The association of a single-nucleotide variant in the microRNA-146a with advanced colorectal cancer prognosis [0.03%]
微核糖核酸-146a单核苷酸多态性与晚期结直肠癌预后相关性研究
Jéssica Silva Dos Santos,Gabriella Lucatto Zunta,Amanda Binatto Negrini et al.
Jéssica Silva Dos Santos et al.
The aim of this study was to evaluate the association of single-nucleotide variant n.60G>C (rs2910164) of microRNA (miR)-146a, related to suppressing of BRCA1/2 DNA repair protein, with the risk and survival of colorectal cancer patients, a...
Evaluation of cytotoxic and anticancer effect of Orobanche crenata methanolic extract on cancer cell lines [0.03%]
奥罗巴纳提取物的细胞毒性和抗癌效果评估研究
Marwa Ga Hegazy,Amal M Imam,Bassem E Abdelghany
Marwa Ga Hegazy
We aimed to assess the antitumor activity of Orobanche crenata methanolic extract and evaluate its cytotoxic effect on different cancer cell lines to develop an effective natural anticancer drug. Components of O. crenata methanolic extract ...
Overexpression of NEIL3 associated with altered genome and poor survival in selected types of human cancer [0.03%]
NEIL3过表达与人类某些类型癌症的异常基因组和较差预后相关
Oanh Tn Tran,Serkalem Tadesse,Christopher Chu et al.
Oanh Tn Tran et al.
Base excision repair, which is initiated by the DNA N-glycosylase proteins, is the frontline for repairing potentially mutagenic DNA base damage. Several base excision repair genes are deregulated in cancer and affect cellular outcomes to c...
Increased circulating tumor DNA as a noninvasive biomarker of early treatment response in patients with metastatic ovarian carcinoma: A pilot study [0.03%]
循环肿瘤DNA作为转移性卵巢癌患者早期治疗反应的非侵入性生物标志物：一项试点研究
Mariana Cartaxo Alves,Fernando Luiz Affonso Fonseca,Alayne Magalhães Trindade Domingues Yamada et al.
Mariana Cartaxo Alves et al.
Detection of circulating tumor DNA is a new noninvasive technique with potential roles in diagnostic, follow-up, and prognostic evaluation of patients with many types of solid tumors. We aimed to evaluate the role of circulating tumor DNA i...
Knockdown of A-kinase anchor protein 4 inhibits proliferation of triple-negative breast cancer cells in vitro and in vivo [0.03%]
下调A kinase anchor protein 4对三阴性乳腺癌细胞的抑制作用
Nirmala Jagadish,Sonika Devi,Namita Gupta et al.
Nirmala Jagadish et al.
Triple-negative breast cancers are the most aggressive subtypes with poor prognosis due to lack of targeted cancer therapy. Recently, we reported an association of A-kinase anchor protein 4 expression with various clinico-pathological param...
Comparison of methods for the isolation of cell-free DNA from cell culture supernatant [0.03%]
比较从细胞培养上清液中分离无细胞DNA的方法
Abel Jacobus Bronkhorst,Vida Ungerer,Stefan Holdenrieder
Abel Jacobus Bronkhorst
In vitro characterization of cell-free DNA using two-dimensional cell culture models is emerging as an important step toward an improved understanding of the physical and biological characteristics of cell-free DNA in human biology. However...
Polo-like kinase 1 as a promising diagnostic biomarker and potential therapeutic target for hepatocellular carcinoma [0.03%]
polo样激酶1作为肝细胞癌诊断生物标志物及潜在治疗靶点的潜力
Eman H Yousef,Mohamed E El-Mesery,Maha R Habeeb et al.
Eman H Yousef et al.
Hepatocellular carcinoma is a major cause of cancer mortality worldwide. The outcome of hepatocellular carcinoma depends mainly on its early diagnosis. To date, the performance of traditional biomarkers is unsatisfactory. Polo-like kinase 1...
Samarium enriches antitumor activity of ZnO nanoparticles via downregulation of CXCR4 receptor and cytochrome P450 [0.03%]
钐通过下调CXCR4受体和细胞色素P450丰富了ZnO纳米粒子的抗肿瘤活性
Asmaa I Nabeel
Asmaa I Nabeel
Cancer is the leading cause of death and exhausts human and economic resources for treatment and protection. Zinc oxide nanoparticles play an effective role in tumor treatment but with some cautions, such as overexpression of cytochrome P45...
Ian A Cree,B Iciar Indave
Ian A Cree
Cancer researchers require accurate diagnoses for the samples, cell lines, patients or populations that they study. These diagnoses are underpinned by an internationally accepted taxonomy - the World Health Organization Classification of Tu...
Antiproliferative and proapoptotic effects of Inula viscosa extract on Burkitt lymphoma cell line [0.03%]
灯心草提取物对Burkitt淋巴瘤细胞系的抗增殖和促凋亡作用
Patrizia Virdis,Rossana Migheli,Grazia Galleri et al.
Patrizia Virdis et al.
Burkitt lymphoma is a very aggressive B-cell non-Hodgkin lymphoma. Although remarkable progress has been made in the therapeutic scenario for patients with Burkitt lymphoma, search and development of new effective anticancer agents to impro...