Transcription factor FOXM1c is repressed by RB and activated by cyclin D1/Cdk4 [0.03%]
转录因子FOXM1c受RB的抑制并由 Cyclin D1/Cdk4激活
Inken Wierstra,Jürgen Alves
Inken Wierstra
The proliferation-stimulating transactivator FOXM1c (MPP2) is repressed by RB and activated by cyclin D1/Cdk4 and therefore behaves like E2F. Despite its strong transactivation domain, FOXM1c is kept almost inactive by two different inhibit...
A stable analogue of glucose-dependent insulinotropic polypeptide, GIP(LysPAL16), enhances functional differentiation of mouse embryonic stem cells into cells expressing islet-specific genes and hormones [0.03%]
一种稳定的葡萄糖依赖性胰岛素多肽GIP(LysPAL16)可增强小鼠胚胎干细胞向表达特定胰腺内分泌细胞基因和激素的细胞分化功能
Lamin Marenah,Jane T McCluskey,Yasser H A Abdel-Wahab et al.
Lamin Marenah et al.
Embryonic stem (ES) cells can be differentiated into insulin-producing cells by conditioning the culture media. However, the number of insulin-expressing cells and amount of insulin released is very low. Glucose-dependent insulinotropic pol...
Modeling the 3D structure of wheat subtilisin/chymotrypsin inhibitor (WSCI). Probing the reactive site with two susceptible proteinases by time-course analysis and molecular dynamics simulations [0.03%]
小麦丝裂素/胰蛋白酶抑制剂(WSCI)的三维结构建模及反应位点的时序分析和分子动力学模拟
Angelo M Facchiano,Susan Costantini,Antimo Di Maro et al.
Angelo M Facchiano et al.
Comparative modeling and time-course hydrolysis experiments have been applied to investigate two enzyme-inhibitor complexes formed between the wheat subtilisin-chymotrypsin inhibitor (WSCI) and two susceptible proteinases. WSCI represents t...
Analysis of aldosterone-induced differential receptor-independent protein patterns using 2D-electrophoresis and mass spectrometry [0.03%]
采用二维电泳和质谱分析醛固酮诱导的不同的受体非依赖性蛋白模式
Susanne Böhmer,Christine Carapito,Britta Wilzewski et al.
Susanne Böhmer et al.
In the human body the mineralocorticoid aldosterone is responsible for maintaining water and electrolyte homeostasis and therefore controlling blood pressure. In addition, aldosterone has recently been associated with severe heart failure. ...
Interaction of a novel form of Pseudomonas aeruginosa alkaline protease (aeruginolysin) with interleukin-6 and interleukin-8 [0.03%]
铜绿假单胞菌碱性蛋白酶(aeruginolysin)与白细胞介素-6和白细胞介素-8的相互作用
Nancy R Matheson,Jan Potempa,James Travis
Nancy R Matheson
Pseudomonas aeruginosa secretes several proteases considered as important virulence factors. In this report we present data indicating that two key proinflammatory cytokines, interleukin-6 (IL-6) and IL-8, are substrates for pseudolysin (el...
Increased local levels of granulocyte colony-stimulating factor are associated with the beneficial effect of pre-elafin (SKALP/trappin-2/WAP3) in experimental emphysema [0.03%]
粒细胞集落刺激因子局部水平的提高与小鼠肺气肿模型中pre-elafin(SKALP/trappin-2/WAP3)的保护作用有关联性
Marie France Janelle,Alain Doucet,Dominique Bouchard et al.
Marie France Janelle et al.
Few therapeutic options are offered to treat inflammation and alveolar wall destruction in emphysema. The effect of recombinant human pre-elafin, an elastase inhibitor, was evaluated in porcine pancreatic elastase (PPE)-induced emphysema in...
Helicobacter pylori-induced downregulation of the secretory leukocyte protease inhibitor (SLPI) in gastric epithelial cell lines and its functional relevance for H. pylori-mediated diseases [0.03%]
Helicobacter pylori介导的胃上皮细胞系中分泌型白细胞弹力蛋白酶抑制剂(SLPI)下调及其对Helicobacter pylori相关疾病的功能影响
Thomas Wex,Gerhard Treiber,Marino Venerito et al.
Thomas Wex et al.
The secretory leukocyte protease inhibitor (SLPI) exerts antiproteolytic activity towards serine proteases, as well as anti-microbial and anti-inflammatory effects. To investigate its role in H. pylori-mediated diseases, SLPI expression was...
Human cathepsin L rescues the neurodegeneration and lethality in cathepsin B/L double-deficient mice [0.03%]
人源Cathepsin L可补救Cathepsin B/L双缺失小鼠的神经退行性病变及致死现象
Lisa Sevenich,Len A Pennacchio,Christoph Peters et al.
Lisa Sevenich et al.
Cathepsin B (CTSB) and cathepsin L (CTSL) are two widely expressed cysteine proteases thought to predominantly reside within lysosomes. Functional analysis of CTSL in humans is complicated by the existence of two CTSL-like homologs (CTSL an...
Kevin Martens,Rita Derua,Sandra Meulemans et al.
Kevin Martens et al.
The prolyl endopeptidase-like protein PREPL has recently attracted attention because its gene is located within two contiguous gene-deletion syndromes, the 2p21 deletion syndrome and the hypotonia-cystinuria syndrome. Deletion of the gene r...
The proprotein convertases and their implication in sterol and/or lipid metabolism [0.03%]
蛋白质转化酶与sterol和/或脂质代谢的关系
Nabil G Seidah,Abdel Majid Khatib,Annik Prat
Nabil G Seidah
The proprotein convertases represent a family of nine proteinases, comprising seven basic amino acid-specific subtilisin-like serine proteinases related to yeast kexin, known as PC1/3, PC2, furin, PC4, PC5/6, PACE4 and PC7, and two other su...