmoez,Maxence Jollet,Xue Yu et al.
Ahmed M Abdelmoez et al.
Aims/hypothesis: Exercise elicits a spectrum of metabolic and inflammatory responses that are crucial for skeletal muscle adaptation and overall health, particularly in the context of metabolic diseases, yet the contribut...
Giuseppe Maltese,Janaka Karalliedde,Jugdeep Dhesi et al.
Giuseppe Maltese et al.
Over recent decades, the life expectancy of individuals with type 1 diabetes has steadily improved due to advances in therapies that enhance metabolic control alongside better prevention and management of complications. However, this extend...
Geospatial clustering of type 1 diabetes in Sweden: a cohort study based on all residential locations from birth to diagnosis [0.03%]
基于从出生到诊断的所有居住地位置的瑞典1型糖尿病地理空间聚类：队列研究
Samy Sebraoui,Oskar Englund,Fredrik Nyberg et al.
Samy Sebraoui et al.
Aims/hypothesis: Type 1 diabetes develops gradually, and previous exposures may influence incidence. We aimed to assess the geographical variation in type 1 diabetes incidence in Sweden by considering all residential loca...
Novel deuterium metabolic imaging technique reveals distinct patterns of postprandial hepatic glucose homeostasis in individuals with type 1 diabetes and healthy control individuals: a case-control study [0.03%]
新型氘代谢成像技术揭示1型糖尿病患者和健康受试者餐后肝脏葡萄糖稳态的差异：病例对照研究
Alessandro Brunasso,Naomi F Lange,Simone Poli et al.
Alessandro Brunasso et al.
Aims/hypothesis: Subcutaneous insulin delivery in individuals with insulin-deficient type 1 diabetes bypasses the portal circulation, disrupting the physiological porto-systemic insulin gradient and affecting postprandial...