Efficacy and Safety of Avacopan in ANCA-Associated Vasculitis: A Meta-Analysis of Randomized Controlled Trials [0.03%]
抗中性粒细胞胞浆抗体相关性血管炎患者使用艾考考皮尼的疗效和安全性：系统评价和Meta分析
Young Ho Lee,Gwan Gyu Song
Young Ho Lee
Background: Avacopan, an oral C5a receptor antagonist, has been identified as a promising glucocorticoid-sparing agent in the management of ANCA-associated vasculitis (AAV). Although individual randomized controlled trial...
3-Hydroxybutyrate Prevents Pulmonary Vein Arrhythmogenesis by Regulating Calcium/Calmodulin-Dependent Protein Kinase II Signaling and Oxidative Stress [0.03%]
3-羟基丁酸通过调节钙调神经磷酸酶II信号和氧化应激预防肺静脉心律失常
Chye-Gen Chin,Fong-Jhih Lin,Yao-Chang Chen et al.
Chye-Gen Chin et al.
Introduction Atrial fibrillation is the most common sustained cardiac arrhythmia, primarily caused by arrhythmogenic activity within the pulmonary veins (PVs). Enhanced ketone body utilization can prevent heart failure by reducing inflammat...
Heterogeneity and regulatory mechanisms of ALK-mutant and wild-type epithelial cells in non-small-cell lung cancer: Single-cell transcriptomics and chromatin accessibility [0.03%]
非小细胞肺癌中ALK突变和野生型上皮细胞的异质性和调控机制：单细胞转录组学和染色质可及性研究
Yafu Zhou,Manni Yi,Jianhua Yan et al.
Yafu Zhou et al.
Background: ALK mutations are key oncogenic drivers in non-small-cell lung cancer (NSCLC). Although ALK tyrosine kinase inhibitors (TKIs) elicit high initial response rates, relapse due to acquired resistance is common. C...
Targeting Autophagy to Restore Intestinal Integrity in Sepsis: Resveratrol's NOX1/SIRT1-Mediated Protective Effect [0.03%]
雷斯维斯特洛通过NOX1/SIRT1介导的作用恢复感染性休克肠道屏障的自噬机制研究
Wei Zhang,Jiang Yu,Zhongliang Shi et al.
Wei Zhang et al.
Introduction: One serious consequence of sepsis that has a direct impact on patient outcomes is intestinal barrier disruption brought on by sepsis. Although the polyphenolic molecule resveratrol (RE) is well-known for its...
Lu Zhang,Di Liu,Qiuyang Huang et al.
Lu Zhang et al.
Wedelolactone (WED) is a polyphenolic compound with a coumarin skeleton isolated from marigold. Despite its wide application in traditional medicine, its mechanisms of action and safety profile require further investigation. The innovation ...
Escitalopram oxalate improved insomnia by targeting SLC6A4 to regulate the hypothalamic-pituitary-adrenal axis [0.03%]
埃斯西拉普氧化物通过靶向SLC6A4调节下丘脑-垂体-肾上腺轴以改善失眠
Xin Gu,Jing An,Mingxue Zhang et al.
Xin Gu et al.
Background: Escitalopram oxalate (ESC) was extensively reported to improve insomnia in patients with depression/anxiety. The serotonin transporter gene (SLC6A4) was involved in regulating insomnia. However, it is still un...
Phytochemicals as Emerging Antiproliferative Agents in Head and Neck Cancer: Molecular Mechanisms and Therapeutic Strategies [0.03%]
植物化学物质作为头颈部癌症中新兴的抗增殖剂：分子机制和治疗策略
Livia Ramos Santiago,Estéfani Alves Asevedo,Moon Nyeo Park et al.
Livia Ramos Santiago et al.
innovative therapeutic strategies beyond conventional treatments. The increasing interest in natural and synthetic antiproliferative compounds is driven by their ability to target oncogenic pathways implicated in tumor progression, metastas...
A Network Meta-Analysis of Pharmacological Treatments for Gastric Mucosal Protection in Artificial Ulcers Following Endoscopic Submucosal Dissection (ESD) of the Stomach [0.03%]
内镜下黏膜剥离术(ESD)后人工溃疡胃粘膜保护类药物治疗的网络 Meta 分析
Zhiqun Chen,Sanhui Zhan,Haiyang Yu
Zhiqun Chen
Background: Proton pump inhibitor (PPI) monotherapy is standard for artificial ulcer healing after gastric endoscopic submucosal dissection (ESD), but evidence on the efficacy of PPI combined with gastric mucosal protecta...
The stability of drugs commonly used in intensive care units co-administered via feeding tube and its dependence on pH: An in vitro study [0.03%]
经胃管联合给药的常用药物稳定性及其与pH依赖关系的体外研究
Adriána Papiež,Pavel Suk,Radka Baránková et al.
Adriána Papiež et al.
Introduction: The administration of medication through feeding tubes (FT) represents a critical aspect of routine nursing practice. Although guidelines recommend the separate administration of medications to minimize pote...
Inhibition of the Mevalonate Pathway Targets Neuroblastoma Stem Cells [0.03%]
他莫昔芬联合维生素K2通过靶向神经母瘤干细胞发挥协同抗肿瘤作用的机制研究
Michelle V Green,Jessie L Reed,Cameron D Zielinski et al.
Michelle V Green et al.
Introduction: High-risk neuroblastoma is a difficult to treat cancer with high rates of recurrence and treatment resistance, likely driven by a population of cancer stem cells. Multiple previous studies have suggested tha...