Downregulated XPA promotes carcinogenesis of bladder cancer via impairment of DNA repair [0.03%]
XPA转录下调通过抑制DNA修复促进膀胱癌的致癌作用
Yi Zhi,Huixiang Ji,Jinhong Pan et al.
Yi Zhi et al.
Bladder cancer is the most common malignant tumor of urinary system, largely resulting from failure of repair of DNA damage to the environmental insults. The function of XPA in nucleotide excision repair pathway has been well documented. Ho...
Hematological parameters during concurrent chemoradiotherapy as potential prognosticators in patients with stage IIB cervical cancer [0.03%]
同步放化疗期间血常规指标作为ⅡB期宫颈癌患者预后因素的潜在预测因子分析
Oyeon Cho,O Kyu Noh,Young-Taek Oh et al.
Oyeon Cho et al.
We hypothesized that hemoglobin levels, absolute neutrophil count, and absolute lymphocyte count were associated with radiotherapy response and cancer progression and that they might reflect tumor repopulation during concurrent chemoradioth...
Curcumin inhibits cancer progression through regulating expression of microRNAs [0.03%]
姜黄素通过调节microRNA的表达抑制癌症的发展
Siying Zhou,Sijie Zhang,Hongyu Shen et al.
Siying Zhou et al.
Curcumin, a major yellow pigment and spice in turmeric and curry, is a powerful anti-cancer agent. The anti-tumor activities of curcumin include inhibition of tumor proliferation, angiogenesis, invasion and metastasis, induction of tumor ap...
Dynamic tracing for epidermal growth factor receptor mutations in urinary circulating DNA in gastric cancer patients [0.03%]
胃癌患者尿液循环DNA中表皮生长因子受体突变的动态监测研究
Xiu-Qin Shi,Wen-Hua Xue,Song-Feng Zhao et al.
Xiu-Qin Shi et al.
The mutations of epidermal growth factor receptor are detected in gastric cancer, indicating its suitability as a target for receptor tyrosine kinase inhibitors, as well as a marker for clinical outcome of chemotherapeutic treatments. Howev...
MicroRNAs regulate the epithelial-mesenchymal transition and influence breast cancer invasion and metastasis [0.03%]
微小核糖核酸调节上皮间质转化并影响乳腺癌浸润和转移
Min Zhao,Lin Ang,Jin Huang et al.
Min Zhao et al.
MicroRNAs are small RNA molecules that play a major role in the post-transcriptional regulation of genes and influence the development, differentiation, proliferation, and apoptosis of cells and the development and progression of tumors. Th...
Prevalence and coexistence of KRAS, BRAF, PIK3CA, NRAS, TP53, and APC mutations in Indian colorectal cancer patients: Next-generation sequencing-based cohort study [0.03%]
基于下一代测序的队列研究：印度结直肠癌患者中KRAS、BRAF、PIK3CA、NRAS、TP53和APC基因突变的发生率及其共存性
Mayank Jauhri,Akanksha Bhatnagar,Satish Gupta et al.
Mayank Jauhri et al.
Colorectal cancer incidences are on a rise in India. In this study, we have analyzed the mutation frequencies of six potential biomarkers, their coexistence, association with clinicopathological characteristics, and tumor location in Indian...
miR-29a suppresses MCF-7 cell growth by downregulating tumor necrosis factor receptor 1 [0.03%]
微RNA-29a通过下调肿瘤坏死因子受体1抑制MCF-7细胞增殖
Yiling Zhao,Fenghua Yang,Wenyuan Li et al.
Yiling Zhao et al.
Tumor necrosis factor receptor 1 is the main receptor mediating many tumor necrosis factor-alpha-induced cellular events. Some studies have shown that tumor necrosis factor receptor 1 promotes tumorigenesis by activating nuclear factor-kapp...
FOXF2 promoter methylation is associated with prognosis in esophageal squamous cell carcinoma [0.03%]
FOXF2启动子甲基化与食管鳞癌预后相关性研究
Xiaoying Chen,Haochang Hu,Jing Liu et al.
Xiaoying Chen et al.
Esophageal squamous cell carcinoma is a commonly malignant tumor of digestive tract with poor prognosis. Previous studies suggested that forkhead box F2 ( FOXF2) could be a candidate gene for assessing and predicting the prognosis of human ...
Thyroid transcription factor 1 expression is associated with outcome of patients with non-squamous non-small cell lung cancer treated with pemetrexed-based chemotherapy [0.03%]
甲状腺转录因子1表达与培美曲塞为基础的化疗治疗非小细胞非鳞状细胞肺癌患者预后的关系研究
Ondrej Fiala,Milos Pesek,Jana Skrickova et al.
Ondrej Fiala et al.
Pemetrexed is an antifolate cytostatic agent targeting several folate-dependent enzymatic pathways, widely used in the treatment of locally advanced or metastatic stage non-small cell lung cancer. Aside from the non-squamous histology, ther...
Matthew D Johnson,Brandon Stone,Bryan J Thibodeau et al.
Matthew D Johnson et al.
This study investigated the Trk receptor family as a therapeutic target in pancreatic ductal adenocarcinoma and assessed their prognostic significance. Global gene expression analysis was investigated in prospectively collected pancreatic d...