Role of RUNX2 transcription factor in epithelial mesenchymal transition in non-small cell lung cancer lung cancer: Epigenetic control of the RUNX2 P1 promoter [0.03%]
RUNX2转录因子在非小细胞肺癌上皮间质转化中的作用：RUNX2 P1启动子的表观遗传调控
Angélica María Herreño,Andrea Carolina Ramírez,Viviana Paola Chaparro et al.
Angélica María Herreño et al.
Lung cancer has a high mortality rate in men and women worldwide. Approximately 15% of diagnosed patients with this type of cancer do not exceed the 5-year survival rate. Unfortunately, diagnosis is established in advanced stages, where oth...
Chieko Kitamura,Hirofumi Sonoda,Hiroaki Nozawa et al.
Chieko Kitamura et al.
Although lysophospholipids are known to play an important role in the development and progression of several kinds of cancers, their role in human colorectal cancer is as yet unclear. In this study, we aim to investigate lysophospholipid le...
Radotinib inhibits mitosis entry in acute myeloid leukemia cells via suppression of Aurora kinase A expression [0.03%]
拉多替尼通过抑制Aurora激酶A的表达阻滞急性髓系白血病细胞进入有丝分裂
Sook-Kyoung Heo,Eui-Kyu Noh,Yoo Kyung Jeong et al.
Sook-Kyoung Heo et al.
Aurora kinases play critical roles in regulating several processes pivotal for mitosis. Radotinib, which is approved in South Korea as a second-line treatment for chronic myeloid leukemia, inhibits the tyrosine kinase BCR-ABL and platelet-d...
Mesenchymal stem cells targeting PI3K/AKT pathway in leukemic model [0.03%]
针对白血病模型中PI3K/AKT信号途径的间质干细胞
Esraa S A Ahmed,Neamat H Ahmed,Amina M Medhat et al.
Esraa S A Ahmed et al.
Mesenchymal stem cells have therapeutic properties that are related to their potentials for trans-differentiation, immunomodulation, anti-inflammatory, inhibitory effect on tumor proliferation, and induction of apoptosis. This study was per...
Common matrix metalloproteinase-2 gene variants and altered susceptibility to breast cancer and associated features in Tunisian women [0.03%]
基质金属蛋白酶-2基因多态性与突变对突尼斯妇女乳腺癌易感性和相关特征的影响
Azza F Habel,Rabeb M Ghali,Hanen Bouaziz et al.
Azza F Habel et al.
A role for matrix metalloproteinase polymorphisms in breast cancer development and progression was proposed, but with inconclusive results. We assessed the relation of matrix metalloproteinase-2 variants with breast cancer and related pheno...
Association of expression of inflammatory response genes and DNA repair genes in colorectal carcinoma [0.03%]
结直肠癌中炎症反应基因和DNA修复基因表达的关联性研究
Demétrius Eduardo Germini,Maria Isete Fares Franco,Fernando Luiz Affonso Fonseca et al.
Demétrius Eduardo Germini et al.
Inflammation is an important etiological factor of colorectal carcinoma and may be related to colorectal carcinoma growth and proliferation. This study aimed to verify whether the presence of chronic inflammation represented by tumor necros...
CXC chemokine ligand 1 mediates adiponectin-induced angiogenesis in ovarian cancer [0.03%]
血管生成在家型卵泡刺激素诱导卵巢癌细胞转移中的作用及机制研究
Yung-Taek Ouh,Hyun Woong Cho,Jae Kwan Lee et al.
Yung-Taek Ouh et al.
Objectives: Adiponectin is a cytokine secreted from adipose tissue that regulates energy homeostasis, inflammation, and cell proliferation. Obesity is associated with increased risk of various cancers, including ovarian c...
The metabolic milieu in melanoma: Role of immune suppression by CD73/adenosine [0.03%]
黑色素瘤中的代谢微环境：CD73/腺苷的免疫抑制作用
Anna Passarelli,Marco Tucci,Francesco Mannavola et al.
Anna Passarelli et al.
The mechanisms leading to immune escape of melanoma have been largely investigated in relation to its tumour immunogenicity and features of inflamed microenvironment that promote the immune suppression during the disease progression. These ...
Clinical-pathological characteristics and short-term follow-up associated with proliferation, apoptosis and angiogenesis in a prospective cohort of patients with colorectal tumours [0.03%]
与增殖、凋亡和新生血管形成有关的临床病理特征及短期随访结果——结直肠肿瘤前瞻性队列研究
Maximino Redondo,Cristina Abitei,Teresa Téllez et al.
Maximino Redondo et al.
We investigate the clinical and pathological features related to variations in colorectal tumour apoptosis, proliferation and angiogenesis and the influence of the latter in short-term mortality (2 years); 551 tumour samples from a prospect...