Clinical significance of TP53 alterations in advanced NSCLC patients treated with EGFR, ALK and ROS1 tyrosine kinase inhibitors: An update [0.03%]
TP53改变在EGFR、ALK和ROS1酪氨酸激酶抑制剂治疗的晚期非小细胞肺癌患者中的临床意义：更新版
Joanna Moes-Sosnowska,Adam Szpechcinski,Joanna Chorostowska-Wynimko
Joanna Moes-Sosnowska
The development of targeted therapies for non-small cell lung cancer (NSCLC), such as the epidermal growth factor receptor (EGFR), anaplastic lymphoma receptor tyrosine kinase (ALK), and ROS proto-oncogene 1 (ROS1), has improved patients' p...
Prognostic value of tumor markers ProGRP, NSE and CYFRA 21-1 in patients with small cell lung cancer and chemotherapy-induced remission [0.03%]
小细胞肺癌患者的肿瘤标志物ProGRP、NSE和CYFRA 21-1的预后价值及化疗诱导缓解期的意义
Thomas Muley,Felix J Herth,Claus Peter Heussel et al.
Thomas Muley et al.
Background: Despite successful response to first line therapy, patients with small-cell lung cancer (SCLC) often suffer from early relapses and disease progression. ...
Abel J Bronkhorst,Stefan Holdenrieder
Abel J Bronkhorst
The cumulative pool of cell-free DNA (cfDNA) molecules within bodily fluids represents a highly dense and multidimensional information repository. This "biological mirror" provides real-time insights into the composition, function, and dyna...
CYFRA 21-1, CA 125 and CEA provide additional prognostic value in NSCLC patients with stable disease at first CT scan [0.03%]
基线CT扫描结果为疾病稳定的肺鳞癌和非鳞癌患者中，细胞角蛋白19片段(CYFRA 21-1)、癌抗原CA125和癌胚抗原CEA提供预后价值
Thomas Muley,Mark A Schneider,Michael Meister et al.
Thomas Muley et al.
Background: Serum tumor markers (STM) may complement imaging and provide additional clinical information for patients with non-small cell lung cancer (NSCLC). ...
Induction of epithelial-mesenchymal transition in thyroid follicular cells is associated with cell adhesion alterations and low-dose hyper-radiosensitivity [0.03%]
甲状腺滤泡细胞上皮间质转化与细胞粘附改变及低剂量超辐射敏感性有关
Ankit Mathur,Vijayakumar Chinnadurai,Param Jit Singh Bhalla et al.
Ankit Mathur et al.
Background: Epithelial-mesenchymal transition (EMT) is associated with altered cellular adhesion. We previously demonstrated that cellular adhesion influences Low-dose Hyper-Radiosensitivity (HRS) in a variety of tumor ce...
Suppression of Krüppel-like factor 5 basal expression by CREB1 binding to far distal element [0.03%]
CREB1结合远端元件抑制Krüppel样因子5的基线表达
Nozomi Mihara,Kazushi Imai
Nozomi Mihara
Background: Krüppel-like factor 5 (KLF5) is a transcription factor regulating the proliferation and differentiation of epithelial cells, and its uncontrolled expression is closely associated with carcinoma progression. S...
Small-interfering RNA targeting proprotein convertase subtilisin/kexin type 9 might promote fatty liver disease and hepatocellular carcinoma through upregulation of CD36 [0.03%]
针对PCSK9的siRNA可能通过上调CD36促进脂肪肝病和肝细胞癌
Frank S Fan
Frank S Fan
Proprotein convertase subtilisin/kexin type 9 (PCSK9) binds to low-density lipoprotein (LDL) receptor and fatty acid translocase CD36, inducing lysosomal degradation of these two receptors in the liver cells. Both monoclonal antibody (mAb) ...
Identification of HPV16 positive cervical cancer subsets characterized by divergent immune and oncogenic phenotypes with potential implications for immunotherapy [0.03%]
识别HPV16阳性宫颈癌亚型及其免疫和致癌性表型的潜在治疗意义
Abhisikta Ghosh,Arnab Ghosh,Abarna Sinha et al.
Abhisikta Ghosh et al.
Background: Cervical cancers (CaCx), like many other cancer types, portray high molecular heterogeneity that affects response to therapy, including immunotherapy. In India and other developing countries, CaCx mortality ra...
Co-expression of galectin-3 and vimentin in triple negative breast cancer cells promotes tumor progression, metastasis and survival [0.03%]
半乳糖凝集素-3和波形蛋白在三阴性乳腺癌细胞中的共表达促进肿瘤进展、转移及存活
T Jeethy Ram,Asha Lekshmi,Pramod Darvin et al.
T Jeethy Ram et al.
Background: Lack of druggable targets and complex expression heterogeneity of known targets is common among TNBC subtypes. An enhanced expression of galectin-3 in TNBCs has already been documented. We have observed a tumo...