Identification of candidate substrates for ectodomain shedding by the metalloprotease-disintegrin ADAM8 [0.03%]
ADAM8金属蛋白酶-散在素的跨膜区底物识别及蛋白水解切除作用的研究
Silvia Naus,Simone Reipschläger,Dirk Wildeboer et al.
Silvia Naus et al.
ADAM proteases are type I transmembrane proteins with extracellular metalloprotease domains. As for most ADAM family members, ADAM8 (CD156a, MS2) is involved in ectodomain shedding of membrane proteins and is linked to inflammation and neur...
Identification of calpain cleavage sites in the G1 cyclin-dependent kinase inhibitor p19(INK4d) [0.03%]
凋亡calpain切割G1周期D型 cyclin依赖性蛋白激酶抑制因子p19(INK4d)的位点鉴定
Joma Joy,Narasimharao Nalabothula,Madhumita Ghosh et al.
Joma Joy et al.
Calpains are a large family of Ca2+-dependent cysteine proteases that are ubiquitously distributed across most cell types and vertebrate species. Calpains play a role in cell differentiation, apoptosis, cytoskeletal remodeling, signal trans...
Inhibition of mRNA deadenylation and degradation by different types of cell stress [0.03%]
不同类型细胞压力对抑制 mRNA 去多聚腺苷酸化及降解的影响
Gayatri Gowrishankar,Reinhard Winzen,Oliver Dittrich-Breiholz et al.
Gayatri Gowrishankar et al.
We have previously observed rapid and strong inhibition of mRNA deadenylation and degradation in response to UV-B light [Gowrishankar et al., Biol. Chem. 386 (2005), pp. 1287-1293]. Expression analysis using a microarray for inflammatory ge...
Sachiko Iwaki-Egawa,Takaya Yamamoto,Yasuhiro Watanabe
Sachiko Iwaki-Egawa
Adenosine deaminase (ADA) plays an important role in the immune system, and its activity is composed of two kinetically distinct isozymes, ADA1 and ADA2. ADA2 is a major component of human plasma total ADA activity and ADA2 activity is sign...
p190-RhoGAP as an integral component of the Tiam1/Rac1-induced downregulation of Rho [0.03%]
Tiam1/Rac1诱导的Rho下调的组成成分p190-RhoGAP
Ulrike Herbrand,Mohammad Reza Ahmadian
Ulrike Herbrand
The Rho family of small GTPases plays a central role in intracellular signal transduction, particularly in reorganization of the actin cytoskeleton. Rho activity induces cell contractility, whereas Rac promotes cellular protrusion, which co...
Endotoxin-like properties of a rhamnolipid exotoxin from Burkholderia (Pseudomonas) plantarii: immune cell stimulation and biophysical characterization [0.03%]
植物致病性伯克霍尔德菌（荧光假单胞杆菌）产生的类内毒素型糖脂外毒素的免疫学和物理化学性质研究
Jörg Andrä,Jörg Rademann,Jörg Howe et al.
Jörg Andrä et al.
Here we report on the purification, structural characterization, and biological activity of a glycolipid, 2-O-alpha-L-rhamnopyranosyl-alpha-L-rhamnopyranosyl-alpha(R)-3-hydroxytetradecanoyl-(R)-3-hydroxytetradecanoate (RL-2,2(14)) produced ...
Truncated PrP(c) in mammalian brain: interspecies variation and location in membrane rafts [0.03%]
哺乳动物脑中的截短型PrP(c):物种差异和细胞膜筏定位
Isabelle Laffont-Proust,Raymonde Hässig,Stéphane Haïk et al.
Isabelle Laffont-Proust et al.
A key molecular event in prion diseases is the conversion of cellular prion protein (PrP(c)) into an abnormal misfolded conformer (PrP(sc)). The PrP(c) N-terminal domain plays a central role in PrP(c) functions and in prion propagation. Bec...
Pressure- and temperature-induced unfolding studies: thermodynamics of core hydrophobicity and packing of ribonuclease A [0.03%]
压力和温度引起展平研究：核糖核酸酶A核心水胶性以及紧密度的热动力学
Josep Font,Antoni Benito,Joan Torrent et al.
Josep Font et al.
In this work we demonstrate that heat and pressure induce only slightly different energetic changes in the unfolded state of RNase A. Using pressure and temperature as denaturants on a significant number of variants, and by determining the ...
The zinc finger protein ZNF297B interacts with BDP1, a subunit of TFIIIB [0.03%]
锌指蛋白ZNF297B与TFIIIB亚基BDP1相互作用
Frank Schoenen,Brunhilde Wirth
Frank Schoenen
The human gene BDP1, localized on chromosome 5q13 in close proximity to the spinal muscular atrophy determining gene SMN, encodes a large protein consisting of 2254 amino acids (aa). In the first third of the gene, the subunit of the RNA po...