Bing Shen,Samir S El-Dahr
Bing Shen
The renin-angiotensin (RAS) and kallikrein-kinin (KKS) systems play a key role in multiple physiological and pathophysiological conditions, including growth and development, inflammation, blood pressure regulation and control of renal funct...
The kinin system mediates hyperalgesia through the inducible bradykinin B1 receptor subtype: evidence in various experimental animal models of type 1 and type 2 diabetic neuropathy [0.03%]
激肽系统通过诱导型缓激肽B1受体亚型介导痛觉过敏：1型和2型糖尿病神经病的多种实验动物模型中的证据
Bichoy H Gabra,Nathalie Berthiaume,Pierre Sirois et al.
Bichoy H Gabra et al.
Both insulin-dependent (type 1) and insulin-independent (type 2) diabetes are complex disorders characterized by symptomatic glucose intolerance due to either defective insulin secretion, insulin action or both. Unchecked hyperglycemia lead...
João B Pesquero,Michael Bader
João B Pesquero
Transgenic and gene-targeting technologies allowing the generation of genetically altered animal models have greatly advanced our understanding of the function of specific genes. This is also true for the kallikrein-kinin system (KKS), in w...
L M Fredrik Leeb-Lundberg
L M Fredrik Leeb-Lundberg
Inhibitory plant serpins with a sequence of three glutamine residues in the reactive center [0.03%]
含三个谷氨酰胺残基反应中心的抑制植物丝氨酸蛋白酶抑制剂
Jørn Hejgaard
Jørn Hejgaard
Serpins appear to be ubiquitous in eukaryotes, except fungi, and are also present in some bacteria, archaea and viruses. Inhibitory serpins with a glutamine as the reactive-center P1 residue have been identified exclusively in a few plant s...
Structural properties of substrate proteins determine their proteolysis by the mitochondrial AAA+ protease Pim1 [0.03%]
基质底物蛋白的结构特性决定其被线粒体AAA+蛋白酶Pim1降解的性质
Birgit von Janowsky,Karin Knapp,Tamara Major et al.
Birgit von Janowsky et al.
The protease Pim1/LON, a member of the AAA+ family of homo-oligomeric ATP-dependent proteases, is responsible for the degradation of soluble proteins in the mitochondrial matrix. To establish the molecular parameters required for the specif...
Trypsin inhibition by macrocyclic and open-chain variants of the squash inhibitor MCoTI-II [0.03%]
cucurbita moschata 半胱氨酸蛋白酶抑制剂Mcoti-i的环化变异体及其开链前体对胰凝乳蛋白酶的抑制作用
Olga Avrutina,Hans-Ulrich Schmoldt,Dusica Gabrijelcic-Geiger et al.
Olga Avrutina et al.
MCoTI-I and MCoTI-II from the seeds of Momordica cochinchinensis are inhibitors of trypsin-like proteases and the only known members of the large family of squash inhibitors that are cyclic and contain an additional loop connecting the amin...
Linear three-iron centres are unlikely cluster degradation intermediates during unfolding of iron-sulfur proteins [0.03%]
铁硫蛋白解折叠过程中线性三铁中心不可能是聚集退化中间体
Sónia S Leal,Cláudio M Gomes
Sónia S Leal
Recent studies on the chemical alkaline degradation of ferredoxins have contributed to the hypothesis that linear three-iron centres are commonly observed as degradation intermediates of iron-sulfur clusters. In this work we assess the vali...
Comparative Study
Biological chemistry. 2005 Dec;386(12):1295-300. DOI:10.1515/BC.2005.147 2005
Gayatri Gowrishankar,Reinhard Winzen,Frank Bollig et al.
Gayatri Gowrishankar et al.
Post-transcriptional mechanisms contribute to the changes in gene expression induced by cell stress. The effect of UV-B light on mRNA degradation in HeLa cells was investigated using a transcriptional chase system to determine the decay kin...
Torsten Waldminghaus,Anja Fippinger,Juliane Alfsmann et al.
Torsten Waldminghaus et al.
Expression of many rhizobial small heat-shock genes is controlled by the ROSE element, a thermoresponsive structure in the 5'-untranslated region of the corresponding mRNAs. Using a bioinformatics approach, we found more than 20 new potenti...