Gene Therapy for Autism Spectrum Disorder: Preclinical Advances, Translational Barriers, and Ethical Dimensions - A Scoping Review [0.03%]
自闭症谱系障碍基因治疗的动物模型及临床转化瓶颈和伦理争议-综述文章
Ali Naderi Malek,Amir Hossein Rasoli Jokar,Patricia Prelock
Ali Naderi Malek
Background: Autism spectrum disorder (ASD) lacks disease-modifying therapies. Gene therapy offers a promising avenue to target the underlying molecular causes of ASD, particularly in monogenic or syndromic forms where sin...
Elise Bücklein-Ehlers,Manon Dubol,Birgit Derntl et al.
Elise Bücklein-Ehlers et al.
Introduction: Left-right brain asymmetry is an important feature of human neuroanatomy, with implications for cognition, behaviour, and vulnerability to mental disorders. Despite evidence for lateralized sensitivity to ho...
Implications of Cortisol in Cognitive Impairment Observed in Cancer Patients: A Systematic Review [0.03%]
皮质醇与癌症患者认知障碍的系统评价研究
Ángel Rodríguez-Ramos,Raquel Espejo-Siles,Ana Belén Castillo-Miranda et al.
Ángel Rodríguez-Ramos et al.
Introduction: Cancer-related cognitive impairment (CRCI) is a frequent adverse effect observed in patients, but the underlying mechanisms are still unclear. Cortisol has been proposed as a potential contributor to CRCI, s...
Ahmet Gürcan,Koray Başar,Sevilay Karahan
Ahmet Gürcan
Background: Anhedonia and reward processing deficits are core features of Major Depressive Disorder (MDD). However, their persistence following remission remains unclear, hindering the differentiation between state versus...
Monoamine neurotransmitters in saliva - novel biomarkers of CNS function? Peripheral biomarkers of therapeutic response/ CNS function [0.03%]
saliva 中的单胺类神经递质：新型中枢神经系统功能生物标志物？治疗反应/中枢神经系统功能的外周生物标志物
Layla Bleibel,Rami Altabbouche,Bojana Vuksan et al.
Layla Bleibel et al.
Monoamine neurotransmitters, including catecholamines (i.e., norepinephrine, epinephrine, and dopamine), and the indolamine serotonin play important roles in signaling in the central and peripheral nervous systems. Alterations in neurotrans...
Autonomic Nervous System Regulation in Women: Electrophysiological Signatures of Stress Reactivity Across the Female Lifespan [0.03%]
女性自主神经调节：一生应激反应的电生理标志
Hasan Kazdağli,Tülin Altinoluk
Hasan Kazdağli
Background: Women exhibit distinct stress-response patterns shaped by dynamic interactions between ovarian hormones, the autonomic nervous system (ANS), and cortical stress-processing circuits. Across the female lifespan,...
Annelies Dellink,Jean-Baptiste Belge,Pascal Sienaert et al.
Annelies Dellink et al.
Background: Electroconvulsive therapy (ECT) is among the most effective treatments for severe depression, yet determining who will benefit remains challenging due to the lack of reliable predictors of treatment response. ...
Decreased Specific Pavlovian-to-Instrumental Transfer Effect in Internet Gaming Disorder Following Short-Term Abstinence from Gaming [0.03%]
网络游戏戒断期短期不玩游戏后的帕夫洛夫式转化为工具性转移效应的降低
Yanyin Zhou,Yelu Liu,Dantong Wu et al.
Yanyin Zhou et al.
Background and aims: Enhanced game-related specific Pavlovian-to-instrumental transfer (SPIT) has been observed in Internet Gaming Disorder (IGD). However, it remains unclear whether this effect is malleable. This study e...
Clinicians' Preferences and Attitudes Toward the Use of Lithium in the Treatment of Bipolar Disorders in Mexico [0.03%]
墨西哥临床医生在双相情感障碍治疗中使用锂的态度和倾向
Carlos Arnaud-Gil,Manuel Sánchez de Carmona,Bernardo Ng et al.
Carlos Arnaud-Gil et al.
Introduction Lithium remains a crucial treatment for bipolar disorder, with well-supported effectiveness in stabilizing mood and preventing suicide. A global decline in lithium prescriptions has been observed-often due to safety concerns, d...
Prevalence of psychotic symptoms and their clinical correlates in elderly major depressive disorder patients with subclinical hypothyroidism [0.03%]
亚临床甲状腺功能减退对老年抑郁症患者精神病性症状及其临床相关性的影响
Xiuwen Wang,Min Li,Xiao-Qian Wang et al.
Xiuwen Wang et al.
Background: In patients with major depressive disorder (MDD), thyroid dysfunction is highly associated with depression severity and psychotic symptoms such as delusions and hallucinations. However, the prevalence and clin...