Overexpression of miR-10b in colorectal cancer patients: Correlation with TWIST-1 and E-cadherin expression [0.03%]
结直肠癌患者中miR-10b过度表达与TWIST-1和E-钙黏蛋白的表达相关性研究
Rania Abdelmaksoud-Dammak,Nour Chamtouri,Mouna Triki et al.
Rania Abdelmaksoud-Dammak et al.
MicroRNAs are emergent players of epigenetics that function as oncogenes or tumor suppressors and that have been implicated in regulating diverse cellular pathways. MiR-10b is an oncogenic microRNA involved in tumor invasion and metastasis ...
Recurrent epigenetic silencing of the PTPRD tumor suppressor in laryngeal squamous cell carcinoma [0.03%]
喉部鳞状细胞癌中PTPRD肿瘤抑制因子的表观遗传学沉默现象反复出现
Marcin Szaumkessel,Sonia Wojciechowska,Joanna Janiszewska et al.
Marcin Szaumkessel et al.
Cellular processes like differentiation, mitotic cycle, and cell growth are regulated by tyrosine kinases with known oncogenic potential and tyrosine phosphatases that downmodulate the first. Therefore, tyrosine phosphatases are recurrent t...
Genome-wide profiling of micro-RNA expression in gefitinib-resistant human lung adenocarcinoma using microarray for the identification of miR-149-5p modulation [0.03%]
基于微阵列的基因芯片技术检测吉非替尼耐药人肺腺癌microRNA表达谱及miR-149-5p功能研究
Yong Hu,Xiaobing Qin,Dali Yan et al.
Yong Hu et al.
To understand the mechanism involved in gefitinib resistance, we established gefitinib-resistant human HCC827/GR-8-1 cell line from the parental HCC827 cell line. We compared the micro-RNA expression profiles of the HCC827 cells HCC827/GR-8...
Tumor suppressor miR-29c regulates radioresistance in lung cancer cells [0.03%]
miR-29c抑制剂调节肺癌细胞的放射抵抗性
Elena Arechaga-Ocampo,Cesar Lopez-Camarillo,Nicolas Villegas-Sepulveda et al.
Elena Arechaga-Ocampo et al.
Radiotherapy is an important treatment option for non-small cell lung carcinoma patients. Despite the appropriate use of radiotherapy, radioresistance is a biological behavior of cancer cells that limits the efficacy of this treatment. Dere...
l-Glutamine supplementation promotes an improved energetic balance in Walker-256 tumor-bearing rats [0.03%]
鸟氨酸胲补充可改善Walker-256荷瘤大鼠的能量平衡
Heber Amilcar Martins,Roberto Barbosa Bazotte,Geraldo Emilio Vicentini et al.
Heber Amilcar Martins et al.
We evaluated the effects of supplementation with oral l-glutamine in Walker-256 tumor-bearing rats. A total of 32 male Wistar rats aged 54 days were randomly divided into four groups: rats without Walker-256 tumor, that is, control rats (C ...
The impact of advanced proteomics in the search for markers and therapeutic targets of bladder cancer [0.03%]
先进蛋白质组学在膀胱癌标记物和治疗靶点研究中的影响
Hongshuo Zhang,Yue Fan,Lingling Xia et al.
Hongshuo Zhang et al.
Bladder cancer is the most common cancer of the urinary tract and can be avoided through proper surveillance and monitoring. Several genetic factors are known to contribute to the progression of bladder cancer, many of which produce molecul...
Plasma matrix metalloprotease 9 correlates with blood lymphocytosis, leukemic cell invasiveness, and prognosis in B-cell chronic lymphocytic leukemia [0.03%]
血浆基质金属蛋白酶9与B细胞慢性淋巴细胞白血病的血液淋巴细胞增多、白血病细胞侵袭性及预后相关
Milena Gusella,Caterina Bolzonella,Rossella Paolini et al.
Milena Gusella et al.
The complex biology underlying chronic lymphocytic leukemia cell migration and tissue invasiveness is not yet completely understood and might provide novel predictive markers and therapeutic targets. A total of 36 patients out of treatment ...
Paclitaxel resistance development is associated with biphasic changes in reactive oxygen species, mitochondrial membrane potential and autophagy with elevated energy production capacity in lung cancer cells: A chronological study [0.03%]
紫杉醇耐药人肺癌细胞株中活性氧、线粒体膜电位及自噬的阶段性变化与耐药相关性研究
Satabdi Datta,Diptiman Choudhury,Amlan Das et al.
Satabdi Datta et al.
Paclitaxel (Tx) is one of the first-line chemotherapeutic drugs used against lung cancer, but acquired resistance to this drug is a major challenge against successful chemotherapy. In this work, we have focused on the chronological changes ...
MicroRNA-185 induces potent autophagy via AKT signaling in hepatocellular carcinoma [0.03%]
microRNA-185通过AKT信号诱导肝癌细胞发生自噬
Li Zhou,Shunai Liu,Ming Han et al.
Li Zhou et al.
Studies have demonstrated that microRNA 185 may be a promising therapeutic target in liver cancer. However, its role in hepatocellular carcinoma is largely unknown. In this study, the proliferation of human HepG2 cells was inhibited by tran...
LDOC1 regulates Wnt5a expression and osteosarcoma cell metastasis and is correlated with the survival of osteosarcoma patients [0.03%]
LDOC1调节Wnt5a表达及骨肉瘤细胞转移，并与骨肉瘤患者的生存率相关性研究
Bi-Cheng Yong,Jin-Chang Lu,Xian-Biao Xie et al.
Bi-Cheng Yong et al.
Osteosarcomas are common bone malignancies in children and adolescents. LDOC1 (leucine zipper, down-regulated in cancer 1), a tumor suppressor, is down-regulated in many cancers. In this study, we investigated the role of LDOC1 in tumor met...