Crocetin shifts autophagic cell survival to death of breast cancer cells in chemotherapy [0.03%]
金丝桃素使乳腺癌细胞从化疗的自噬性细胞存活转向死亡
Ailian Zhang,Jincheng Li
Ailian Zhang
The chemotherapy with fluorouracil is not always effective, in which some breast cancer cells may survive the fluorouracil treatment through enhanced autophagy. Crocetin is the major constituent of saffron, a Chinese traditional herb, which...
Effect of EBI3 on radiation-induced immunosuppression of cervical cancer HeLa cells by regulating Treg cells through PD-1/PD-L1 pathway [0.03%]
EBI3通过PD-1/PD-L1信号通路调节Treg细胞抑制宫颈癌HeLa细胞放疗诱导的免疫抑制的作用研究
Song-An Zhang,Hu-Er-Xi-Dan Niyazi,Wen Hong et al.
Song-An Zhang et al.
This study aimed to investigate the effect of EBI3 on radiation-induced immunosuppression of cervical cancer HeLa cells by regulating Treg cells through PD-1/PD-L1 signaling pathway. A total of 43 adult female Wistar rats were selected and ...
Nigericin decreases the viability of multidrug-resistant cancer cells and lung tumorspheres and potentiates the effects of cardiac glycosides [0.03%]
尼日青素可降低多药耐药癌细胞和肺癌肿瘤球体的存活率并增强强心苷的作用
Juan Sebastian Yakisich,Neelam Azad,Vivek Kaushik et al.
Juan Sebastian Yakisich et al.
Multiple factors including tumor heterogeneity and intrinsic or acquired resistance have been associated with drug resistance in lung cancer. Increased stemness and the plasticity of cancer cells have been identified as important mechanisms...
Suppression of p53-inducible gene 3 is significant for glioblastoma progression and predicts poor patient prognosis [0.03%]
p53诱导基因3的抑制对胶质母细胞瘤进展具有重要意义并预示患者预后不良
Jishu Quan,Yong Li,Meihua Jin et al.
Jishu Quan et al.
Glioblastoma is the most malignant and invasive brain tumor with extremely poor prognosis. p53-inducible gene 3, a downstream molecule of the tumor suppressor p53, has been found involved in apoptosis and oxidative stress response. However,...
Intracellular calcium promotes radioresistance of non-small cell lung cancer A549 cells through activating Akt signaling [0.03%]
胞内钙促进非小细胞肺癌A549细胞放射抵抗通过激活Akt信号通路研究
Yiling Wang,Jiantao He,Shenghui Zhang et al.
Yiling Wang et al.
Radiotherapy is a major therapeutic approach in non-small cell lung cancer but is restricted by radioresistance. Although Akt signaling promotes radioresistance in non-small cell lung cancer, it is not well understood how Akt signaling is a...
gamma-H2AX: Can it be established as a classical cancer prognostic factor? [0.03%]
γ-H2AX能成为经典的癌症预后因素吗？
Viktoria-Varvara Palla,Georgios Karaolanis,Ioannis Katafigiotis et al.
Viktoria-Varvara Palla et al.
Double-strand breaks are among the first procedures taking place in cancer formation and progression as a result of endogenic and exogenic factors. The histone variant H2AX undergoes phosphorylation at serine 139 due to double-strand breaks...
PVT1 affects growth of glioma microvascular endothelial cells by negatively regulating miR-186 [0.03%]
PVT1通过负向调控miR-186影响胶质瘤微血管内皮细胞的生长
Yawen Ma,Ping Wang,Yixue Xue et al.
Yawen Ma et al.
Vigorous angiogenesis is one of the reasons for the poor prognosis of glioma. A number of studies have shown that long non-coding RNA can affect a variety of biological behaviors of tumors. However, the influence of long non-coding RNAs on ...
Mammalian target of rapamycin inhibitors, temsirolimus and torin 1, attenuate stemness-associated properties and expression of mesenchymal markers promoted by phorbol-myristate-acetate and oncostatin-M in glioblastoma cells [0.03%]
雷帕霉素哺乳动物靶蛋白抑制剂（坦西罗莫司和托瑞米芬）可减弱原发性胶质母细胞瘤肿瘤干细胞特性及相关间质标志物的表达
Goparaju Chandrika,Kumar Natesh,Deepak Ranade et al.
Goparaju Chandrika et al.
The phosphatidylinositol 3-kinase/Akt/mammalian target of rapamycin signaling pathway is crucial for tumor survival, proliferation, and progression, making it an attractive target for therapeutic intervention. In glioblastoma, activated mam...
Li Ding,Jie Ni,Fan Yang et al.
Li Ding et al.
MicroRNAs are small nonprotein-encoding RNAs ranging from 18 to 25 nucleotides in size and regulate multiple biological pathways via directly targeting a variety of associated genes in cancers. MicroRNA-27b is a highly conserved MicroRNA th...
SF3B4 is decreased in pancreatic cancer and inhibits the growth and migration of cancer cells [0.03%]
SF3B4在胰腺癌中表达降低并能够抑制癌细胞增殖和迁移
Wentao Zhou,Ning Ma,Hao Jiang et al.
Wentao Zhou et al.
Splicing factor 3b subunit 4, a critical component of pre-message RNA splicing complex, has been reported to play an important part in the tumorigenesis. However, the expression pattern and biological role of splicing factor 3b subunit 4 in...