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Trypsin inhibition by macrocyclic and open-chain variants of the squash inhibitor MCoTI-II

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MCoTI-I and MCoTI-II from the seeds of Momordica cochinchinensis are inhibitors of trypsin-like proteases and the only known members of the large family of squash inhibitors that are cyclic and contain an additional loop connecting the amino- and the carboxy-t... ...