GD3 synthase overexpression enhances proliferation and migration of MDA-MB-231 breast cancer cells [0.03%]
GD3合成酶过表达增强MDA-MB-231乳腺癌细胞增殖和迁移能力
Aurélie Cazet,Sophie Groux-Degroote,Béatrice Teylaert et al.
Aurélie Cazet et al.
The disialoganglioside G(D3) is an oncofetal marker of a variety of human tumors including melanoma and neuroblastoma, playing a key role in tumor progression. G(D3) and 9-O-acetyl-G(D3) are overexpressed in approximately 50% of invasive du...
The influenza A virus matrix protein as a marker to monitor initial virus internalisation [0.03%]
流感A病毒基质蛋白作为监测初始病毒内在化的标志物
Thorsten Eierhoff,Stephan Ludwig,Christina Ehrhardt
Thorsten Eierhoff
The uptake of influenza A viruses (IAV) into cells represents an attractive antiviral drug target, e.g., by interfering with essential cellular or viral entry factors. So far, this process could only be studied by time-consuming microscopic...
Management of the human mucosal defensive barrier: evidence for glycan legislation [0.03%]
人类黏膜防御屏障的管理：糖蛋白执政的证据
Georgios Patsos,Anthony Corfield
Georgios Patsos
The human gastrointestinal barrier comprises several layers which enable protection against the external environment. The mucosal epithelium, lamina propria, glycocalyx and secreted mucus each make a contribution to barrier protection. Glyc...
Ralf Hass
Ralf Hass
Cellular differentiation can be characterized by the acquisition of specified properties during several steps of development whereby the original stem- or precursor-like populations can finally obtain a certain phenotype with highly specifi...
3D structure of a binary ROP-PRONE complex: the final intermediate for a complete set of molecular snapshots of the RopGEF reaction [0.03%]
二元ROP-PRONE复合物的三维结构：RopGEF反应完整分子快照系列中的最终中间态
Christoph Thomas,Inka Fricke,Michael Weyand et al.
Christoph Thomas et al.
Guanine nucleotide exchange factors (GEFs) catalyze the activation of GTP-binding proteins (G proteins) in a multi-step reaction comprising intermediary complexes with and without nucleotide. Rho proteins of plants (ROPs) are activated by n...
The liaison between apoptotic cells and macrophages--the end programs the beginning [0.03%]
凋亡细胞与巨噬细胞的联系——结局决定开始
Andreas Weigert,Carla Jennewein,Bernhard Brüne
Andreas Weigert
The efficient execution of apoptotic cell death with the clearance of apoptotic debris by phagocytes is a key regulatory mechanism ensuring tissue homeostasis. Failure in this execution program contributes to the pathogenesis of many human ...
Staphylococcal cysteine protease staphopain B (SspB) induces rapid engulfment of human neutrophils and monocytes by macrophages [0.03%]
金黄色葡萄球菌半胱氨酸蛋白酶staphopain B(SspB)能够迅速诱导中性粒细胞和单核细胞被巨噬细胞吞噬
Jan Smagur,Krzysztof Guzik,Malgorzata Bzowska et al.
Jan Smagur et al.
Abstract Circulating neutrophils and monocytes constitute the first line of antibacterial defence, which is responsible for the phagocytosis and killing of microorganisms. Previously, we have described that the staphylococcal cysteine prote...
Release of endo-lysosomal cathepsins B, D, and L from IEC6 cells in a cell culture model mimicking intestinal manipulation [0.03%]
肠操作的体外细胞模型中IEC6细胞内自噬溶酶体系统中天冬氨酸蛋白酶的释放
Kristina Mayer,Anna Vreemann,Hong Qu et al.
Kristina Mayer et al.
IEC6 cells were used as an in vitro model system to study the effects of cell damage caused by mechanical manipulation of intestine epithelial cells. We constructed an apparatus that allowed analyzing the consequences of mechanical compress...
Protein-specific glycosylation: signal patches and cis-controlling peptidic elements [0.03%]
蛋白质特异性的糖基化：“信号补丁”和顺式控制肽段元素
Franz-Georg Hanisch,Isabelle Breloy
Franz-Georg Hanisch
The term 'protein-specific glycosylation' refers to important functional implications of a subset of glycosylation types that are under direct control of recognition determinants on the protein. Examples of the latter are found in the forma...
The solution structure of pGolemi, a high affinity Mena EVH1 binding miniature protein, suggests explanations for paralog-specific binding to Ena/VASP homology (EVH) 1 domains [0.03%]
pGolemi的溶液结构是一种与Mena EVH1结合的高亲和力微型蛋白，它对Ena/VASP同源(EVH)1区段具有特异性的结合现象给出了可能的解释。
Nina M Link,Cornelia Hunke,Jonathan W Mueller et al.
Nina M Link et al.
Ena/VASP homology 1 (EVH1) domains are polyproline binding domains that are present in a wide range of adaptor proteins, among them Ena/VASP proteins involved in actin remodeling and axonal guidance. The interaction of ActA, a transmembrane...