Staurosporine suppresses survival of HepG2 cancer cells through Omi/HtrA2-mediated inhibition of PI3K/Akt signaling pathway [0.03%]
鱼藤酮通过Omi/HtrA2介导的PI3K/Akt信号转导通路抑制HepG2癌细胞的增殖和存活
Youming Ding,Bin Wang,Xiaoyan Chen et al.
Youming Ding et al.
Staurosporine, which is an inhibitor of a broad spectrum of protein kinases, has shown cytotoxicity on several human cancer cells. However, the underlying mechanism is not well understood. In this study, we examined whether and how this com...
Mortalin overexpression predicts poor prognosis in early stage of non-small cell lung cancer [0.03%]
Mortalin过表达预示非小细胞肺癌早期阶段的不良预后
Jie Sun,Shuan-Long Che,Jun-Jie Piao et al.
Jie Sun et al.
Mortalin is a member of the heat shock protein 70 family, which is involved in multiple cellular processes and may play key roles in promoting carcinogenesis. This study attempted to identify the clinical consequences of Mortalin overexpres...
Methylomics of breast cancer: Seeking epimarkers in peripheral blood of young subjects [0.03%]
乳腺癌的甲基化组研究：在年轻患者外周血中寻找表观遗传标志物
Golnaz Khakpour,Mehrdad Noruzinia,Pantea Izadi et al.
Golnaz Khakpour et al.
Critical roles of epigenomic alterations in the pathogenesis of breast cancer have recently seized great attentions toward finding epimarkers in either non-invasive or semi-non-invasive samples as well as peripheral blood. In this way, meth...
Increased efficacy of a dendritic cell-based therapeutic cancer vaccine with adenosine receptor antagonist and CD73 inhibitor [0.03%]
兼用腺苷受体拮抗剂和CD73抑制剂增强树突状细胞治疗性癌症疫苗的效果
Samaneh Arab,Nasim Kheshtchin,Maryam Ajami et al.
Samaneh Arab et al.
Dendritic cells are important in initiating immune responses; therefore, a range of dendritic cell-based approaches have been established to induce immune response against cancer cells. However, the presence of immunosuppressive mediators s...
Upregulation of long noncoding RNA zinc finger antisense 1 enhances epithelial-mesenchymal transition in vitro and predicts poor prognosis in glioma [0.03%]
长非编码RNA锌指反义1的上调通过体外实验增强上皮间质转化并预测胶质瘤预后不良
Qiao-Li Lv,Shu-Hui Chen,Xue Zhang et al.
Qiao-Li Lv et al.
Increasing evidence indicates that long noncoding RNAs play important roles in development and progression of various cancers. Zinc finger antisense 1 is a novel long noncoding RNA whose clinical significance, biological function, and under...
SLCO1B3 screening in colorectal cancer patients using High-Resolution Melting Analysis method and immunohistochemistry [0.03%]
采用高分辨率熔解分析和免疫组化方法筛选结直肠癌患者SLCO1B3基因型分布及表达差异
Lampri Evangeli,Sainis Ioannis,Kounnis Valentinos et al.
Lampri Evangeli et al.
Personalized medicine has made some major advances in colorectal cancer, but new biomarkers still remain a hot issue as an emerging tool with potential prognostic and therapeutic potential. We investigated for SLCO1B3 gene alterations and p...
LAMP3 expression correlated with poor clinical outcome in human ovarian cancer [0.03%]
LAMP3表达与人类卵巢癌不良临床结局相关
Di Wang,Xuemin Cao,Yuquan Zhang et al.
Di Wang et al.
Lysosome-associated membrane protein 3 belongs to the lysosome-associated membrane glycoprotein family, which is associated with lymph node, metastasis, poor overall survival, and resistance to chemotherapy and radiotherapy. Epithelial ovar...
Efficient killing of radioresistant breast cancer cells by cytokine-induced killer cells [0.03%]
细胞因子诱导的杀手细胞高效杀伤放疗抵抗性乳腺癌细胞
Qingming Guo,Danni Zhu,Xiaocui Bu et al.
Qingming Guo et al.
Recurrence of breast cancer after radiotherapy may be partly explained by the presence of radioresistant cells. Thus, it would be desirable to develop an effective therapy against radioresistant cells. In this study, we demonstrated the int...
ADAM-17/FHL2 colocalisation suggests interaction and role of these proteins in colorectal cancer [0.03%]
ADAM-17/FHL2 共定位提示这两种蛋白质在结直肠癌中的相互作用及功能
Laurine Verset,Joke Tommelein,Christine Decaestecker et al.
Laurine Verset et al.
FHL2 is a multifunctional scaffolding protein; its expression is associated with poor prognosis in colorectal cancer. ADAM-17 is a metalloprotease implicated in ectodomain shedding. FHL2 regulates ADAM-17 plasma membrane localisation, and F...
The distribution and potential prognostic value of SMAD protein expression in chronic lymphocytic leukemia [0.03%]
SMAD蛋白在慢性淋巴细胞白血病中的表达及预后价值分析
Magdalena Witkowska,Agata Majchrzak,Barbara Cebula-Obrzut et al.
Magdalena Witkowska et al.
The SMAD proteins are responsible for transducing signals from activated transforming growth factor-beta. This is the first study assessing the expression of SMAD-1/8, SMAD-2/3, SMAD-4, and SMAD-7 in chronic lymphocytic leukemia cells with ...