CT imaging phenotypes linked to CA125 and HE4 biomarkers are highly predictive in discriminating between hereditary and sporadic ovarian cancer patients [0.03%]
与CA125和HE4生物标志物相关的CT影像表型在区分遗传性和散发性卵巢癌患者方面具有很高的预测价值
Lucia Manganaro,Veronica Celli,Valentina Viggiani et al.
Lucia Manganaro et al.
Background: Hereditary ovarian cancers (HOC) represent about 23% of ovarian cancer (OC) cases: they are most frequently related to germline mutations in the BRCA genes. ...
Radhika Manukonda,Jyothi Attem,Vengala Rao Yenuganti et al.
Radhika Manukonda et al.
Exosomes are a subgroup of membrane-bound extracellular vesicles secreted by all cell types and present virtually in all biological fluids. The composition of exosomes in the same cell type varies in healthy and disease conditions. Hence, e...
MicroRNA-99b-5p targets mTOR/AR axis, induces autophagy and inhibits prostate cancer cell proliferation [0.03%]
miR-99b-5p靶向mTOR/AR轴诱导自噬并抑制前列腺癌细胞增殖
Suryakant Niture,Lucas Tricoli,Qi Qi et al.
Suryakant Niture et al.
Objectives: MicroRNAs (miRNAs) are the small non-coding regulatory RNA molecules involved in gene regulation via base-pairing with complementary sequences in mRNAs. The dysregulation of specific miRNAs, such as miR-99b-5p...
β-Catenin is reduced in membranes of human prolactinoma cells and it is inhibited by temozolomide in prolactin secreting tumor models [0.03%]
膜黏连蛋白在人泌乳素瘤细胞中减少，并可通过替莫唑胺抑制泌乳素分泌肿瘤模型中的Wnt/β-联环蛋白信号通路
Gianina Demarchi,Sofía Valla,Sofía Perrone et al.
Gianina Demarchi et al.
Introduction: Prolactinomas are the most frequent pituitary tumor subtype. Despite most of them respond to medical treatment, a proportion are resistant and become a challenge in clinical management. Wnt/β-Catenin pathwa...
β-catenin plus PROX1 immunostaining stratifies disease progression and patient survival in neoadjuvant-treated pancreatic cancer [0.03%]
β-catenin和PROX1免疫组化分层新辅助治疗后的胰腺癌患者预后及生存率
Annika Eurola,Ari Ristimäki,Harri Mustonen et al.
Annika Eurola et al.
Background: Wnt/β-catenin signaling is a highly conserved signaling pathway that regulates the transcription factor PROX1. The role of β-catenin and PROX1 in pancreatic cancer is ambiguous, as some studies have associat...
Bithiophene derivative induced apoptosis and suppression of Akt pathway in mouse leukemic model [0.03%]
一种联苯衍生物诱导的小鼠白血病模型的凋亡及其对Akt通路的抑制作用
Ali Samy Algharib,Gamila Mohamed-Labib Shanab,Abdel-Rahman Badr Abdel-Ghaffar et al.
Ali Samy Algharib et al.
Background: Bithiophene derivatives show a promising anti-cancer potential. We previously showed that Bithienyl Fluorobenzamidine (BFB) has an anti-proliferative effect against several leukemia cell lines. Acute myeloid l...
Tumor-associated CD3- and CD8-positive immune cells in colorectal cancer: The additional prognostic value of CD8+-to-CD3+ ratio remains debatable [0.03%]
结直肠癌肿瘤相关CD3和CD8阳性免疫细胞：CD8+与CD3+比值的预后价值仍存争议
Jussi Kasurinen,Jaana Hagström,Tuomas Kaprio et al.
Jussi Kasurinen et al.
Background: A large number of infiltrating CD3- and CD8-positive inflammatory cells indicates an improved survival in colorectal cancer (CRC), similar to many other cancers. ...
Vitamin B12 enhances the antitumor activity of 1,25-dihydroxyvitamin D3 via activation of caspases and targeting actin cytoskeleton [0.03%]
维生素B12通过激活半胱天冬酶和靶向细胞骨架增强1,25-二羟基维生素D3的抗肿瘤活性
Manar F Atoum,Foad E Alzoughool,Zainab A Al-Mazaydeh et al.
Manar F Atoum et al.
Background: 1,25-dihydroxyvitamin D3 (1,25(OH)2D3) is an effective anticancer agent, and when combined with other agents it shows superior activities. Vitamin B12 has been shown to contribute to increasing the effectivene...
Serological cancer-associated protein biomarker levels at bowel endoscopy: Increased risk of subsequent primary malignancy [0.03%]
结肠镜检查中血清肿瘤相关蛋白生物标志物水平升高与后续原发癌风险增加有关
Thomas B Piper,Hans J Nielsen,Ib Jarle Christensen
Thomas B Piper
Background: It was previously shown in three subpopulations that subjects not identified with colorectal cancer (CRC) at bowel endoscopy, but with increased serological cancer-associated protein biomarker levels had an in...
Retraction notice regarding several articles published in Tumor Biology [0.03%]
关于《肿瘤生物学》杂志上数篇已发表文章的撤稿通知
The publisher and the Editor-in-Chief, in consultation with former publisher of Tumor Biology, retract a total of 15 articles from the journals' online catalog. The articles were published in different issues of the journal during the perio...