Franz-Georg Hanisch
Franz-Georg Hanisch
MUC1 traverses apical recycling endosomes along the biosynthetic pathway in polarized MDCK cells [0.03%]
MUC1沿生物合成途径穿过极化MDCK细胞顶端回收内吞小体
Polly E Mattila,Carol L Kinlough,Jennifer R Bruns et al.
Polly E Mattila et al.
MUC1 is a heavily glycosylated transmembrane protein localized at the apical surface of polarized epithelial cells. Here, we examined the biosynthetic route of newly synthesized MUC1 in polarized Madin-Darby canine kidney (MDCK) cells. Apic...
Brain development needs sugar: the role of polysialic acid in controlling NCAM functions [0.03%]
大脑发育需要糖：多聚唾液酸在控制神经细胞黏附分子功能中的作用
Martina Mühlenhoff,Imke Oltmann-Norden,Birgit Weinhold et al.
Martina Mühlenhoff et al.
Polysialic acid (polySia) is a major regulator of cell-cell interactions in the developing nervous system and a key factor in maintaining neural plasticity. As a polyanionic molecule with high water binding capacity, polySia increases the i...
Impact of glycosylation and detergent-resistant membranes on the function of intestinal sucrase-isomaltase [0.03%]
糖基化和耐洗涤剂膜对肠蔗糖异构酶功能的影响
Gabi Wetzel,Martin Heine,Arndt Rohwedder et al.
Gabi Wetzel et al.
Sucrase-isomaltase (SI) is a highly N- and O-glycosylated intestinal brush border membrane protein. SI is sorted with high fidelity to the apical membrane via O-linked glycans that mediate its association with lipid rafts or detergent-resis...
Glycosylation- and phosphorylation-dependent intracellular transport of lysosomal hydrolases [0.03%]
糖基化和磷酸化依赖的溶酶体水解酶胞内运输
Sandra Pohl,Katrin Marschner,Stephan Storch et al.
Sandra Pohl et al.
Lysosomes contain more than 50 soluble hydrolases that are targeted to lysosomes in a mannose 6-phosphate (Man6P)-dependent manner. The phosphorylation of man- nose residues on high mannose-type oligosaccharides of newly synthesized lysosom...
Glycosylation pattern of brush border-associated glycoproteins in enterocyte-like cells: involvement of complex-type N-glycans in apical trafficking [0.03%]
类似肠细胞的刷状缘相关糖蛋白糖基化模式：复糖N-寡糖参与顶极转运
Willy Morelle,Laurence Stechly,Sabine André et al.
Willy Morelle et al.
We have previously reported that galectin-4, a tandem repeat-type galectin, regulates the raft-dependent delivery of glycoproteins to the apical brush border membrane of enterocyte-like HT-29 cells. N-Acetyllactos-amine-containing glycans, ...
Regulation and pathophysiological implications of UDP-GlcNAc 2-epimerase/ManNAc kinase (GNE) as the key enzyme of sialic acid biosynthesis [0.03%]
UDP-GlcNAc 2-差向异构酶/ManNAc激酶(GNE)的调节及其作为唾液酸生物合成关键酶的病理生理意义
Stefan O Reinke,Gerhard Lehmer,Stephan Hinderlich et al.
Stefan O Reinke et al.
The key enzyme for the biosynthesis of N-acetylneuraminic acid, from which all other sialic acids are formed, is the bifunctional enzyme UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase (GNE). GNE is a highly conserved protein...
From structural to functional glycomics: core substitutions as molecular switches for shape and lectin affinity of N-glycans [0.03%]
从结构糖组学到功能糖组学：N-聚糖的核心取代作为构象和凝集素亲和力的分子开关
Sabine André,Tibor Kozár,Shuji Kojima et al.
Sabine André et al.
Glycan epitopes of cellular glycoconjugates act as versatile biochemical signals (sugar coding). Here, we test the hypothesis that the common N-glycan modifications by core fucosylation and introduction of the bisecting N-acetylglucosamine ...
Yan Liu,Angelina S Palma,Ten Feizi
Yan Liu
Carbohydrate chains of glycoproteins, glycolipids, proteoglycans, and polysaccharides mediate processes of biological and medical importance through their interactions with complementary proteins. The unraveling of these interactions is the...
Tumor-associated MUC1 glycopeptide epitopes are not subject to self-tolerance and improve responses to MUC1 peptide epitopes in MUC1 transgenic mice [0.03%]
肿瘤相关MUC1糖肽表位不受自身耐受限制且能够改善MUC1转基因小鼠中MUC1肽表位的反应
Sean O Ryan,Anda M Vlad,Kazi Islam et al.
Sean O Ryan et al.
Human adenocarcinomas overexpress a hypoglycosylated, tumor-associated form of the mucin-like glycoprotein MUC1 containing abnormal mono- and disaccharide antigens, such as Tn, sialyl-Tn, and TF, as well as stretches of unglycosylated prote...