Glycosylation- and phosphorylation-dependent intracellular transport of lysosomal hydrolases
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Lysosomes contain more than 50 soluble hydrolases that are targeted to lysosomes in a mannose 6-phosphate (Man6P)-dependent manner. The phosphorylation of man- nose residues on high mannose-type oligosaccharides of newly synthesized lysosomal enzymes is cataly... ...
