On-line nano-HPLC/ESI QTOF MS monitoring of alpha2-3 and alpha2-6 sialylation in granulocyte glycosphingolipidome [0.03%]
在线nano-HPLC / ESI QTOF MS监测粒细胞糖基鞘脂α2-3和α2-6唾液酸化
Stephan Kirsch,Johannes Müthing,Jasna Peter-Katalinić et al.
Stephan Kirsch et al.
A novel glycosphingolipidomic protocol using nano-high performance liquid chromatography coupled on-line to electrospray ionization quadrupole time-of-flight mass spectrometry (ESI-QTOF-MS) focusing on the separation of isomeric ganglioside...
Natasha M Ng,Robert N Pike,Sarah E Boyd
Natasha M Ng
Proteases play vital roles in a range of biological processes, such as cell cycle, cell growth and differentiation, apoptosis, haemostasis and signalling. Fundamental to our knowledge of protease action is an understanding of how the active...
Cooperative effects in the substrate specificity of the complement protease C1s [0.03%]
补体蛋白酶C1s的底物特异性的协同效应
Sarah E Boyd,Felicity K Kerr,David W Albrecht et al.
Sarah E Boyd et al.
Complement is a key component of the immune system, but can contribute to inflammatory diseases. The substrate specificity of C1s protease has been successfully investigated using a combinatorial approach, while a positional scanning method...
Role of the polypeptide backbone and post-translational modifications in cross-reactivity of Art v 1, the major mugwort pollen allergen [0.03%]
肽基主链和翻译后修饰在艾草花粉主要致敏蛋白Art v 1交叉反应性中的作用研究
Petra Gruber,Gabriele Gadermaier,Roman Bauer et al.
Petra Gruber et al.
Artemisia vulgaris (mugwort) is one of the main causes of late summer pollinosis in Europe, with >95% of patients sensitized to the glycoallergen Art v 1. Despite the importance of this allergen, little is known about its cross-reactive beh...
Identification and characterization of a bioactive lantibiotic produced by Staphylococcus warneri [0.03%]
一种生物活性环肽抗生素的鉴定和表征
Jørgen Petersen,Anders Boysen,Lotte Fogh et al.
Jørgen Petersen et al.
Lantibiotics are a group of potent antibacterial agents that contain unusual amino acids, such as the thioether amino acids lanthionine and methyllanthionine, and the didehydroamino acids didehydroalanine and didehydro-aminobutyric acid. He...
Identification of parasite-responsive cysteine proteases in Manduca sexta [0.03%]
曼陀林六世中寄生虫反应性半胱氨酸蛋白酶的鉴定
Céline Serbielle,Sébastien Moreau,Florian Veillard et al.
Céline Serbielle et al.
Parasites have evolved different virulence strategies to manipulate host physiological functions. The parasitoid wasp Cotesia congregata induces developmental arrest and immune suppression of its Lepidopteran host Manduca sexta. In this int...
Krüppel-like factor 4 represses transcription of the survivin gene in esophageal cancer cell lines [0.03%]
Krüppel样因子4通过抑制转录在食管癌细胞系中负向调节survivin基因表达
Guo Zhang,Hongxia Zhu,Yihua Wang et al.
Guo Zhang et al.
Aberrant expression of survivin has been shown to be regulated at the transcription level in cancer cells. In this study, we demonstrate that there are six putative binding sites of Krüppel-like factor 4 (KLF4) within the 2000-bp region up...
Beyond glycosylation: sialic acid precursors act as signaling molecules and are involved in cellular control of differentiation of PC12 cells [0.03%]
超越糖基化：唾液酸前体作为信号分子参与PC12细胞分化过程的细胞调控作用
Maria Kontou,Wenke Weidemann,Kaya Bork et al.
Maria Kontou et al.
Sialic acids represent a family of 9-carbon acidic amino sugars expressed mainly as terminal monosaccharides on most mammalian glycoconjugates. Sialic acids play an outstanding role during cellular processes, such as development and regener...
Thomas Zögg,Hans Brandstetter
Thomas Zögg
Blood haemostasis is accomplished by a complex network of coagulatory and fibrinolytic processes. These processes have to be delicately balanced, as clinically manifested by bleeding disorders, such as haemophilia A and B. These disorders a...
Cathepsin B release from rodent intestine mucosa due to mechanical injury results in extracellular matrix damage in early post-traumatic phases [0.03%]
机械损伤导致的小鼠肠黏膜猫肉蛋白B释放对早期创伤后基质金属蛋白酶活性及细胞外基质的影响研究
Anna Vreemann,Hong Qu,Kristina Mayer et al.
Anna Vreemann et al.
An in vivo model was used to investigate the role of cathepsins in mouse intestine after mechanical manipulation. Inspection of different intestine segments by immunofluorescence microscopy provided evidence for a local release of cathepsin...