A fluorescence assay for rapid detection of ligand binding affinity to HIV-1 gp41
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The fusion-active conformation of the envelope protein gp41 of HIV-1 consists of an N-terminal trimeric alpha-helical coiled-coil domain and three anti-parallel C-terminal helices that fold down the grooves of the coiled-coil to form a six-helix bundle. Disrup... ...
