Construction of an encapsulated ESAT-6-based anti-TB DNA vaccine and evaluation of its immunogenic properties [0.03%]
构建并评价一种新型抗结核ESAT-6基因疫苗的免疫原性
Olesya Nosareva,Andrey Nesterov,Alexander Boldyrev et al.
Olesya Nosareva et al.
Experimental preparations based on a DNA vaccine encoding the ESAT-6 antigen of Mycobacterium tuberculosis have been obtained (KpONE6) and studied for immunogenic effects in the murine model. The core of the preparation contains DNA of the ...
Pre-clinical development of cell culture (Vero)-derived H5N1 pandemic vaccines [0.03%]
用于开发H5N1大流行疫苗的细胞培养（VERO）的临床前研究
M Keith Howard,Otfried Kistner,P Noel Barrett
M Keith Howard
The rapid spread of avian influenza (H5N1) and its transmission to humans has raised the possibility of an imminent pandemic and concerns over the ability of standard influenza vaccine production methods to supply sufficient amounts of an e...
Non-regulatory CD8+CD45RO+CD25+ T-lymphocytes may compensate for the loss of antigen-inexperienced CD8+CD45RA+ T-cells in old age [0.03%]
非调节性CD8+CD45RO+CD25+T淋巴细胞可能弥补了老年时期抗原新手型CD8+CD45RA+T细胞的丢失现象
Dietmar Herndler-Brandstetter,Ellen Veel,Gerhard T Laschober et al.
Dietmar Herndler-Brandstetter et al.
The age-related decline in immune system functions is responsible for the increased prevalence of infectious diseases and the low efficacy of vaccination in elderly individuals. In particular, the number of peripheral naive T-cells declines...
Comparative Study
Biological chemistry. 2008 May;389(5):561-8. DOI:10.1515/bc.2008.052 2008
Analysis of the human cytomegalovirus pp65-directed T-cell response in healthy HLA-A2-positive individuals [0.03%]
健康HLA-A2阳性个体中的人巨细胞病毒pp65定向T细胞反应分析
Juliane Schalich,Oresta Vytvytska,Wolfgang Zauner et al.
Juliane Schalich et al.
Human cytomegalovirus (HCMV) is contained by T-lymphocyte responses focused towards the major tegument protein pp65. To systematically identify T-cell epitopes, we applied the following strategy: 441 overlapping 15mer peptides spanning the ...
Erich Tauber,Shailesh Dewasthaly
Erich Tauber
Japanese encephalitis causes serious health problems in countries in Southeast Asia, where the causative virus is endemic. Whereas most adults living in this region have acquired immunity, children are at high risk of infection. Childhood m...
Michael G Tovey,Christophe Lallemand,George Thyphronitis
Michael G Tovey
Type I interferons (IFNs) produced primarily by plasmacytoid dendritic cells (pDCs) as part of the innate immune response to infectious agents induce the maturation of myeloid DCs and enhance antigen presentation. Type I IFNs also enhance a...
Jens Wrammert,Rafi Ahmed
Jens Wrammert
Long-lived plasma cells are key to maintaining long-term humoral immunity after infection or vaccination. Some vaccines and/or infections induce antibody levels that remain stable for the life of the individual. However, the mechanism where...
Gary T Jennings,Martin F Bachmann
Gary T Jennings
Virus-like particles are supra-molecular assemblages, usually icosahedral or rod-like structures. They incorporate key immunologic features of viruses which include repetitive surfaces, particulate structures and induction of innate immunit...
Lipopolysaccharide: a tool and target in enterobacterial vaccine development [0.03%]
脂多糖：肠道细菌疫苗开发中的工具和靶标
Gábor Nagy,Tibor Pál
Gábor Nagy
Lipopolysaccharide (LPS) is an essential component of Gram-negative bacteria. While mutants exhibiting truncated LPS molecules are usually over-attenuated, alternative approaches that affect the extent or timing of LPS expression, as well a...
Not to wake a sleeping giant: new insights into host-pathogen interactions identify new targets for vaccination against latent Mycobacterium tuberculosis infection [0.03%]
别惹沉睡的巨人：新的宿主-病原菌互作研究为结核分枝杆菌潜伏感染的疫苗研发提供新思路
May Young Lin,Tom H M Ottenhoff
May Young Lin
Mycobacterium tuberculosis is one of the worlds' most successful and sophisticated pathogens. It is estimated that over 2 billion people today harbour latent M. tuberculosis infection without any clinical symptoms. As most new cases of acti...