Functional studies of the small subunit of EcoHK31I DNA methyltransferase [0.03%]
EcoHK31I DNA甲基转移酶的小亚基的功能研究
Wai-To Fung,Kong-Hung Sze,Kai-Fai Lee et al.
Wai-To Fung et al.
EcoHK31I DNA methyltransferase recognizes the sequence 5'-YGGCCR-3' and adds a methyl group to the fifth position of the internal cytosine to protect the DNA from cleavage by its cognate endonuclease. M.EcoHK31I is composed of polypeptides ...
Nitrite, a naturally occurring precursor of nitric oxide that acts like a 'prodrug' [0.03%]
亚硝酸盐是一种像“前药”一样起作用的NO天然前体分子
Christoph V Suschek,Tankred Schewe,Helmut Sies et al.
Christoph V Suschek et al.
There are enzymatic and non-enzymatic mechanisms that generate NO* from nitrite in blood, stomach, saliva, urine and skin. In blood vessels, nitrite-derived NO* can provide protection via compensatory vasodilation during hypoxia, and in var...
R John Ellis,Allen P Minton
R John Ellis
The generic tendency of proteins to aggregate into non-functional, and sometimes cytotoxic, structures poses a universal problem for all types of cell. This tendency is greatly exacerbated by the high total concentration of macromolecules f...
A fluorescence assay for rapid detection of ligand binding affinity to HIV-1 gp41 [0.03%]
一种快速检测HIV-1gp41与配体结合亲和力的荧光分析法
Miriam Gochin,Ryan Savage,Spencer Hinckley et al.
Miriam Gochin et al.
The fusion-active conformation of the envelope protein gp41 of HIV-1 consists of an N-terminal trimeric alpha-helical coiled-coil domain and three anti-parallel C-terminal helices that fold down the grooves of the coiled-coil to form a six-...
Identification of trypsin I as a candidate for influenza A virus and Sendai virus envelope glycoprotein processing protease in rat brain [0.03%]
大鼠脑中的病毒糖蛋白加工酶系试氨肽酶I的鉴定研究流感病毒和仙台病毒衣壳蛋白质体加工酶系统中候选酶为试氨酶I
Trong Quang Le,Miki Kawachi,Hiroshi Yamada et al.
Trong Quang Le et al.
Extracellular cleavage of virus envelope fusion glycoprotein hemagglutinin (HA0) by host trypsin-like proteases is a prerequisite for the infectivity and pathogenicity of human influenza A viruses and Sendai virus. The common epidemic influ...
Novel ketomethylene inhibitors of angiotensin I-converting enzyme (ACE): inhibition and molecular modelling [0.03%]
新型酮亚甲基血管紧张素转换酶(ACE)抑制剂： 抑制和分子模擬研究
Pierre Redelinghuys,Aloysius T Nchinda,Kelly Chibale et al.
Pierre Redelinghuys et al.
Inhibition of angiotensin I-converting enzyme (ACE) has become an effective strategy in the treatment of hypertension and cardiovascular disease. Keto-ACE, a previously described C-domain selective ACE inhibitor, was used as the basis for t...
Monomeric and dimeric GDF-5 show equal type I receptor binding and oligomerization capability and have the same biological activity [0.03%]
单体GDF-5和二聚体GDF-5具有相同的I型受体结合能力、寡聚化能力和生物学活性
Christina Sieber,Frank Plöger,Raphaela Schwappacher et al.
Christina Sieber et al.
Growth and differentiation factor 5 (GDF-5) is a homodimeric protein stabilized by a single disulfide bridge between cysteine 465 in the respective monomers, as well as by three intramolecular cysteine bridges within each subunit. A mature ...
Comparative Study
Biological chemistry. 2006 Apr;387(4):451-60. DOI:10.1515/BC.2006.060 2006
Birgitte B Olsen,Jørgen Petersen,Olaf-Georg Issinger
Birgitte B Olsen
Recombinant murine BID protein was used as an in vitro substrate for the CK2 holoenzyme and the catalytic CK2alpha subunit. The results obtained show that BID can only serve as a substrate for the catalytic CK2alpha subunit. Phosphorylation...
Comparative proteomic analysis of neoplastic and non-neoplastic germ cell tissue [0.03%]
癌性和非癌性生殖细胞组织的比较蛋白质组分析
Uwe Zimmermann,Heike Junker,Fabian Krämer et al.
Uwe Zimmermann et al.
A comparative proteomic analysis of neoplastic versus non-neoplastic seminoma identified glutathione S-transferase M3 as a differentially expressed protein. This expression difference could also be observed at the mRNA level, implying neopl...
Comparative Study
Biological chemistry. 2006 Apr;387(4):437-40. DOI:10.1515/BC.2006.058 2006
Role of the kinin B1 receptor in insulin homeostasis and pancreatic islet function [0.03%]
胰岛素稳态和胰腺细胞功能的激肽B1受体的作用
Ronaldo C Araújo,Marcelo A Mori,Vanessa F Merino et al.
Ronaldo C Araújo et al.
Kinins are potent vasoactive peptides generated in blood and tissues by the kallikrein serine proteases. Two distinct kinin receptors have been described, one constitutive (subtype B2) and one inducible (subtype B1), and many physiological ...