Nuclear fibroblast growth factor-2 interacts specifically with splicing factor SF3a66 [0.03%]
核纤维细胞生长因子-2特异地与剪接因子SF3a66相互作用
Susanne Gringel,Jeroen van Bergeijk,Kirsten Haastert et al.
Susanne Gringel et al.
Fibroblast growth factor 2 (FGF-2) has a dual role as a classical extracellular signaling protein and as an intracellular factor. Isoforms of FGF-2, resulting from alternatively used start codons on one mRNA species, locate differentially t...
St. John's wort (Hypericum perforatum) counteracts cytokine-induced tryptophan catabolism in vitro [0.03%]
圣约翰草（Hypericum perforatum）通过体外实验对抗细胞因子诱导的色氨酸分解代谢
Christiana Winkler,Barbara Wirleitner,Katharina Schroecksnadel et al.
Christiana Winkler et al.
St. John's wort (Hypericum perforatum) is an ancient folk remedy that has antiviral and antibacterial properties. Anti-inflammatory effects of the plant have been described and the application of H. perforatum extract as an effective antide...
Functional characterization of the postulated intramolecular sphingolipid activator protein domain of human acid sphingomyelinase [0.03%]
人酸性鞘磷脂酶分子内拟议的疏水激活蛋白结构域的功能表征
Melanie Kölzer,Klaus Ferlinz,Oliver Bartelsen et al.
Melanie Kölzer et al.
Degradation of membrane-bound sphingomyelin to phosphorylcholine and ceramide is catalyzed by the water-soluble lysosomal acid sphingomyelinase (A-SMase). The presence of sphingolipid activator proteins (Saps: saposins A-D; GM2 activator) i...
Novel thioredoxin targets in Dictyostelium discoideum identified by two-hybrid analysis: interactions of thioredoxin with elongation factor 1alpha and yeast alcohol dehydrogenase [0.03%]
关于Dictyostelium discoideum中新硫氧还蛋白靶标的鉴定：有关硫氧还蛋白与延伸因子1α及酵母酒精脱氢酶相互作用的报告
Thomas Brodegger,Anja Stockmann,Jürgen Oberstrass et al.
Thomas Brodegger et al.
Thioredoxins (Trx) are ubiquitous dicysteine proteins capable of modulating enzymes and other cellular targets through specific disulfide-dithiol redox changes. They are unique in that a large number of very diverse metabolic systems are ad...
M Angeles Gilabert,Lorena G Fenoll,Francisco García-Molina et al.
M Angeles Gilabert et al.
We report here on the stereospecificity observed in the action of horseradish peroxidase (HRPC) on monophenol and diphenol substrates. Several enantiomers of monophenols and o-diphenols were assayed: L-tyrosinol, D-tyrosinol, L-tyrosine, DL...
Replacement of the interchain disulfide bridge-forming amino acids A7 and B7 by glutamate impairs the structure and activity of insulin [0.03%]
天冬氨酸替代胰岛素分子中形成链间二硫键的氨基酸A7和B7后其结构与活性受损
Zhan-Yun Guo,Xiao-Yuan Jia,You-Min Feng
Zhan-Yun Guo
Insulin contains three disulfide bonds, one intrachain bond, A6-A11, and two interchain bonds, A7-B7 and A20-B19. Site-directed mutagenesis results (the two cysteine residues of disulfide A7-B7 were replaced by serine) showed that disulfide...
Conserved asparagine residue 54 of alpha-sarcin plays a role in protein stability and enzyme activity [0.03%]
保守的天冬酰胺残基54在蛋白稳定性及酶活性中起作用-alpha-肌凝蛋白的例子
Ansgar Siemer,Manuel Masip,Nelson Carreras et al.
Ansgar Siemer et al.
Asparagine 54 of alpha-sarcin is a conserved residue within the proteins of the ribotoxin family of microbial ribonucleases. It is located in loop 2 of the protein, which lacks repetitive secondary structure elements but exhibits a well-def...
Thermal unfolding of ribonuclease T1 studied by multi-dimensional NMR spectroscopy [0.03%]
二维核磁共振光谱研究热致核糖核酸酶T1的解折叠过程
Hisae Matsuura,Sakurako Shimotakahara,Chiseko Sakuma et al.
Hisae Matsuura et al.
Thermal unfolding of ribonculease (RNase) T1 was studied by 1H nuclear Overhauser enhancement spectroscopy (NOESY) and 1H- 15N heteronuclear single-quantum coherence (HSQC) NMR spectroscopy at various temperatures. Native RNase T1 is a sing...
Structural characterization of extracellular lipase from Streptomyces rimosus: assignment of disulfide bridge pattern by mass spectrometry [0.03%]
大规模培养中产朊假单胞菌对数生长期细胞的蛋白质组学分析：质谱法测定硫化桥模式对芽孢杆菌外源性脂肪酶结构特征的表征
Ivana Lescić,Martin Zehl,Roland Müller et al.
Ivana Lescić et al.
The cloning, sequencing and high-level expression of the gene encoding extracellular lipase from Streptomyces rimosus R6-554W have been recently described, and the primary structure of this gene product was deduced using a bioinformatic app...
Neuroendocrine regulation of salivary IgA synthesis and secretion: implications for oral health [0.03%]
神经内分泌调节的 saliva IgA 合成与分泌对口腔健康的意义
Wijnand Teeuw,Jos A Bosch,Enno C I Veerman et al.
Wijnand Teeuw et al.
Secretory immunoglobulin A (S-IgA) represents the main adaptive immune mechanism in the oral cavity. The regulation of secretion and synthesis of S-IgA is not only dependent on prior antigenic stimulation, but is also under strong neuroendo...