Tumor-associated calcium signal transducer 2 regulates neovascularization of non-small-cell lung cancer via activating ERK1/2 signaling pathway [0.03%]
肿瘤相关钙信号转导蛋白2通过激活ERK1 / 2信号通路调节非小细胞肺癌的新生血管生成
Xiaobin Guo,Xiaoming Zhu,Limin Zhao et al.
Xiaobin Guo et al.
Lung cancer, especially the non-small-cell lung cancer, is a highly aggressive vascular cancer with excessively activated signaling pathways. Tumor-associated calcium signal transducer 2, also known as trop2, was identified to be correlated...
Demethoxycurcumin inhibited human epithelia ovarian cancer cells' growth via up-regulating miR-551a [0.03%]
姜黄素类似物逆没药烯酮通过上调miR-551a抑制人源卵巢癌细胞的增殖
Zhenhua Du,Xianqun Sha
Zhenhua Du
Curcumin is a natural agent that has ability to dampen tumor cells' growth. However, the natural form of curcumin is prone to degrade and unstable in vitro. Here, we demonstrated that demethoxycurcumin (a curcumin-related demethoxy compound...
MicroRNA-590-3p promotes cell proliferation and invasion by targeting inositol polyphosphate 4-phosphatase type II in human prostate cancer cells [0.03%]
microRNA-590-3p通过靶向肌醇多磷酸4-磷酸酶II促进人前列腺癌细胞增殖和侵袭
Haiwen Chen,Qidong Luo,Hongliang Li
Haiwen Chen
Inositol polyphosphate 4-phosphatase type II emerges as a tumor suppressor in prostate cancer, and its loss of expression is associated with poor prognosis for prostate cancer. However, the mechanism of downregulation of inositol polyphosph...
Computational and mechanistic studies on the effect of galactoxyloglucan: Imatinib nanoconjugate in imatinib resistant K562 cells [0.03%]
计算和机理研究：半乳糖木糖葡聚糖-伊马替尼纳米缀合物对伊马替尼耐药K562细胞的影响
Alphy Rose James,B S Unnikrishnan,R Priya et al.
Alphy Rose James et al.
Imatinib mesylate, a BCR/ABL fusion protein inhibitor, is the first-line treatment against chronic myelogenous leukemia. In spite of its advantageous viewpoints, imatinib still has genuine impediments like undesirable side effects and tumor...
Functional interaction of fibroblast growth factor 8b and androgen in prostate cancer cell proliferation [0.03%]
成纤维细胞生长因子8b与雄激素在前列腺癌细胞增殖中的功能相互作用关系研究
Wen-Jun Xiao,Gui-Ming Zhang,Ding-Wei Ye
Wen-Jun Xiao
Fibroblast growth factor 8b and androgen play important roles in cell proliferation of prostate cancer. We investigated the effects of fibroblast growth factor 8b and androgen on the proliferation of prostate cell lines and the correspondin...
Expression and prognostic value of soluble CD97 and its ligand CD55 in intrahepatic cholangiocarcinoma [0.03%]
可溶性CD97及其配体CD55在肝内胆管癌中的表达及预后价值
Ze-Wu Meng,Min-Chao Liu,Hai-Jie Hong et al.
Ze-Wu Meng et al.
The incidence rate of intrahepatic cholangiocarcinoma is rising, and treatment options are limited. Therefore, new biological markers of intrahepatic cholangiocarcinoma are needed. Immunohistochemistry and enzyme-linked immunosorbent assay ...
Coactivator-associated arginine methyltransferase 1 promotes cell growth and is targeted by microRNA-195-5p in human colorectal cancer [0.03%]
共激活物相关精氨酸甲基转移酶1促进细胞增殖并通过微小RNA-195-5p在人类结直肠癌中被靶向作用
Meifeng Zhang,Wei Wu,Ming Gao et al.
Meifeng Zhang et al.
The pathogenesis of colorectal cancer remains poorly understood. Here, we show that coactivator-associated arginine methyltransferase 1 is frequently upregulated in colorectal cancer tissues and promotes cell growth in vitro and in vivo. Us...
N6-Isopentenyladenosine promoted HeLa cell apoptosis through inhibitions of AKT and transforming growth factor β-activated kinase 1 activation [0.03%]
N6-异戊烯腺苷通过抑制AKT和转化生长因子β激活激酶1的活化促进HeLa细胞凋亡
Miao Li,Yonghao Qi,Jing Wei et al.
Miao Li et al.
N6-Isopentenyladenosine, a member of the family of plant hormones, possesses anti-cancer activities on a number of cancer cell lines. However, its mode of action in cervical cancer cell remains poorly understood. Our computational docking s...
Ioannis A Voutsadakis
Ioannis A Voutsadakis
Proteasome is a multi-protein organelle that participates in cellular proteostasis by destroying damaged or short-lived proteins in an organized manner guided by the ubiquitination signal. By being in a central place in the cellular protein...
Special AT-rich sequence binding protein 1 promotes tumor growth and metastasis of esophageal squamous cell carcinoma [0.03%]
特殊AT富集序列结合蛋白1促进食管鳞癌的生长和转移
Jun Ma,Kaiming Wu,Zhenxian Zhao et al.
Jun Ma et al.
Esophageal squamous cell carcinoma is one of the most aggressive malignancies worldwide. Special AT-rich sequence binding protein 1 is a nuclear matrix attachment region binding protein which participates in higher order chromatin organizat...