A brief historic review of research on early life stress and inflammation across the lifespan [0.03%]
生命全程早年应激与炎症研究的简要历史回顾
Sonja Entringer,Christine Heim
Sonja Entringer
Background: Substantial evidence from epidemiological and clinical studies suggests that exposure to stress during sensitive developmental periods strongly and robustly increases the risk for psychiatric and physical diso...
Immunological Approaches in the Diagnosis and Treatment of Psychiatric Disorders: A Historical Overview [0.03%]
精神病免疫学诊断和治疗的历史概述
Norbert Müller
Norbert Müller
Background: For over 130 years, scientists have been suggesting that infection and inflammation may play a role in psychosis and other psychiatric disorders. First attempts to treat psychosis by immune-modulating therapie...
The saNeuroGut Initiative: Investigating the Gut Microbiome and Symptoms of Anxiety, Depression, and Posttraumatic Stress [0.03%]
脑肠计划：调查肠道微生物组和焦虑、抑郁以及创伤后应激障碍症状的关系
Michaela A O&#x;Hare,Patricia C Swart,Stefanie Malan-Müller et al.
Michaela A O&#x;Hare et al.
Introduction: Common mental disorders, such as anxiety disorders, depression, and posttraumatic stress disorder (PTSD), present a substantial health and economic burden. The gut microbiome has been associated with these p...
A Glucocorticoid-Mediated Immunoregulatory Circuit Integrated at Brain Levels: Our Early Studies and a Present View [0.03%]
大脑水平介导的糖皮质激素免疫调节回路：我们的早期研究和当前观点
Hugo Besedovsky,Adriana Del Rey
Hugo Besedovsky
Background: It was known since the 1940s that pharmacological administration of glucocorticoids can inhibit inflammatory and immune processes, and these hormones are still today among the most widely used therapeutic tool...
Looking Back to Move Forward: Research in Stress, Behavior, and Immune Function [0.03%]
以史为鉴可以知未来：应激、行为和免疫功能的研究进展
Alexander M Kuhn,Kelly E Bosis,Eric S Wohleb
Alexander M Kuhn
Background: From the original studies investigating the effects of adrenal gland secretion to modern high-throughput multidimensional analyses, stress research has been a topic of scientific interest spanning just over a ...
A History of Psycho-Neuro-Endocrine Immune Interactions in Rheumatic Diseases [0.03%]
风湿病心理神经内分泌免疫相互作用研究进展
Rainer H Straub,Maurizio Cutolo
Rainer H Straub
Background: All active scientists stand on the shoulders of giants and many other more anonymous scientists, and this is not different in our field of psycho-neuro-endocrine immunology in rheumatic diseases. Too often, th...
Qi Tian,Ziang Yan,Yujia Guo et al.
Qi Tian et al.
Background: Chemokine ligands and their corresponding receptors are essential for regulating inflammatory responses. Chemokine receptors can stimulate immune activation or inhibit/promote signaling pathways by binding to ...
Cytokines in Cerebrospinal Fluid and Chronic Pain in Humans: Past, Present, and Future [0.03%]
脑脊液细胞因子与人类慢性疼痛：过去、现在和未来
Alexander H C Rosenström,Jan-Pieter Konsman,Eva Kosek
Alexander H C Rosenström
Background: That neuroimmune interaction occurs in chronic pain conditions has been established for over a century, since the discovery of neurogenic inflammation in the periphery. However, the central aspects of neuroimm...