The novel SSTR3 full agonist ITF2984 shows antitumor properties against pancreatic neuroendocrine tumors (Pan-NETs) [0.03%]
新型SSTR3全激动剂ITF2984对胰腺神经内分泌肿瘤(Pan-NETs)的抗肿瘤作用
Margarita Bistika,Alessandro Marangelo,Francesco Ascione et al.
Margarita Bistika et al.
Background: Somatostatin analogs (SSAs) binding to and activating somatostatin receptors (SSTRs) have been extensively used for the treatment of neuroendocrine tumors (NETs). The currently approved synthetic SSAs have hig...
Plasma levels of organic acids associated with the gut microbiome display significant alterations in neuroendocrine tumor patients [0.03%]
与肠道微生物组相关的有机酸的血浆水平在神经内分泌肿瘤患者中显示出显著改变
Silje Udjus Johansen,Rasmus Goll,Anna Nordborg et al.
Silje Udjus Johansen et al.
Introduction: The gut microbiome, allegedly involved in both healthy homeostasis and development of disease, is found to be associated with several types of cancer. Short chain fatty acids (SCFAs), important metabolites d...
Immunohistochemical identification of sensory neuropeptides Calcitonin Gene-Related Peptide (CGRP), Substance P and Pituitary Adenylate Cyclase-Activating Polypeptide (PACAP) in Efferent Vestibular Nucleus neurons [0.03%]
血管活性肠肽、 calcitonin基因相关肽和物质p在传出前庭核神经元中的免疫组化研究
David Lorincz,Hannah Rose Drury,Rebecca Lim et al.
David Lorincz et al.
Introduction: The Efferent Vestibular System (EVS) originates in brainstem Efferent Vestibular Nuclei (EVN) and modifies afferent vestibular signals at their source, in peripheral vestibular organs. Recent evidence sugges...
Thyroid function and brain structure: insight from a Mendelian randomization study [0.03%]
甲状腺功能与脑结构：孟德尔随机化研究的新视角
Ping Li,Xiao Liu,Liming Wu et al.
Ping Li et al.
Background: Thyroid hormones play a critical role in brain development. However, the precise causal associations between thyroid function and structural changes in specific brain regions remain uncertain. ...
Hypothyroidism promotes microglia M1 polarization by inhibiting BDNF-promoted PI3K-Akt signaling pathway [0.03%]
甲状腺功能减退通过抑制BDNF促进的PI3K-Akt信号途径促进小胶质细胞M1极化
Yuan Zhan,Lang Lang,Fen Wang et al.
Yuan Zhan et al.
Hypothyroidism greatly affects the health-related quality of patients' life, and microglia in brain have essential functions on neurodegeneration, but the underlying link between hypothyroidism and microglia function is largely ambiguous. ...
Effect of thyroid status modulation on pituitary and peripheral hormone concentrations in healthy older subjects [0.03%]
甲状腺功能改变对健康老年人下丘脑激素浓度的影响
Evie van der Spoel,Saskia Cornet,Ana Zutinic et al.
Evie van der Spoel et al.
Introduction: Depending on age, sex, and familial longevity, alterations in thyroid status occur frequently, and often co-occur with differences in other hormonal axes. However, studies that explore the effects of thyroid...
Systemic Cancer Hallmarks as Novel Markers Associated with Progression-free Survival in Gastroenteropancreatic Neuroendocrine Tumor Patients Undergoing PRRT [0.03%]
系统性癌症标志物作为胃肠胰神经内分泌肿瘤患者进行肽受体放射性核素治疗(PRRT)时无进展生存率相关的新型标志物
Mahesh Kumar Padwal,Rahul Vithalrao Parghane,Avik Chakraborty et al.
Mahesh Kumar Padwal et al.
Introduction: Gastroenteropancreatic neuroendocrine tumors (GEP-NETs) are a heterogeneous group of tumors often detected at the metastatic stage. The aim of this study was to profile the peripheral blood transcriptome thr...
Elena Mormede,Pierre Mormede
Elena Mormede
Background: Many experimental data in several species clearly demonstrate the important genetic contribution to variations in HPA axis activity. The influence of corticosteroid hormones on adaptive processes and on produc...
Gray matter reserve modulates the association between glymphatic system function and cognition in patients with T2DM [0.03%]
糖代谢异常患者中胶质运系统功能和认知之间的关系受灰质储备调控
Wenqing Xia,Xiao Yin,Yujie Zhang et al.
Wenqing Xia et al.
Introduction: We aims to explore the relationship between the glymphatic function and cognitive function in patients with T2DM and whether this relationship is modulated by gray matter (GM) integrity. ...
Obesogens and Energy Homeostasis: Definition, Mechanisms of Action, Exposure and Adverse Effects on Human Health [0.03%]
外源性肥胖诱导物和能量稳态：定义、作用机制、暴露情况及对人体健康的不良影响
Bayram Yilmaz,Cihan Suleyman Erdogan,Suleyman Sandal et al.
Bayram Yilmaz et al.
Background: Obesity is a major risk factor for noncommunicable diseases and is associated with a reduced life expectancy of up to 20 years, as well as with other consequences such unemployment and increased economic burde...