The staphostatin family of cysteine protease inhibitors in the genus Staphylococcus as an example of parallel evolution of protease and inhibitor specificity [0.03%]
以链球菌中半胱氨酸蛋白酶抑制剂家族为例探讨蛋白酶和抑制剂特异性的平行进化现象
Grzegorz Dubin,Benedykt Wladyka,Justyna Stec-Niemczyk et al.
Grzegorz Dubin et al.
Staphostatins constitute a family of staphylococcal cysteine protease inhibitors sharing a lipocalin-like fold and a unique mechanism of action. Each of these cytoplasmic proteins is co-expressed from one operon, together with a correspondi...
Metabolic effects of sub-chronic ablation of the incretin receptors by daily administration of (Pro3)GIP and exendin(9-39)amide in obese diabetic (ob/ob) mice [0.03%]
每天给药(PRO3)GIP和Exendin(9-39)胺对肥胖糖尿病(ob/ob)小鼠的肠降糖激素受体亚慢性消融及其代谢效应的影响
Jeremy C Parker,Nigel Irwin,Kerry S Lavery et al.
Jeremy C Parker et al.
Effects of chemical ablation of the GIP and GLP-1 receptors on metabolic aspects of obesity-diabetes were investigated using the stable receptor antagonists (Pro3)GIP and exendin(9-39)amide. Ob/ob mice received a daily i.p. injection of sal...
Resveratrol modulates mRNA transcripts of genes related to redox metabolism and cell proliferation in non-small-cell lung carcinoma cells [0.03%]
白藜芦醇通过调节非小细胞肺癌中抗氧化代谢及细胞增殖相关基因的mRNA表达发挥抗癌作用
Ying Hu,Stefan Rahlfs,Volker Mersch-Sundermann et al.
Ying Hu et al.
Resveratrol is a polyphenolic chemopreventive agent that has been shown to influence cellular redox reactions. As a systematic approach to elucidating the complex effects of resveratrol on eukaryotic cells, we studied its dose-dependent eff...
Apoptotic DNA fragmentation is not related to the phosphorylation state of histone H1 [0.03%]
凋亡DNA片段化与组蛋白H1磷酸化状态无关
Wiebke Goebel,Natalie Obermeyer,Nadja Bleicher et al.
Wiebke Goebel et al.
Changes in chromatin structure, histone phosphorylation and cleavage of DNA into nucleosome-size fragments are characteristic features of apoptosis. Since H1 histones bind to the site of DNA cleavage between nucleosomal cores, the question ...
Hydrophobic bile salts trigger ceramide formation through endosomal acidification [0.03%]
疏水性胆盐通过溶酶体酸化诱导生成鞘氨醇类脂质
Stephan Becker,Roland Reinehr,Susanne Grether-Beck et al.
Stephan Becker et al.
Hydrophobic bile salts activate NADPH oxidase through a ceramide- and PKCzeta-dependent pathway as an important upstream event of bile salt-induced hepatocyte apoptosis. The mechanisms underlying bile salt-induced ceramide formation have re...
Nef protein of human immunodeficiency virus type 1 binds its own myristoylated N-terminus [0.03%]
人类免疫缺陷病毒Ⅰ型的Nef蛋白与其本身的myristoylatedN-末端结合
Silke Hoffmann,Esther Jonas,Simone König et al.
Silke Hoffmann et al.
HIV-1 Nef is a small protein (approx. 25 kDa) that is posttranslationally modified by myristoylation. To explain its complex activities, a 'Nef-cycle' is discussed, which postulates different molecular conformations of Nef. Using recombinan...
Characterisation and glucoregulatory actions of a novel acylated form of the (Pro3)GIP receptor antagonist in type 2 diabetes [0.03%]
2型糖尿病中(GIP)(Pro3)受体拮抗剂的新酰化形式的特征及糖调节作用
Victor A Gault,Kerry Hunter,Nigel Irwin et al.
Victor A Gault et al.
In this study, we tested the biological activity of a novel acylated form of (Pro3)glucose-dependent insulinotropic polypetide [(Pro3)GIP] prepared by conjugating palmitic acid to Lys16 to enhance its efficacy in vivo by promoting binding t...
Comparative thermodynamic analysis of cyclic nucleotide binding to protein kinase A [0.03%]
环核苷酸结合蛋白激酶A的热力学比较分析
Daniela Moll,Sonja Schweinsberg,Christian Hammann et al.
Daniela Moll et al.
We have investigated the thermodynamic parameters and binding of a regulatory subunit of cAMP-dependent protein kinase (PKA) to its natural low-molecular-weight ligand, cAMP, and analogues thereof. For analysis of this model system, we comp...
Comparative Study
Biological chemistry. 2007 Feb;388(2):163-72. DOI:10.1515/BC.2007.018 2007
Daniel Friedrich,Torsten Hoffmann,Joachim Bär et al.
Daniel Friedrich et al.
Mutations in the mouse ATRN gene, which encodes attractin, offer links between this protein and pigmentation, metabolism, immune status and neurodegeneration. However, the mechanisms of attractin action are not understood. The protein was f...
Isolation and characterization of the glutaminyl cyclases from Solanum tuberosum and Arabidopsis thaliana: implications for physiological functions [0.03%]
拟南芥和马铃薯的谷氨酰胺环化酶的分离及特性鉴定及其生理功能意义
Stephan Schilling,Irene Stenzel,Alex von Bohlen et al.
Stephan Schilling et al.
Glutaminyl cyclases (QCs) catalyze the formation of pyroglutamic acid at the N-terminus of several peptides and proteins. On the basis of the amino acid sequence of Carica papaya QC, we identified cDNAs of the putative counterparts from Sol...