Heat stress-activated P2X7 receptor induces astrocyte activation and regulates glioma tumor microenvironment via calcium signaling pathway [0.03%]
热应激激活的P2X7受体通过钙信号通路诱导星形胶质细胞活化并调节胶质瘤肿瘤微环境
Qiang Wang,XiangRui Chen,JiuJiang Zhang et al.
Qiang Wang et al.
Background and aims: The effects of adjuvant hyperthermia on glioblastoma-associated astrocytes remain poorly characterized. This study aimed to investigate the role of the purinergic P2X7 receptor, an ATP-gated ion chann...
The mechanism of carboxypeptidase E regulating NLRP3 inflammasome signaling in the pathogenesis of depression-like behaviors in mice [0.03%]
羧肽酶E调控NLRP3炎性小体信号在抑郁样行为病程中的机制研究
Xili Yang,Zhimin Qi,Song Huang et al.
Xili Yang et al.
Objective: Depression is a common mental disease. Carboxypeptidase E (CPE) may be a therapeutic target for depression. This study aims to investigate whether CPE regulates NOD-like receptor protein 3 (NLRP3) inflammasome ...
Extracellular matrix mediated neuroendocrine control of the thymus [0.03%]
extracellular matrix介导的神经内分泌胸腺控制
Jordano Brito-Moreira,Edla Azevedo Herculano,Wilson Savino
Jordano Brito-Moreira
The thymus is the primary lymphoid organ responsible for the generation of a self-tolerant and immunocompetent T-cell repertoire. Its function is not autonomous but is finely tuned by a complex neuroendocrine network, integrating signals fr...
Inflammation-Induced Temperature Shifts and Mitochondrial Function: Rethinking Biomarker Interpretation in Depressive Disorders [0.03%]
炎症引起的体温变化和线粒体功能：重新思考抑郁症生物标志物的解释
Alexander Karabatsiakis,Rafael Pfeiffer,Annalena Steinlechner et al.
Alexander Karabatsiakis et al.
The Participation Of Prolactin In The Immunopathology Of Experimental Pulmonary Tuberculosis [0.03%]
催乳素参与实验性肺结核免疫病理过程的作用
Dulce Adriana Mata-Espinosa,Gabriel Quintero-Bustos,Daniel Enrique Castillo Baltazar et al.
Dulce Adriana Mata-Espinosa et al.
Introduction: Prolactin and its receptor are widely recognized for their roles in lactogenesis and galactopoiesis. However, they have also gained attention for their role in immune pathophysiology, acting as mediators of ...
Mycobacterium vaccae NCTC 11659 attenuates early life adversity (ELA)-induced hippocampal neuroinflammation in mice [0.03%]
牛分枝杆菌NCTC 11659减轻小鼠早期生活逆境引起的海马神经炎症
Tamara Schimmele,Nina M Castaneda,Giulia Mazzari et al.
Tamara Schimmele et al.
Early life adversity (ELA) is a potent risk factor for negative mental health outcomes, in part through its enduring effects on neuroimmune function. The hippocampus is particularly sensitive to stress across the lifespan, and neuroinflamma...
Depressive symptoms in obese individuals accompanied by greater basal inflammation but lower monocyte inflammatory responses to LPS: a quest to uncover immunologic links between depression and obesity [0.03%]
肥胖伴抑郁症状者的基础炎症反应增强但单核细胞活化后的炎性因子分泌减少：探索抑郁症和肥胖症的免疫学联系
Suzi Hong,Jordan Kohn,Stoyan Dimitrov et al.
Suzi Hong et al.
Introduction: Despite the high prevalence of co-occurring conditions between obesity and depression, the knowledge of the underlying mechanisms remains limited. Given the existing evidence of obesity being an inflammatory...
A Comprehensive Review of Worldwide Case Series of Neurocysticercosis and Mesial Temporal Lobe Epilepsy with Hippocampal Sclerosis [0.03%]
全球神经囊尾蚴病和海马硬化内侧颞叶癫痫病例系列的全面回顾性研究
Iris E Martínez-Juárez,Santiago Philibert-Rosas,Irving Fuentes-Calvo et al.
Iris E Martínez-Juárez et al.
Background: Neurocysticercosis (NCC) is a frequent cause of epilepsy in endemic regions. An association between NCC and hippocampal sclerosis (HS), a key pathological substrate of mesial temporal lobe epilepsy, has been i...
NLRP3 Inflammasome activation in oxidative stress: A key mechanism driving neuroinflammation [0.03%]
氧化应激介导的NLRP3炎性小体活化在神经炎症中的作用机制研究
Crisalde Ramirez-Celis,Ari Misael Martínez-Torres,Julio Morán
Crisalde Ramirez-Celis
In acquired and neurodegenerative brain diseases, inflammation-mediated neuronal death contributes to the deterioration of neurological deficits in patients. In the innate immune system, the NLRP3 inflammasome is a cytosolic complex that re...
Glucocorticoids and neutrophil biology: impact on the development of resistance to glucocorticoid therapy [0.03%]
糖皮质激素与中性粒细胞生物学：对糖皮质激素治疗抵抗发展的影响
Fabiana Santos Pacheco,Rayssa Garcia Rocha Mota,Yago Amigo Pinho Jannini de Sá et al.
Fabiana Santos Pacheco et al.
Neutrophils are the most abundant leukocytes in peripheral circulation and play a crucial role in combating infections and mediating inflammatory responses. Neutrophils are produced in bone marrow, have a short half-life in the blood, and a...