Paired helical filaments contain small amounts of cholesterol, phosphatidylcholine and sphingolipids [0.03%]
配对螺旋丝素含有少量的胆固醇、磷脂酰胆碱和鞘脂类物质
Gerald P Gellermann,Thomas R Appel,Peter Davies et al.
Gerald P Gellermann et al.
By using qualitative and quantitative high-performance thin layer chromatography (hpTLC) we found lipids associated with purified Alzheimer's (AD) paired helical filaments (PHF) in an amount of 1.4+/-0.2% of the total anhydrous mass. Compar...
Sequence determination of lychnin, a type 1 ribosome-inactivating protein from Lychnis chalcedonica seeds [0.03%]
长春花科紫云英种子中核糖体失活蛋白Lychnin的序列测定
Angela Chambery,Anna de Donato,Andrea Bolognesi et al.
Angela Chambery et al.
The complete amino acid sequence of lychnin, a type 1 ribosome-inactivating protein (RIP) isolated from Lychnis chalcedonica seeds, has been determined by automated Edman degradation and ESI-QTOF mass spectrometry. Lychnin consists of 234 a...
The solution structure of the membrane-proximal cytokine receptor domain of the human interleukin-6 receptor [0.03%]
人类白细胞介素6受体靠近膜区的细胞因子受体结构域的溶液结构
Oliver Hecht,Andrew J Dingley,Andreas Schwanter et al.
Oliver Hecht et al.
The members of the interleukin-6-type family of cytokines interact with receptors that have a modular structure and are built of several immunoglobulin-like and fibronectin type III-like domains. These receptors have a characteristic cytoki...
Structure-based specificity mapping of secreted aspartic proteases of Candida parapsilosis, Candida albicans, and Candida tropicalis using peptidomimetic inhibitors and homology modeling [0.03%]
基于结构的白色念珠菌、近平滑念珠菌和热带念珠菌分泌天冬氨酸蛋白酶特异性映射（采用肽类似物抑制剂及同源建模）
Filip Majer,Libuse Pavlícková,Pavel Majer et al.
Filip Majer et al.
Secreted aspartic proteases (Saps) of pathogenic Candida spp. represent a specific target for antifungal drug development. We synthesized a series of peptidomimetic inhibitors with different isosteric groups and modifications at individual ...
The K+ channel gene, Kcnb1: genomic structure and characterization of its 5'-regulatory region as part of an overlapping gene group [0.03%]
钾通道基因Kcnb1：基因组结构及其5'调控区作为重叠基因组的一部分的特征分析
Karim Roder,Gideon Koren
Karim Roder
Kcnb1 expression is down-regulated in certain types of cardiomyopathy. As a first step towards understanding Kcnb1 regulation, we determined its genomic structure and characterized its 5'-regulatory region. Two species of Kcnb1 mRNA were fo...
Thomas Mrowiec,Blanche Schwappach
Thomas Mrowiec
14-3-3 proteins affect the cell surface expression of several unrelated cargo membrane proteins, e.g., MHC II invariant chain, the two-pore potassium channels KCNK3 and KCNK9, and a number of different reporter proteins exposing Arg-based e...
Transcriptional signatures of immune cells in aryl hydrocarbon receptor (AHR)-proficient and AHR-deficient mice [0.03%]
芳烃受体(Ahr)功能正常的和不具备功能的实验小鼠免疫细胞转录特征分析
Markus Frericks,Vladimir V Temchura,Marc Majora et al.
Markus Frericks et al.
The ligand-activated aryl hydrocarbon receptor (AHR) is known to modulate many genes in a highly cell-specific manner, either directly or indirectly via secondary effects. In contrast, little is known about the effects of AHR deficiency on ...
Identifying target genes of the aryl hydrocarbon receptor nuclear translocator (Arnt) using DNA microarray analysis [0.03%]
采用DNA微阵列分析技术鉴定芳香烃受体核转位子（ARNT）的靶基因
Feng Wang,Shengli Shi,Ruixue Zhang et al.
Feng Wang et al.
The aryl hydrocarbon receptor nuclear translocator (Arnt) is a basic helix-loop-helix (bHLH) protein that also contains a Per-Arnt-Sim (PAS) domain. In addition to forming heterodimers with many other bHLH-PAS proteins, including the aryl h...
Aryl hydrocarbon receptor agonists directly activate estrogen receptor alpha in MCF-7 breast cancer cells [0.03%]
芳烃受体激动剂可直接激活MCF-7乳腺癌细胞中的雌激素受体α
Shengxi Liu,Maen Abdelrahim,Shaheen Khan et al.
Shengxi Liu et al.
The aryl hydrocarbon receptor (AhR) binds with high affinity to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) and related halogenated aromatics, but also binds with lower affinity to structurally diverse exogenous and endogenous chemicals. One...
Impact of the arylhydrocarbon receptor on eugenol- and isoeugenol-induced cell cycle arrest in human immortalized keratinocytes (HaCaT) [0.03%]
石菖蒲化学成分吴茱萸烯和异吴茱萸烯通过芳烃受体介导人永生角质细胞增殖抑制的作用机制研究
Michaela Kalmes,Andrea Neumeyer,Paola Rio et al.
Michaela Kalmes et al.
Fragrances such as eugenol (4-allyl-2-methoxyphenol) and isoeugenol (2-methoxy-4-propenylphenol), naturally found in reasonable quantities in the essential oils of different spices, are not only common causes of contact dermatitis but also ...