Fabin, a novel calcyon-like and glucanase-like protein with mitogenic, antifungal and translation-inhibitory activities from broad beans [0.03%]
来源于菜豆的一种具有促有丝分裂、抗真菌和抑制翻译作用的新型calcyon-like和葡聚糖酶_like蛋白
T B Ng,X Y Ye
T B Ng
A protein with an N-terminal sequence displaying similarities to N-terminal sequences of human calcyon and barley endo-1,4-glucanase, and to C-terminal sequences of human translation initiation factor 4 gamma and yeast superkiller viralicid...
Contribution of the absolutely conserved B8Gly to the foldability of insulin [0.03%]
绝对保守的B8Gly残基对胰岛素可折叠性的影响研究
Zhan-Yun Guo,Yue-Hua Tang,Shuai Wang et al.
Zhan-Yun Guo et al.
B8Gly is absolutely conserved in insulin from different species, and in other members of the insulin superfamily the corresponding position is always occupied by a Gly residue. However, the reasons for its conservation are still unclear; pr...
Comparative Study
Biological chemistry. 2003 May;384(5):805-9. DOI:10.1515/BC.2003.089 2003
Intra- and interspecies interactions between prion proteins and effects of mutations and polymorphisms [0.03%]
朊病毒蛋白的种内和种间相互作用及其突变和多态性的影响
Christoph Hundt,Sabine Gauczynski,Christoph Leucht et al.
Christoph Hundt et al.
Recently, crystallization of the prion protein in a dimeric form was reported. Here we show that native soluble homogeneous FLAG-tagged prion proteins from hamster, man and cattle expressed in the baculovirus system are predominantly dimeri...
Treatment of tumor cells with histone deacetylase inhibitors results in altered recruitment of methyl-CpG binding proteins to a methylated CpG island [0.03%]
组蛋白去乙酰基酶抑制剂处理肿瘤细胞后会使高甲基化CpG岛上着丝分裂染色体结合蛋白的募集发生改变
Shiro Koizume,Ken Tachibana,Masahiko Shiraishi
Shiro Koizume
When human cancer cells with silencing of the CDH1 gene associated with CpG island methylation and histone deacetylation were treated with histone deacetylase inhibitors, alteration in recruitment of methyl-CpG binding proteins (MBPs) to th...
Trichostatin A and structurally related histone deacetylase inhibitors induce 5-lipoxygenase promoter activity [0.03%]
曲霉抗生素表皮素等组蛋白脱乙酰基酶抑制剂诱导5-脂氧合酶启动子活性
Niko Klan,Sabine Seuter,Nicole Schnur et al.
Niko Klan et al.
5-Lipoxygenase (5-LO) mRNA expression in Mono Mac 6 cells is induced by the histone deacetylase inhibitor trichostatin A (TsA). In order to study the effects of TsA and several structurally related compounds such as MD85, D237 and M232 on 5...
Identification and characterization of KAT, a novel gene preferentially expressed in several human cancer cell lines [0.03%]
KAT基因的鉴定及表征：一个在人类癌细胞系中特异表达的新基因
Katrin Wenzel,Stephan B Felix,Christina Flachmeier et al.
Katrin Wenzel et al.
We describe the molecular characterization of a novel human gene on chromosome 1q23.3, termed KAT, which is highly conserved among mammals. The KAT gene spans a genomic region of approximately 1.6 kilobases and consists of 4 exons encoding ...
Transcriptional regulation of the urokinase receptor (u-PAR)--a central molecule of invasion and metastasis [0.03%]
尿激酶受体（u-PAR）的转录调控——一种侵袭和转移的核心分子
Tina Fuchs,Heike Allgayer
Tina Fuchs
The phenomenon of tumor-associated proteolysis has been acknowledged as a decisive step in the progression of cancer. This short review focuses on the urokinase receptor (u-PAR), a central molecule involved in tumor-associated invasion and ...
Hiroshi Kobayashi,Mika Suzuki,Yasuyuki Hirashima et al.
Hiroshi Kobayashi et al.
Bikunin is a Kunitz-type protease inhibitor predominantly found in human amniotic fluid. In cancers, administration of bikunin may block tumor cell invasion by a direct inhibition of tumor cell-associated plasmin activity as well as by inhi...
Christian Plank,Ulrike Schillinger,Franz Scherer et al.
Christian Plank et al.
In order to enhance and target gene delivery we have previously established a novel method, termed magnetofection, which uses magnetic force acting on gene vectors that are associated with magnetic particles. Here we review the benefits, th...
Age-dependent effects of conditioning on cholinergic and vasopressin systems in the rat suprachiasmatic nucleus [0.03%]
有关条件作用对Sprague-Dawley大鼠视交叉上核胆碱能和血管加压素系统年龄依赖性影响的研究
Barbara A Biemans,Eddy A Van der Zee,Serge Daan
Barbara A Biemans
Active shock avoidance was used to explore the impact of behavioural stimulation on the neurochemistry of the suprachiasmatic nucleus. We have found previously that the expression of muscarinic acetylcholine receptors in the suprachiasmatic...
Comparative Study
Biological chemistry. 2003 May;384(5):729-36. DOI:10.1515/BC.2003.081 2003