Acute optogenetic activation of the subfornical organ produces sympathetically mediated increases in blood pressure [0.03%]
急性光遗传激活下丘福射体器官产生自主神经介导的血压升高反应
Monique L Van Acquoy,Teodora Nedelkoska,Simon McMullan et al.
Monique L Van Acquoy et al.
Introduction: The subfornical organ (SFO) is a vital blood pressure-controlling region that elicits blood pressure changes likely via an excitatory (or glutamatergic) projection to the paraventricular nucleus (PVN). Howev...
Upregulation of SSTR2 expression and radioligand binding of [18F]SiTATE in neuroendocrine tumour cells with combined inhibition of class I HDACs and LSD1 [0.03%]
组蛋白去乙酰酶和LSD1联合抑制诱导神经内分泌肿瘤细胞[18F]SiTATE结合及SSTR2表达上调
Christoph J Auernhammer,Kathrin Zitzmann,Simon Lindner et al.
Christoph J Auernhammer et al.
Introduction: Peptide receptor radionuclide therapy (PRRT) is a highly effective, targeted treatment option in advanced neuroendocrine tumours (NETs). However, NET patients expressing low levels of Somatostatin receptor t...
The effect of metformin on prolactin concentration in women with hyperprolactinemia and subclinical hyperthyroidism [0.03%]
二甲双胍对高泌乳素血症和亚临床甲状腺功能亢进女性泌乳素浓度的影响
Robert Krysiak,Karolina Kowalcze,Bogusław Okopień
Robert Krysiak
Introduction: Because prolactin excess and hyperthyroidism are often complicated by hyperglycemia and impaired insulin sensitivity, many patients with both these disorders are treated with metformin. This drug inhibits se...
Neurotrophic effects of GH and GnRH in a full sciatic nerve transection model in male rats [0.03%]
在完全坐骨神经切断模型雄性大鼠中GH和GnRH的神经营养效应
Jorge J A Baca-Alonso,Denisse Calderón-Vallejo,Irma Hernández-Jasso et al.
Jorge J A Baca-Alonso et al.
Peripheral nerve injuries, such as sciatic nerve transection (SNT), are associated with significant sensory and motor deficits. Growth hormone (GH) and gonadotropin-releasing hormone (GnRH) have been shown to exert neurotrophic effects that...
Clinical and Genetic Factors Associated with Neuroendocrine Neoplasms - a UK Biobank Study [0.03%]
与神经内分泌肿瘤相关的临床和遗传因素-英国生物样本库研究
Harry David Green,Marie Line El-Asmar,Brian Rous et al.
Harry David Green et al.
Background Incidence of neuroendocrine neoplasms (NEN) is rising globally, yet clinical and genetic factors remain poorly understood. Evidence for the role of obesity is conflicted and studies on prospectively collected data is sparse. We a...
A review for the clinician: Classifications, genetics and treatment for Neuroendocrine Neoplasms of the Thymus (Thymic carcinoid) [0.03%]
临床医生综述：胸腺神经内分泌肿瘤（类癌）的分类、遗传学和治疗进展
Matthias Lang,Chrysanthi Anamaterou,Isabelle Mohr et al.
Matthias Lang et al.
This review covers current classification systems and the knowledge of genetic disorders and medical therapies. Thymic carcinoids or neuroendocrine neoplasms (t-NEN) are a rare entity with dismal prognosis. About 25% of the tumors are relat...
Catherine Bouvier Ellis,Nicola Jervis
Catherine Bouvier Ellis
Background Neuroendocrine neoplasms (NENs) are consistently referred to as a 'relatively' rare heterogenous group of 'tumours' with variability in their disease course and outcomes [1-7]. However, there is a lack of consensus in a) the grou...
Doppler Assessment of the Uterine Arteries is a Valuable Adjunct Tool for the Evaluation of Efficacy of Gonadotropin-Releasing Hormone Agonist Therapy in Girls with Central Precocious Puberty [0.03%]
多普勒评估子宫动脉是评价中枢性性早熟女孩促性腺激素释放激素激动剂治疗效果的宝贵辅助工具
Amanda Veiga Cheuiche,Letícia Guimarães da Silveira,Iara Regina Siqueira Lucena et al.
Amanda Veiga Cheuiche et al.
Introduction: Pelvic ultrasound has been studied for the follow-up of girls with precocious puberty during gonadotropin-releasing hormone agonists (GnRHa) therapy. The addition of Doppler evaluation of uterine arteries ne...
Cocaine self-administration differentially modulates the content of cholesterol, progesterone and testosterone in the brain and plasma of male rats [0.03%]
可卡因自我给药对雄性大鼠脑和血浆中胆固醇、孕酮和睾丸激素含量有差异性的调节作用
William B Inabinett,Shiyu Wang,Paige M Estave et al.
William B Inabinett et al.
Introduction: Chronic cocaine exposure results in changes in circulating steroid hormones, which is known to be associated with cocaine-seeking and taking behavior. However, whether cocaine also alters the brain content o...
Involvement of the AVP/OT system and lateral septum in the modulation of anxiety/depression caused by 14-week and 20-week social isolation [0.03%]
AVP/OT系统和外侧隔核在14周和20周社交隔离引起焦虑/抑郁的调控中的作用
Jing Liu,Weizheng Zhang,Yuting Bai et al.
Jing Liu et al.
Introduction: Chronic social isolation (CSI) stress leads to numerous maladaptive changes in physiology and psychology, however, very little is known about the effects of longer time-scale CSI and there are divergent view...