John Karl Young
John Karl Young
Background: A number of factors contribute to the development of diabetes mellitus, but until recently, the role of hypothalamic dysfunction in the development of this disorder has not received sufficient attention. Hypot...
Direct Intra-Accumbens 17 Beta Estradiol Administration Increases Voluntary Wheel Running in Ovariectomized Rats [0.03%]
卵巢切除大鼠腹侧被盖区直接给予雌二醇能增加其自由跑步机运动量
Dusti Shay,Yonca Cam,Kayla Burkle et al.
Dusti Shay et al.
Metabolic dysfunction and the associated diseases (e.g. diabetes) are globally on the rise and a sedentary lifestyle directly contributes to this issue. In fact, post-menopausal women are at increased risk for obesity and metabolic disease ...
Soyasaponin Aa prevents obesity-related precocious puberty by inhibiting hypothalamic-pituitary-gonadal axis in female Sprague-Dawley rats [0.03%]
大豆皂苷Aa通过抑制下丘脑-垂体-性腺轴预防Sprague-Dawley大鼠肥胖相关性性早熟
Yunfei Jiang,Wen Xie,Dani Qin et al.
Yunfei Jiang et al.
Objective: Early-onset puberty is a major reason for pediatric endocrinology clinics, particularly among girls. Obesity is linked to disruptions in the hypothalamic-pituitary-gonadal (HPG) axis, thereby leading to early-o...
Differing ionotropic glutamate receptor gene expression in paraventricular hypothalamic nucleus subregions following angiotensin II hypertension in male mice and female mice with advanced ovarian failure [0.03%]
雄性小鼠和卵巢功能衰退的雌性小鼠在血管紧张素II高血压后下丘脑室旁核亚区的不同离子型谷氨酸受体基因表达
Garrett Sommer,Sumaya Omar Hussein,Teresa A Milner et al.
Garrett Sommer et al.
Introduction: The increased susceptibility to hypertension at menopause is characterized by alterations in brain circuits that regulate cardiovascular homeostasis, however, the mechanisms underlying this association are n...
Stress Hormone Dysregulation in Overweight Male Adults with Obstructive Sleep Apnea [0.03%]
肥胖OSA成人男性的应激激素失调
John Ming Ren Loh,Chung-Wei Lin,Hsin-Ching Lin et al.
John Ming Ren Loh et al.
Introduction: Obstructive sleep apnea (OSA) may influence the hypothalamic-pituitary-adrenal (HPA) axis and result in subsequent physiological dysregulation. Given the inconsistent findings of the current literature and t...
Radiotherapeutic Strategies and Advances in the Management of Pituitary Adenomas [0.03%]
垂体腺瘤的放射治疗策略及最新进展
Neil D Almeida,Jeff F Zhang,Harshini K Cheruvu et al.
Neil D Almeida et al.
Background: Pituitary adenomas are benign brain tumors that develop from hormone-producing cells in the anterior pituitary gland and account for 10-20% of all intracranial tumors. Although typically benign, pituitary aden...
A novel relationship between Corticotropin-releasing hormone level and high-altitude hypoxia in human and rat model [0.03%]
人和大鼠高原缺氧模型脑室下区CRH水平及其与学习记忆损伤的关系
Fan Ping Kong,Gang Xu,Ping Ping Wang et al.
Fan Ping Kong et al.
Background: Acute mountain sickness(AMS) strikes people who travel too quickly to high altitude, outstripping their ability to acclimatize. Individual susceptibility to AMS remains unpredictable. The aim of study was to i...
A Systematic Review of the Effects of N-Methyl-D-Aspartate Receptor Antagonists on Pancreatic Islets [0.03%]
天冬氨酸受体拮抗剂对胰岛影响的系统性研究
Sabrina Wong,Gia Han Le,John Uhlig et al.
Sabrina Wong et al.
Background N-methyl-D-aspartate receptors (NMDARs) are widely distributed in the brain and pancreas. Preliminary evidence indicates that aberrant NMDAR-mediated glutamatergic signaling may disrupt pancreatic islet function and glucose-insul...