Inhibition of microRNA-21 via locked nucleic acid-anti-miR suppressed metastatic features of colorectal cancer cells through modulation of programmed cell death 4 [0.03%]
锁定核酸-反miR抑制microRNA-21通过调节程序性细胞死亡4来抑制结直肠癌细胞的转移特征
Reza Nedaeinia,Mohammadreza Sharifi,Amir Avan et al.
Reza Nedaeinia et al.
Colorectal cancer is among the most lethal of malignancies, due to its propensity to metastatic spread and multifactorial-chemoresistance. The latter property supports the need to identify novel therapeutic approaches for the treatment of c...
High expression of G-protein signaling modulator 2 in hepatocellular carcinoma facilitates tumor growth and metastasis by activating the PI3K/AKT signaling pathway [0.03%]
G蛋白信号传导调节剂2在肝癌中高表达通过激活PI3K/AKT信号通路促进肿瘤生长和转移
Xiao-Qin He,Yue-Feng Zhang,Jia-Jun Yu et al.
Xiao-Qin He et al.
The aim of this study was to investigate the role of G-protein signaling modulator 2 in the carcinogenesis and progression of hepatocellular carcinoma. We previously showed that G-protein signaling modulator 2 was upregulated in hepatitis B...
EMP2 re-expression inhibits growth and enhances radiosensitivity in nasopharyngeal carcinoma [0.03%]
EMP2再表达抑制鼻咽癌增殖并增强放射敏感性
Mei Tang,Ru-Yan Liu,Cong Zhou et al.
Mei Tang et al.
Although radiation therapy is the primary treatment for nasopharyngeal carcinoma, radioresistance remains a major obstacle to successful treatment in many cases, and the exact underlying molecular mechanisms are still ill-defined. EMP2, epi...
Comparative proteomics-network analysis of proteins responsible for ursolic acid-induced cytotoxicity in colorectal cancer cells [0.03%]
山柰酚通过WNT/β-catenin信号通路抑制结直肠癌细胞干性相关的蛋白质组学及网络分析
Qiaoyan Cai,Jing Lin,Ling Zhang et al.
Qiaoyan Cai et al.
Ursolic acid is a key active compound present in many medicinal herbs that have been widely used in traditional Chinese medicine for the clinical treatment of various cancers. However, the precise mechanisms of its antitumor activity have b...
Colorectal polypoid lesions and expression of vascular endothelial growth factor in a consecutive series of endoscopic and surgical patients [0.03%]
连续内镜和外科患者的结直肠腺瘤性病变与血管内皮生长因子表达的关系研究
Cesare Ruffolo,Luisa Toffolatti,Fabio Canal et al.
Cesare Ruffolo et al.
Colorectal cancer incidence in patients undergoing screening protocols is decreasing because of the higher rate of discovered preneoplastic colonic lesions; however, adenomatous polyps may not always be removable endoscopically and surgery ...
Magnetic resonance imaging tumor regression shrinkage patterns after neoadjuvant chemotherapy in patients with locally advanced breast cancer: Correlation with tumor biological subtypes and pathological response after therapy [0.03%]
新辅助化疗后局部晚期乳腺癌患者肿瘤的磁共振成像退缩模式与生物亚型及病理反应的相关性研究
Laura Ballesio,Silvia Gigli,Francesca Di Pastena et al.
Laura Ballesio et al.
The objective of this study is to analyze magnetic resonance imaging shrinkage pattern of tumor regression after neoadjuvant chemotherapy and to evaluate its relationship with biological subtypes and pathological response. We reviewed the m...
Crocodile choline from Crocodylus siamensis induces apoptosis of human gastric cancer [0.03%]
暹罗鳄源短链神经酰胺对人胃癌细胞的诱导凋亡作用
Xiao-Mei Mao,Qi-Rui Fu,Hua-Liang Li et al.
Xiao-Mei Mao et al.
Crocodile choline, an active compound isolated from Crocodylus siamensis, was found to exert potent anti-cancer activities against human gastric cancer cells in vitro and in vivo. Our study revealed that crocodile choline led to cell cycle ...
The role of estradiol metabolism in urogenital schistosomiasis-induced bladder cancer [0.03%]
雌二醇代谢在尿生生殖期血吸虫病引起的膀胱癌中的作用
Nuno Vale,Maria J Gouveia,Gabriel Rinaldi et al.
Nuno Vale et al.
Urogenital schistosomiasis is a neglected tropical disease that can lead to bladder cancer. How urogenital schistosomiasis induces carcinogenesis remains unclear, although there is evidence that the human blood fluke Schistosoma haematobium...
Surface-bound galectin-4 regulates gene transcription and secretion of chemokines in human colorectal cancer cell lines [0.03%]
人结直肠癌细胞系中的膜结合型半乳糖凝集素-4调节基因转录和分泌细胞趋化因子
U Subrahmanyeswara Rao,Prema S Rao
U Subrahmanyeswara Rao
One long-term complication of chronic intestinal inflammation is the development of colorectal cancer. However, the mechanisms linking inflammation to the colorectal tumorigenesis are poorly defined. Previously, we have demonstrated that ga...
Mitochondrial DNA alteration in primary and metastatic colorectal cancer: Different frequency and association with selected clinicopathological and molecular markers [0.03%]
原发和转移性结直肠癌中线粒体DNA改变的发生频率及其与选定临床病理及分子标志物的关系不同
Britta Kleist,Thuja Meurer,Micaela Poetsch
Britta Kleist
This study attempts to determine whether primary tumor tissue could reliably represent metastatic colorectal cancer in therapy-guiding analysis of mitochondrial microsatellite instability. Therefore, we investigated the concordance of micro...