Varicella-zoster virus IE63 protein represses the basal transcription machinery by disorganizing the pre-initiation complex [0.03%]
IE63蛋白通过破坏转录起始复合物干扰单纯疱疹病毒基线转录
Emmanuel Di Valentin,Sébastien Bontems,Lionel Habran et al.
Emmanuel Di Valentin et al.
Using transient transfection assays, regulation properties of varicella-zoster virus (VZV)-encoded IE63 protein were analyzed on several VZV immediate early (ORF4), early (ORF28) and late (ORF67) promoters. IE63 was shown to repress the bas...
Self-organization versus Watchmaker: stochastic dynamics of cellular organization [0.03%]
自组织与机械构造：细胞结构的随机动态学
Alexei Kurakin
Alexei Kurakin
The cell, as a molecular system, is often interpreted in terms of complex clockworks, and the design charts of mechanical and electrical engineering are assumed to provide adequate approximations for the description of cellular organization...
On the mechanism of alkylphosphocholine (APC)-induced apoptosis in tumour cells [0.03%]
烷基磷胆碱(APC)诱导肿瘤细胞凋亡的作用机制研究
Carolin Oberle,Ulrich Massing,Harald F Krug
Carolin Oberle
Alkylphosphocholines (APCs) represent a new and very encouraging class of antitumour agents that have also been shown to induce apoptosis in tumour cells, but their exact mode of action has still not been elucidated. The APC compound presen...
TGF beta-induced focal complex formation in epithelial cells is mediated by activated ERK and JNK MAP kinases and is independent of Smad4 [0.03%]
TGF-β诱导的上皮细胞斑点复合物形成由活化的ERK和JNK丝裂原活化蛋白激酶介导，并且独立于Smad4
Yukiko Imamichi,Oliver Waidmann,Ramona Hein et al.
Yukiko Imamichi et al.
Advanced malignancies often exhibit increased concentrations of transforming growth factor-beta (TGF beta), which has been suggested to promote invasion and metastasis. While inhibition of epithelial cell proliferation in response to TGF be...
Doxorubicin induces EGF receptor-dependent downregulation of gap junctional intercellular communication in rat liver epithelial cells [0.03%]
多柔比星通过表皮生长因子受体诱导大鼠肝上皮细胞间连接通讯下调
Kotb Abdelmohsen,Claudia von Montfort,Dominik Stuhlmann et al.
Kotb Abdelmohsen et al.
Exposure of rat liver epithelial cells to doxorubicin, an anthraquinone derivative widely employed in cancer chemotherapy, led to a dose-dependent decrease in gap junctional intercellular communication (GJC). Gap junctions are clusters of i...
Phosphoinositide 3-kinase signaling in the cellular response to oxidative stress [0.03%]
磷脂激酶在细胞氧化应激反应中的作用
Andreas Barthel,Lars-Oliver Klotz
Andreas Barthel
Oxidative stress is linked to the pathogenesis and pathobiochemistry of various diseases, including cancer, diabetes and cardiovascular disorders. The non-specific damaging effect of reactive oxygen species (ROS) generated during oxidative ...
Klaudia Giehl
Klaudia Giehl
The ras genes give rise to a family of related GTP-binding proteins that exhibit potent transforming potential. Mutational activation of Ras proteins promotes oncogenesis by disturbing a multitude of cellular processes, such as gene express...
Interfering with hepatitis C virus IRES activity using RNA molecules identified by a novel in vitro selection method [0.03%]
一种新的体外选择方法识别干扰丙型肝炎病毒IRES活性的RNA分子
Cristina Romero-López,Alicia Barroso-delJesus,Elena Puerta-Fernández et al.
Cristina Romero-López et al.
Hepatitis C virus (HCV) infection is one of the world's major health problems, and the identification of efficient HCV inhibitors is a major goal. Here we report the isolation of efficient anti-HCV internal ribosome entry site (IRES) RNA mo...
Purification and characterisation of blarinasin, a new tissue kallikrein-like protease from the short-tailed shrew Blarina brevicauda: comparative studies with blarina toxin [0.03%]
来自短尾鼩Blarina brevicauda的新型组织胰蛋白酶样丝氨酸蛋白酶blarinasin的纯化和鉴定：与blarina毒素比较研究
Masaki Kita,Yuushi Okumura,Satoshi D Ohdachi et al.
Masaki Kita et al.
A new tissue kallikrein-like protease, blarinasin, has been purified from the salivary glands of the short-tailed shrew Blarina brevicauda. Blarinasin is a 32-kDa N-glycosylated protease with isoelectric values ranging between 5.3 and 5.7, ...
Comparative Study
Biological chemistry. 2005 Feb;386(2):177-82. DOI:10.1515/BC.2005.022 2005
Morphology and transfection study of human microvascular endothelial cell angiogenesis: an in vitro three-dimensional model [0.03%]
人微血管内皮细胞体外三维球状模型的形态学及转染研究
Jasmin Lienau,Cortina Kaletta,Michael Teifel et al.
Jasmin Lienau et al.
Microvascular endothelial cells from human neonatal foreskin were grown in vitro until a three-dimensional network of capillary-like structures was formed. All stages of the angiogenic cascade could be observed in this in vitro model, inclu...