p190-RhoGAP as an integral component of the Tiam1/Rac1-induced downregulation of Rho
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The Rho family of small GTPases plays a central role in intracellular signal transduction, particularly in reorganization of the actin cytoskeleton. Rho activity induces cell contractility, whereas Rac promotes cellular protrusion, which counteracts Rho signal... ...