Deep sequencing of the TP53 gene reveals a potential risk allele for non-small cell lung cancer and supports the negative prognostic value of TP53 variants [0.03%]
TP53基因的深度测序发现了一个非小细胞肺癌潜在的风险等位基因，并支持了TP53变异体的负面预后价值
Christophe Deben,Jolien Van den Bossche,Nele Van Der Steen et al.
Christophe Deben et al.
The TP53 gene remains the most frequently altered gene in human cancer, of which variants are associated with cancer risk, therapy resistance, and poor prognosis in several tumor types. To determine the true prognostic value of TP53 variant...
Granulocyte-macrophage colony-stimulating factor increases tumor growth and angiogenesis directly by promoting endothelial cell function and indirectly by enhancing the mobilization and recruitment of proangiogenic granulocytes [0.03%]
粒细胞-巨噬细胞集落刺激因子通过促进内皮细胞功能直接和通过增强促血管生成粒细胞的动员和募集间接增加肿瘤生长和血管生成
Qiaowei Zheng,Xueqian Li,Xiaoliang Cheng et al.
Qiaowei Zheng et al.
Granulocyte-macrophage colony-stimulating factor has been widely used as an adjuvant therapy for cancer patients exhibiting myelosuppression induced by chemotherapy or radiotherapy. However, the effects of granulocyte-macrophage colony-stim...
Pedigree and BRCA gene analysis in breast cancer patients to identify hereditary breast and ovarian cancer syndrome to prevent morbidity and mortality of disease in Indian population [0.03%]
乳腺癌患者的系谱和BRCA基因分析以识别遗传性乳腺癌和卵巢癌综合征以预防印度人群的疾病伤残和死亡率
Mina Darooei,Subhadra Poornima,Bibi Umae Salma et al.
Mina Darooei et al.
Global burden of breast cancer is expected to increase to >2 million new cases every year by 2030 and 10% of these are likely to have hereditary breast and ovarian cancer syndrome. Identifying these individuals by pedigree and BRCA1/2 mutat...
Anna-Laura Kretz,Monika Schaum,Julia Richter et al.
Anna-Laura Kretz et al.
Despite recent advances in diagnosis and therapy, prognosis of pancreatic cancer still remains very poor. Besides valid prognostic markers, novel therapeutic approaches are urgently needed. The family of cyclin-dependent kinases comprises 2...
Orai1 mediates tumor-promoting store-operated Ca2+ entry in human gastrointestinal stromal tumors via c-KIT and the extracellular signal-regulated kinase pathway [0.03%]
Orai1通过c-KIT和细胞外信号调节酶（ERK）途径介导人类胃肠道间质瘤的肿瘤促进型库运营操作Ca2+在人类胃肠stromal肉瘤中的作用入口
Lei Wang,Jiaqi Hao,Yijian Zhang et al.
Lei Wang et al.
Gastrointestinal stromal tumors originate from interstitial cells of Cajal, the pacemaker cells of the gut. Ca2+ regulates the pacemaker activity of interstitial cells of Cajal. Store-operated Ca2+ entry mediates the majority of Ca2+ entry ...
Beta-1,4-galactosyltransferase II predicts poor prognosis of patients with non-metastatic clear-cell renal cell carcinoma [0.03%]
β-1,4-半乳糖基转移酶II可预测非转移性透明细胞肾癌患者的不良预后
Haijian Zhang,Yidong Liu,Huyang Xie et al.
Haijian Zhang et al.
Beta-1,4-galactosyltransferase II is found to be associated with the alterations of tumor-related glycosylation. However, the clinical significance of beta-1,4-galactosyltransferase II in non-metastatic clear-cell renal cell carcinoma has n...
Long non-coding RNA XIST promotes cell growth by regulating miR-139-5p/PDK1/AKT axis in hepatocellular carcinoma [0.03%]
长链非编码RNA XIST通过调节miR-139-5p/PDK1/AKT轴促进肝癌细胞增殖
Yichao Mo,Yaoyong Lu,Peng Wang et al.
Yichao Mo et al.
Abnormal expression of long non-coding RNA often contributes to unrestricted growth of cancer cells. Long non-coding RNA XIST expression is upregulated in several cancers; however, its modulatory mechanisms have not been reported in hepatoc...
The pseudogene-derived long noncoding RNA SFTA1P is down-regulated and suppresses cell migration and invasion in lung adenocarcinoma [0.03%]
肺腺癌中由假基因衍生的长非编码RNA SFTA1P下调并抑制细胞迁移和侵袭
Hua Zhang,Yaqiong Xiong,Rui Xia et al.
Hua Zhang et al.
Pseudogenes were once considered to be genomic fossils without biological function. Interestingly, recent evidence showed that a lot of pseudogenes are transcribed in human cancers, and their alterations contribute to multiple cancer develo...
Protein arginine N-methyltransferase 1 promotes the proliferation and metastasis of hepatocellular carcinoma cells [0.03%]
脯氨酸-精氨酸N-甲基转移酶1促进肝癌细胞增殖和转移的作用及机制研究
Qing Gou,ShuJiao He,ZeJian Zhou
Qing Gou
Hepatocellular carcinoma is the most common subtype of liver cancer. Protein arginine N-methyltransferase 1 was shown to be upregulated in various cancers. However, the role of protein arginine N-methyltransferase 1 in hepatocellular carcin...
Cancer chemoprevention by an adenosine derivative in a model of cirrhosis-hepatocellular carcinoma induced by diethylnitrosamine in rats [0.03%]
腺苷衍生物通过抑制二乙基亚硝胺诱导的大鼠肝纤维化-肝细胞癌模型中的化学预防癌症的作用
Gabriela Velasco-Loyden,Lidia Pérez-Martínez,Susana Vidrio-Gómez et al.
Gabriela Velasco-Loyden et al.
Hepatocellular carcinoma is one of the most common cancers, and approximately 80% develop from cirrhotic livers. We have previously shown that the aspartate salt of adenosine prevents and reverses carbon tetrachloride-induced liver fibrosis...