Modulation of autocrine TNF-alpha-stimulated matrix metalloproteinase 9 (MMP-9) expression by mitogen-activated protein kinases in THP-1 monocytic cells [0.03%]
MAPKs调节自分泌TNF-α刺激的单核细胞系THP-1中基质金属蛋白酶9(MMP-9)的表达
Michael Heidinger,Helmut Kolb,Hans-Willi Krell et al.
Michael Heidinger et al.
Matrix metalloproteinase 9 (MMP-9) is implicated in various physiological processes by its ability to degrade the extracellular matrix (ECM) and process multiple regulatory proteins. Normally, MMP-9 expression is tightly controlled in cells...
Dual signal transduction mediated by a single type of olfactory receptor expressed in a heterologous system [0.03%]
一种嗅觉受体在异源表达系统中介导双信号转导路径
Hwi Jin Ko,Tai Hyun Park
Hwi Jin Ko
Controversy exists over the relationship between the cAMP and IP3 pathways in vertebrate olfactory signal transduction, as this process is known to occur by either of the two pathways. Recent studies have shown that a single olfactory neuro...
Ecto- and cytosolic 5'-nucleotidases in normal and AMP deaminase-deficient human skeletal muscle [0.03%]
正常和AMP脱氨酶缺陷的成人及儿童人体骨骼肌细胞质和胞外5'-核苷酸酶
Frank Hanisch,Ylva Hellsten,Stephan Zierz
Frank Hanisch
In skeletal muscle, adenosine monophosphate (AMP) is mainly deaminated by AMP deaminase. However, the C34T mutation in the AMPD1 gene severely reduces AMP deaminase activity. Alternatively, intracellular AMP is dephosphorylated to adenosine...
Vitamin B1 de novo synthesis in the human malaria parasite Plasmodium falciparum depends on external provision of 4-amino-5-hydroxymethyl-2-methylpyrimidine [0.03%]
人疟原虫伯氨醇从头合成依赖于体外提供的4-氨基-5-羟甲基-2-甲基嘧啶
Carsten Wrenger,Marie-Luise Eschbach,Ingrid B Müller et al.
Carsten Wrenger et al.
Vitamin B1 (thiamine) is an essential cofactor for several key enzymes of carbohydrate metabolism. Mammals have to salvage this crucial nutrient from their diet to complement their deficiency of de novo synthesis. In contrast, bacteria, fun...
Interaction of the BELL-like protein ATH1 with DNA: role of homeodomain residue 54 in specifying the different binding properties of BELL and KNOX proteins [0.03%]
BELL-homeodmain蛋白ATH1与DNA的相互作用以及homeodmain第54位氨基酸在决定BELL和KNOX两类同源异型蛋白质结合特性上的不同作用
Ivana L Viola,Daniel H Gonzalez
Ivana L Viola
We have studied the interaction of the BELL-like Arabidopsis homeodomain protein ATH1 with DNA. Analysis of oligonucleotides selected by the ATH1 homeodomain from a random mixture suggests that ATH1 preferentially binds the sequence TGACAGG...
Solvent-induced changes in photochemical activity and conformation of photosystem I particles by glycerol [0.03%]
甘油介导的光系统I颗粒的光化学活性和构象变化
Xiaohua Ren,Zhenle Yang,Tingyun Kuang
Xiaohua Ren
It has been shown that a large number of water molecules coordinate with the pigments and subunits of photosystem I (PSI); however, the function of these water molecules remains to be clarified. In this study, the photosynthetic properties ...
Renal gene expression profiling using kinin B1 and B2 receptor knockout mice reveals comparable modulation of functionally related genes [0.03%]
利用激肽B1和B2受体基因敲除小鼠进行肾脏基因表达谱分析发现功能相关基因的相同调节模式
Dimcho Bachvarov,Magdalena Bachvarova,Rainelli Koumangaye et al.
Dimcho Bachvarov et al.
The kinin B2 receptor, which is constitutively expressed in a large number of tissues, mediates most of the known effects of bradykinin (BK). Normally undetectable in healthy tissues, the B1 receptor is strongly over-expressed under patholo...
Comparative Study
Biological chemistry. 2006 Jan;387(1):15-22. DOI:10.1515/BC.2006.004 2006
Haibin Wang,Corina Ehnert,Gary J Brenner et al.
Haibin Wang et al.
Pain hypersensitivity after tissue injury and inflammation is contributed to by a reduction in the threshold and an increase in the responsiveness of the peripheral terminals of high-threshold nociceptor neurons, the phenomenon of periphera...
Cor de Wit,Bernd Hoepfl,Stephanie E Wölfle
Cor de Wit
Cellular interaction in vessels is achieved by multiple communication pathways, including gap junctions (GJs). They provide intercellular channels, allowing direct interaction of endothelial and smooth muscle cells and the coordination of c...
Cathepsin B localizes to plasma membrane caveolae of differentiating myoblasts and is secreted in an active form at physiological pH [0.03%]
猫肉毒素B定位于分化肌母细胞的质膜小区结构并以活性形式在生理pH值条件下被分泌出去
Derek T Jane,Les Morvay,Luis Dasilva et al.
Derek T Jane et al.
Our in vitro studies support a functional link between the induction of cathepsin B gene expression and the catabolic restructuring associated with myotube formation during myogenesis in vivo. We have tested two predictions that are basic t...