Post-translational processing of selenoprotein P: implications of glycosylation for its utilisation by target cells [0.03%]
硒蛋白P的翻译后加工：糖基化对其靶细胞利用的影响
Holger Steinbrenner,Lirija Alili,Dominik Stuhlmann et al.
Holger Steinbrenner et al.
Selenoprotein P (SeP) is a highly glycosylated plasma protein containing up to 10 selenocysteine residues. It is secreted by hepatocytes and also by the human hepatoma cell line HepG2. Pharmacological inhibitors interfering with N-glycosyla...
Lutz Schomburg,Cornelia Riese,Kostja Renko et al.
Lutz Schomburg et al.
Clinical data suggest that selenium (Se) supplementation decreases disease predisposition and severity and accelerates recovery in a variety of pathologies. Pre-supplementation Se levels and sex represent important determinants of these Se-...
Activation of the glutathione peroxidase 2 (GPx2) promoter by beta-catenin [0.03%]
β-catenin激活谷胱甘肽过氧化物酶2(GPx2)启动子
Anna Kipp,Antje Banning,Regina Brigelius-Flohé
Anna Kipp
GPx2, formerly named gastrointestinal glutathione peroxidase, is highly expressed in the proliferative area of the intestinal crypt-to-villus axis and in Paneth cells. Additionally, GPx2 is transiently up-regulated during development of gas...
Physiological role of phospholipid hydroperoxide glutathione peroxidase in mammals [0.03%]
哺乳动物磷脂氢过氧化物谷胱甘肽过氧化酶的生理作用
Marcus Conrad,Manuela Schneider,Alexander Seiler et al.
Marcus Conrad et al.
The redox enzyme phospholipid hydroperoxide glutathione peroxidase (PHGPx) has emerged as one of the most significant selenoenzymes in mammals, corroborated by early embryonic lethality of PHGPx null mice. PHGPx is one of five selenium-depe...
Molecular biology of glutathione peroxidase 4: from genomic structure to developmental expression and neural function [0.03%]
谷胱甘肽过氧化物酶4的分子生物学：从基因组结构到发育表达和神经功能
Nicolai E Savaskan,Christoph Ufer,Hartmut Kühn et al.
Nicolai E Savaskan et al.
Selenoproteins have been recognized as modulators of brain function and signaling. Phospholipid hydroperoxide glutathione peroxidase (GPx4/PHGPx) is a unique member of the selenium-dependent glutathione peroxidases in mammals with a pivotal...
Ludger A Wessjohann,Alex Schneider,Muhammad Abbas et al.
Ludger A Wessjohann et al.
What makes selenoenzymes--seen from a chemist's view--so special that they cannot be substituted by just more analogous or adapted sulfur proteins? This review compiles and compares physicochemical properties of selenium and sulfur, synthet...
Leopold Flohé
Leopold Flohé
The role of selenium in male fertility is reviewed with special emphasis on selenoprotein P and phospholipid hydroperoxide glutathione peroxidase (GPx4) in spermiogenesis. Inverse genetics reveal that selenoprotein P is required for seleniu...
August Böck,Leopold Flohé,Josef Köhrle
August Böck
Cysteine protease inhibitors reduce brain beta-amyloid and beta-secretase activity in vivo and are potential Alzheimer's disease therapeutics [0.03%]
半胱氨酸蛋白酶抑制剂可降低体内脑β淀粉样蛋白及β分泌酶活性并有望成为治疗阿尔茨海默病的药物
Gregory Hook,Vivian Y H Hook,Mark Kindy
Gregory Hook
Beta-secretase inhibitors that lower brain beta-amyloid peptides (Abeta) are likely to be effective for treating Alzheimer's disease (AD). Irreversible epoxysuccinyl cysteine protease inhibitors are known to reduce brain Abeta and beta-secr...
Josephin domain-containing proteins from a variety of species are active de-ubiquitination enzymes [0.03%]
来自各种物种的约瑟夫环结构域蛋白是具有去泛素化活性的酶
Nikolay Tzvetkov,Peter Breuer
Nikolay Tzvetkov
The neurodegenerative disease spinocerebellar ataxia type 3 (SCA3) is caused by the presence of an extended polyglutamine stretch (polyQ) in the unstructured C-terminus of the human ataxin-3 (AT3) protein. The structured N-terminal Josephin...