Metabolic state determines the brain and direct islet effects of liraglutide on enhanced insulin secretion [0.03%]
代谢状态决定了利拉鲁肽对胰岛和大脑在增强胰岛素分泌的直接影响
Chiara Saponaro,Monica Imbernon,Isaline Louvet et al.
Chiara Saponaro et al.
Aims/hypothesis: Liraglutide, a glucagon-like peptide-1 receptor (GLP-1R) agonist for type 2 diabetes and obesity management, shows variable patient responses. We investigated the metabolic state-dependent mechanisms unde...
Autoantibody screening in children who are first-degree relatives of individuals with type 1 diabetes in a sibling-dominant cohort in Turkey: a multicentre study on prevalence, determinants and post-screening parent-child anxiety [0.03%]
土耳其兄弟姐妹为主的队列中1型糖尿病患者一级亲属儿童自身抗体筛查的多中心研究：患病率、决定因素及筛查后父母-子女焦虑状况
Uğur C Yılmaz,Deniz Ö Kızılay,Özlem K Kurt et al.
Uğur C Yılmaz et al.
Aims/objective: We screened 2-18-year-old first-degree relatives (FDRs) of individuals with type 1 diabetes in Turkey for diabetes-associated autoantibodies to define their prevalence and age distribution, to identify det...
Metabolic and vascular outcomes after transition to the MiniMed 780G system in adults ≥65 years with type 1 diabetes: a randomised, single-centre study [0.03%]
一项针对成人≥65岁1型糖尿病患者的随机单中心研究：切换到MiniMed 780G系统的代谢和血管结局
Bartłomiej Matejko,Katarzyna Cyranka,Paulina Suduł et al.
Bartłomiej Matejko et al.
Aims/hypothesis: Hybrid closed-loop insulin delivery systems are increasingly regarded as the preferred therapy for type 1 diabetes, although evidence in older adults remains limited. The aim of this randomised study was ...
Type IIB PKA serves as the primary effector of Gs-coupled receptor-potentiated insulin secretion in mice by orchestrating ion channels and granule phenotype [0.03%]
I型B PKA通过协调离子通道和颗粒表型在小鼠中作为Gs偶联受体增强胰岛素分泌的主要效应器
Ying Liu,Yunzhi Ni,Chuantong Xie et al.
Ying Liu et al.
Aims/hypothesis: G-protein-coupled receptors (GPCRs) play an important role in maintaining systemic glucose homeostasis by regulating insulin secretion, with protein kinase A (PKA) signalling serving as a key downstream e...
Impacting lives of people with diabetes: lessons learnt in India may be applicable to other low- and middle-income countries [0.03%]
印度糖尿病患者的治疗经验或可应用于其他中低收入国家
Viswanathan Mohan
Viswanathan Mohan
Delivering optimal care to people with diabetes in low- and middle-income countries (LMICs) such as India presents several challenges. The magnitude of the population affected by diabetes is considerable. Providing quality diabetes care to ...
Metabolic drivers of MASLD and MASH: from hormonal imbalance to fibrosis [0.03%]
MASLD和MASH的代谢驱动因素：从激素失衡到纤维化
Amalia Gastaldelli,Egeria Scoditti,Maria Paula Macedo
Amalia Gastaldelli
Metabolic dysfunction-associated steatotic liver disease (MASLD) and its more severe and aggressive form, metabolic dysfunction-associated steatohepatitis (MASH), represent liver-specific consequences of systemic metabolic dysfunction. This...
Somatostatin receptors shape insulin and glucagon output within the pancreatic islet in mice through direct and paracrine effects [0.03%]
生长抑素受体通过直接和旁分泌效应塑造小鼠胰岛中胰岛素和胰高血糖素的释放
Ryan G Hart,Jordan J Lee,Karen Zhai et al.
Ryan G Hart et al.
Aims/hypothesis: Pancreatic delta cells secrete somatostatin (SST), which can inhibit both alpha cells and beta cells of the pancreatic islet. By controlling insulin and glucagon release, delta cells play an important rol...
Gender differences in hypoglycaemia in type 1 and insulin-treated type 2 diabetes: the Hypo-METRICS study [0.03%]
Hypo-METRICS研究中的1型和接受胰岛素治疗的2型糖尿病患者的低血糖性别差异
Aisling McCarthy,Gráinne Kent,Jonah Thomas et al.
Aisling McCarthy et al.
Aims/hypothesis: The aim of this study was to explore associations between gender and hypoglycaemia experience among people with type 1 diabetes or insulin-treated type 2 diabetes in a free-living environment in the Hypo-...
Pharmacological inhibition of perforin dampens CD8+ T cell-mediated beta cell destruction in autoimmune diabetes in mice [0.03%]
药理学抑制穿孔素可减弱小鼠自身免疫糖尿病中CD8+t细胞介导的β细胞破坏作用
Prerak M Trivedi,Tara Catterall,Vivien R Sutton et al.
Prerak M Trivedi et al.
Aims/hypothesis: CD8⁺ T cells are key mediators of beta cell destruction in type 1 diabetes, employing the perforin/granzyme and Fas/Fas ligand pathways. Evidence from our studies and others indicates that perforin plays...